(data stored in ACNUC8465 zone)

SWISSPROT: B6H1X6_PENRW

ID   B6H1X6_PENRW            Unreviewed;       275 AA.
AC   B6H1X6;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 50.
DE   SubName: Full=Pc13g03650 protein {ECO:0000313|EMBL:CAP91434.1};
GN   ORFNames=Pc13g03650 {ECO:0000313|EMBL:CAP91434.1}, PCH_Pc13g03650
GN   {ECO:0000313|EMBL:CAP91434.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91434.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91434.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC       {ECO:0000256|RuleBase:RU004474}.
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DR   EMBL; AM920428; CAP91434.1; -; Genomic_DNA.
DR   RefSeq; XP_002558802.1; XM_002558756.1.
DR   STRING; 500485.XP_002558802.1; -.
DR   EnsemblFungi; CAP91434; CAP91434; PCH_Pc13g03650.
DR   GeneID; 8313465; -.
DR   KEGG; pcs:Pc13g03650; -.
DR   eggNOG; KOG1324; Eukaryota.
DR   eggNOG; COG0262; LUCA.
DR   HOGENOM; HOG000214262; -.
DR   KO; K00287; -.
DR   OMA; YEFQMWV; -.
DR   OrthoDB; EOG092C4LJX; -.
DR   BioCyc; PCHR:PC13G03650-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0004146; F:dihydrofolate reductase activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR   GO; GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.
DR   CDD; cd00209; DHFR; 1.
DR   Gene3D; 3.40.430.10; -; 1.
DR   InterPro; IPR012259; DHFR.
DR   InterPro; IPR024072; DHFR-like_dom.
DR   InterPro; IPR017925; DHFR_CS.
DR   InterPro; IPR001796; DHFR_dom.
DR   Pfam; PF00186; DHFR_1; 1.
DR   PRINTS; PR00070; DHFR.
DR   SUPFAM; SSF53597; SSF53597; 2.
DR   PROSITE; PS00075; DHFR_1; 1.
DR   PROSITE; PS51330; DHFR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H1X6.
DR   SWISS-2DPAGE; B6H1X6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN       11    273       DHFR (dihydrofolate reductase).
FT                                {ECO:0000259|PROSITE:PS51330}.
SQ   SEQUENCE   275 AA;  29631 MW;  B37C798B66BABD3C CRC64;
     MPPHNPHHLP SLTLIVATTP IRTASTTTKE EITRLGIGLN GTLPWPRIKT DMSFFARVTS
     RPPTPGTTNA IIMGRKTYDS VPGSLRPLAK RINVVITRDT SGSVRESVTT ELGNMRRKIA
     AKAAQTQATN SEKGTFDPPK EAAPADPMTD AIVTPSLGAA LETLDSVYAA QGKLGKIFVI
     GGAEIYNATL NMGAEELRGR PVRVVMTNVV RKGAVGASAS FECDTFFPLD GLHEKNGWRA
     VSPREVSEWV GEEVDGEWKT DGDVEVQMVG YEKST
//

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