(data stored in ACNUC8465 zone)

SWISSPROT: B6H276_PENRW

ID   B6H276_PENRW            Unreviewed;      2273 AA.
AC   B6H276;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 60.
DE   SubName: Full=Pc13g03920 protein {ECO:0000313|EMBL:CAP91461.1};
GN   ORFNames=Pc13g03920 {ECO:0000313|EMBL:CAP91461.1}, PCH_Pc13g03920
GN   {ECO:0000313|EMBL:CAP91461.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91461.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91461.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- COFACTOR:
CC       Name=biotin; Xref=ChEBI:CHEBI:57586;
CC         Evidence={ECO:0000256|SAAS:SAAS00198459};
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DR   EMBL; AM920428; CAP91461.1; -; Genomic_DNA.
DR   RefSeq; XP_002558828.1; XM_002558782.1.
DR   ProteinModelPortal; B6H276; -.
DR   STRING; 500485.XP_002558828.1; -.
DR   EnsemblFungi; CAP91461; CAP91461; PCH_Pc13g03920.
DR   GeneID; 8304037; -.
DR   KEGG; pcs:Pc13g03920; -.
DR   eggNOG; KOG0368; Eukaryota.
DR   eggNOG; COG0439; LUCA.
DR   eggNOG; COG0511; LUCA.
DR   eggNOG; COG4799; LUCA.
DR   HOGENOM; HOG000214115; -.
DR   KO; K11262; -.
DR   OMA; FTPPCQR; -.
DR   OrthoDB; EOG092C00TE; -.
DR   BioCyc; PCHR:PC13G03920-MONOMER; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004075; F:biotin carboxylase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   InterPro; IPR034733; AcCoA_carboxyl.
DR   InterPro; IPR013537; AcCoA_COase_cen.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR005481; BC-like_N.
DR   InterPro; IPR001882; Biotin_BS.
DR   InterPro; IPR011764; Biotin_carboxylation_dom.
DR   InterPro; IPR005482; Biotin_COase_C.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR016185; PreATP-grasp_dom.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF08326; ACC_central; 1.
DR   Pfam; PF02785; Biotin_carb_C; 1.
DR   Pfam; PF00289; Biotin_carb_N; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   Pfam; PF02786; CPSase_L_D2; 1.
DR   SMART; SM00878; Biotin_carb_C; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   SUPFAM; SSF51246; SSF51246; 1.
DR   SUPFAM; SSF52096; SSF52096; 2.
DR   SUPFAM; SSF52440; SSF52440; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS50979; BC; 1.
DR   PROSITE; PS00188; BIOTIN; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
DR   PROSITE; PS00866; CPSASE_1; 1.
DR   PROSITE; PS00867; CPSASE_2; 1.
PE   4: Predicted;
DR   PRODOM; B6H276.
DR   SWISS-2DPAGE; B6H276.
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00449439};
KW   Biotin {ECO:0000256|SAAS:SAAS00064008};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Ligase {ECO:0000256|SAAS:SAAS00234187};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00409,
KW   ECO:0000256|SAAS:SAAS00449848};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN       46    554       Biotin carboxylation.
FT                                {ECO:0000259|PROSITE:PS50979}.
FT   DOMAIN      198    395       ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
FT   DOMAIN      681    755       Lipoyl-binding. {ECO:0000259|PROSITE:
FT                                PS50968}.
FT   DOMAIN     1506   1848       CoA carboxyltransferase N-terminal.
FT                                {ECO:0000259|PROSITE:PS50980}.
FT   DOMAIN     1852   2167       CoA carboxyltransferase C-terminal.
FT                                {ECO:0000259|PROSITE:PS50989}.
SQ   SEQUENCE   2273 AA;  253086 MW;  C988A129BF4F4D8D CRC64;
     MGSTMGNSSA VTKHDIPSHF IGGNALESAP PSAVKDFVAA HDGHSVITSV LIANNGIAAV
     KEIRSVRKWA YETFGNERAI QFTVMATPED LTANADYIRM ADQYVEVPGG TNNNNYANVE
     LIVDVAERMD VHAVWAGWGH ASENPRLPES LAASPKKIIF IGPPASAMRS LGDKISSTIV
     AQHAGVPCIP WSGTGVDAVK LDENGIVTVE DEVYNQGCTF SPEEGLAKAK EIGFPVMVKA
     SEGGGGKGIR KVENEEDFPA LYNAAANEIP GSPIFIMKLA GNARHLEVQL LADQYGNNIS
     LFGRDCSVQR RHQKIIEEAP VTIAKQPTFQ AMERAAVSLG KLVGYVSAGT VEYLYSHSDD
     KFYFLELNPR LQVEHPTTEM VSGVNLPAAQ LQIAMGIPLH RIRDIRLLYG VDPNTSADID
     FDFSKEESFQ TQRRPQPKGH TTACRITSED PGEGFKPSSG TMHELNFRSS SNVWGYFSVG
     TAGGIHSFSD SQFGHIFAYG ENRSASRKHM VVALKELSIR GDFRTTVEYL IKLLETPAFE
     DNTITTGWLD QLISNKLTAE RPDQIVAIIC GAVTKAHLAS EAGIEEYRNG LGKGQVPSKE
     ILKTVFPVDF IYEGERYKFT ATRASLDSYH LFINGSKCSV GVRALADGGL LVLLSGRSHN
     VYWKEEAAAT RLSVDGKTCL LEQENDPTQL RSPSPGKLVK FTVENGEHIR SGQSYAEVEV
     MKMYMPLIAK EDGIVQLIKQ PGATLEAGDI LGILALDDPS RVKHAQPFTG QLPELGSPTV
     LGNKPSQRFF LLHSILENIL RGFDNQVIMG TTLKDLVEVL RNPDLPYGEW NAQSSALHSR
     IPQKLDAQLQ NVVDRAKARK AEFPAKQLQK AIVRFIEEHI GPADAELLKT TLLPLVQVIN
     KYMDGLKSNE YNVFIGLLEQ YYDVEKLFST HNLRDEDVIL KLREENKDDI TGIVHTVLSH
     SRIGSKNNLV LAILDMYRPN QPHLENVGTY FKPILKKLTE LESRSSAKVT LKAREVLIQC
     AMPSLDERLS QMEHILRSSV VESRYGETGW EHREPSLDVL KEVVDSKYTV FDVLPRFFVH
     ADPWVTLASL EVYVRRAYRA YTLKSIDYNA STEQPFLSWD FTLGKLGQRE FGVLNSTQPS
     APGTPIAEVN PFKRINSIGD MSLFVSDAAS DPVRKGVIIP VQYLEDAEEI LCKALEVFPV
     GGSNAKCPSE QGLIATLEGK RRPAPKPVSD SELTGVCNIA IRDIEDMEDA DLVAQMKQLL
     ADNKDELLAR RIRRVTFICG KQGVYPGYFT FRGPNYEEDL SIRHSEPALA FQLELGRLSK
     FNIKPVFTEN RNIHVYEAIG KGPENDKAID KRYFVRAVVR PGRLRDDIPT AEYLISEADR
     LMNDILDALE IIGNNNSDLN HIFINFSPVF NLQPVDVEQA LAGFLDRFGR RLWRLRVTGA
     EIRILCTDPA TGMPYPLRVI ISNTYGFIIN VELYIERKSE KGEWIFQSIG GTAKLGSMHL
     RPVSTPYPTK EWLQPKRYKA HLMGTQYVYD FPELFRQAFQ NSWTKIAEKI PSLYEKRPPV
     GECIDYSELV LDDTDNLVEV SREPGTNTHG MVGWIITART PEYPRGRRFI IVANDITFQI
     GSFGPQEDRF FHKCTELARK LGIPRIYLSA NSGARIGVAD ELIPFFSVAW NNPEKPEAGF
     KYLYLTPEVK KRFDASKKKE VITELVNDDG EERHKITTVI GAKDGLGVEC LKGSGLIAGA
     TSKAYEDIFT ITLVTCRSVG IGAYLVRLGQ RAIQVEGQPI ILTGAPAINK LLGREVYTSN
     LQLGGTQIMY KNGVSHMTAN DDFAGVEKIV EWMSFVPDKK NAPIPIRPWS DTWDRDVAYF
     PPPKQTYDVR WLIGGKEDVD GFLPGLFDKG SFEEALGGWA RTVVVGRARL GGIPMGVIAV
     ETRSVENVTP ADPANPDSME MIATEAGGVW YPNSAYKTAQ ALRDFNNGEQ LPVMILANWR
     GFSGGQRDMY NEVLKYGSYI VDALVKYEQP IFVYIPPHGE LRGGSWVVVD PTINPDQMEM
     YADEDSRGGV LEPEGMVNIK YRREKQLDTM ARLDATYGEL RRSLADTSLT NEQLSEVKAK
     MAAREEQLLP VYMQIALQFA DLHDRAGRMQ AKDTIRKPLQ WVNSRRFFYW RLRRRLSEET
     IVKRMVAASA PAASGVGATG ESLRTAHLRT LHAWTGLLDE ELEHDDHKVA TWYEENKKVV
     QSKVESLRTD GVASEVAQLL IGNKEGGLRG VQQVLSMLPV EERENVLKYL GSA
//

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