(data stored in ACNUC8465 zone)

SWISSPROT: B6H2A4_PENRW

ID   B6H2A4_PENRW            Unreviewed;       276 AA.
AC   B6H2A4;
DT   16-DEC-2008, integrated into UniProtKB/TrEMBL.
DT   16-DEC-2008, sequence version 1.
DT   07-JUN-2017, entry version 52.
DE   RecName: Full=Orotidine 5'-phosphate decarboxylase {ECO:0000256|RuleBase:RU000512};
DE            EC=4.1.1.23 {ECO:0000256|RuleBase:RU000512};
GN   Name=pyrG {ECO:0000313|EMBL:CAP91511.1};
GN   ORFNames=PCH_Pc13g04420 {ECO:0000313|EMBL:CAP91511.1};
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 /
OS   Wisconsin 54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485 {ECO:0000313|EMBL:CAP91511.1, ECO:0000313|Proteomes:UP000000724};
RN   [1] {ECO:0000313|EMBL:CAP91511.1, ECO:0000313|Proteomes:UP000000724}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255
RC   {ECO:0000313|Proteomes:UP000000724};
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A.,
RA   van der Klei I.J., van Peij N.N.M.E., Veenhuis M., von Doehren H.,
RA   Wagner C., Wortman J.R., Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- CATALYTIC ACTIVITY: Orotidine 5'-phosphate = UMP + CO(2).
CC       {ECO:0000256|RuleBase:RU000512}.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from orotate: step 2/2.
CC       {ECO:0000256|RuleBase:RU000512}.
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000512}.
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DR   EMBL; AM920428; CAP91511.1; -; Genomic_DNA.
DR   RefSeq; XP_002558877.1; XM_002558831.1.
DR   ProteinModelPortal; B6H2A4; -.
DR   STRING; 500485.XP_002558877.1; -.
DR   EnsemblFungi; CAP91511; CAP91511; PCH_Pc13g04420.
DR   GeneID; 8312314; -.
DR   KEGG; pcs:Pc13g04420; -.
DR   eggNOG; KOG1377; Eukaryota.
DR   eggNOG; COG0284; LUCA.
DR   HOGENOM; HOG000213905; -.
DR   KO; K01591; -.
DR   OMA; MGQQYRT; -.
DR   OrthoDB; EOG092C3SZ1; -.
DR   UniPathway; UPA00070; UER00120.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR014732; OMPdecase.
DR   InterPro; IPR018089; OMPdecase_AS.
DR   InterPro; IPR001754; OMPdeCOase_dom.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   Pfam; PF00215; OMPdecase; 1.
DR   SMART; SM00934; OMPdecase; 1.
DR   SUPFAM; SSF51366; SSF51366; 1.
DR   TIGRFAMs; TIGR01740; pyrF; 1.
DR   PROSITE; PS00156; OMPDECASE; 1.
PE   3: Inferred from homology;
DR   PRODOM; B6H2A4.
DR   SWISS-2DPAGE; B6H2A4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000724};
KW   Decarboxylase {ECO:0000256|RuleBase:RU000512};
KW   Lyase {ECO:0000256|RuleBase:RU000512};
KW   Pyrimidine biosynthesis {ECO:0000256|RuleBase:RU000512};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000724}.
FT   DOMAIN       34    261       OMPdecase. {ECO:0000259|SMART:SM00934}.
SQ   SEQUENCE   276 AA;  29898 MW;  9E9937F97AB29C3F CRC64;
     MSSKSQLTYS ARAQSHPNPL ARKLFQVAEE KKSNVTVSAD VTTTKELLDL ADRLGPYIAV
     IKTHIDILSD FSQETIDGLN ALAQKHNFLI FEDRKFIDIG NTVQKQYHNG TLRISEWAHI
     INCSILPGEG IVEALAQTAQ ATDFPYGSER GLLILAEMTS KGSLATGAYT SASVDIARKY
     PSFVLGFVST RSLGEVESTE APAQGEDFVV FTTGVNLSSK GDKLGQQYQT PQSAVGRGAD
     FIISGRGIYA AADPVEAAKQ YQQQGWEAYL ARVGAQ
//

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