(data stored in ACNUC8465 zone)

SWISSPROT: B6H220_PENRW

ID   B6H220_PENRW            Unreviewed;       475 AA.
AC   B6H220;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 46.
DE   RecName: Full=Nickel/cobalt efflux system {ECO:0000256|RuleBase:RU362101};
GN   ORFNames=Pc13g03730 {ECO:0000313|EMBL:CAP91442.1}, PCH_Pc13g03730
GN   {ECO:0000313|EMBL:CAP91442.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91442.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91442.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- SIMILARITY: Belongs to the NiCoT transporter (TC 2.A.52) family.
CC       {ECO:0000256|RuleBase:RU362101}.
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DR   EMBL; AM920428; CAP91442.1; -; Genomic_DNA.
DR   RefSeq; XP_002558810.1; XM_002558764.1.
DR   STRING; 500485.XP_002558810.1; -.
DR   EnsemblFungi; CAP91442; CAP91442; PCH_Pc13g03730.
DR   GeneID; 8313473; -.
DR   KEGG; pcs:Pc13g03730; -.
DR   eggNOG; ENOG410IH47; Eukaryota.
DR   eggNOG; COG3376; LUCA.
DR   HOGENOM; HOG000236991; -.
DR   KO; K07241; -.
DR   OMA; WSILVFP; -.
DR   OrthoDB; EOG092C3VGN; -.
DR   BioCyc; PCHR:PC13G03730-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015099; F:nickel cation transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR004688; Ni/Co_transpt.
DR   InterPro; IPR011541; Ni/Co_transpt_high_affinity.
DR   PANTHER; PTHR31611; PTHR31611; 1.
DR   Pfam; PF03824; NicO; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H220.
DR   SWISS-2DPAGE; B6H220.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Membrane {ECO:0000256|RuleBase:RU362101};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724};
KW   Transmembrane {ECO:0000256|RuleBase:RU362101};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362101};
KW   Transport {ECO:0000256|RuleBase:RU362101}.
FT   TRANSMEM     45     71       Helical. {ECO:0000256|RuleBase:RU362101}.
FT   TRANSMEM    122    142       Helical. {ECO:0000256|RuleBase:RU362101}.
FT   TRANSMEM    154    177       Helical. {ECO:0000256|RuleBase:RU362101}.
FT   TRANSMEM    226    248       Helical. {ECO:0000256|RuleBase:RU362101}.
FT   TRANSMEM    254    273       Helical. {ECO:0000256|RuleBase:RU362101}.
FT   TRANSMEM    327    354       Helical. {ECO:0000256|RuleBase:RU362101}.
FT   TRANSMEM    374    397       Helical. {ECO:0000256|RuleBase:RU362101}.
SQ   SEQUENCE   475 AA;  51674 MW;  FA822FE66A52EBA0 CRC64;
     MSGFNELVDT DLRGLDSDRK WSLQPLLRSA ERSHSKMPGI RKIPLRAIGI IAFIALLNII
     VWVAAAIVLS YHHSLVSTAA LAYSLGLRHA FDADHISAID LMTRRLLATG QKPVTVGTFF
     SLGHSTIVII TSIVVAATAA AVSERFDSFS TVGGIIGTSV SAAFLILLGL MNAYILYKLV
     KQMEKVFNLP EGHEDEAWKI EGGGILFSVL KKMFKLIDRS WKMYPLGILF GLGFDTSSEI
     ALLGISSIEA AKGTSFWVIL ILPALFTAGM CLLDTIDGAL MFSLYIQPAA NFLPQKPTSD
     VSDTSSTATD PDELPQSQDN HRDPVAFLYY SIVLTTLTVI VAIVIGIIQL LTLILNVTDA
     KGKFWDGVQV AGDYYDAIGG GICGCFIVFG LLSVLVYKPW RRWMDQRHGK HVANDVERYT
     DDDISRGDAP GYGAIVTETS RTQHEGTATE VTGKGPASRV AVKETGESRL EDHIM
//

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