(data stored in SCRATCH zone)

SWISSPROT: C5DCA3_LACTC

ID   C5DCA3_LACTC            Unreviewed;       110 AA.
AC   C5DCA3;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   16-JAN-2019, entry version 45.
DE   RecName: Full=U6 snRNA-associated Sm-like protein LSm8 {ECO:0000256|RuleBase:RU365048};
GN   Name=LSM8 {ECO:0000256|RuleBase:RU365048};
GN   OrderedLocusNames=KLTH0B01408g {ECO:0000313|EMBL:CAR21414.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21414.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21414.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Plays role in pre-mRNA splicing as component of the
CC       U4/U6-U5 tri-snRNP complex that is involved in spliceosome
CC       assembly, and as component of the precatalytic spliceosome
CC       (spliceosome B complex). The heptameric LSM2-8 complex binds
CC       specifically to the 3'-terminal U-tract of U6 snRNA.
CC       {ECO:0000256|RuleBase:RU365048}.
CC   -!- SUBUNIT: LSm subunits form a heteromer with a doughnut shape.
CC       {ECO:0000256|RuleBase:RU365048}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365048}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC       {ECO:0000256|RuleBase:RU365048}.
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DR   EMBL; CU928166; CAR21414.1; -; Genomic_DNA.
DR   RefSeq; XP_002551852.1; XM_002551806.1.
DR   STRING; 381046.XP_002551852.1; -.
DR   EnsemblFungi; CAR21414; CAR21414; KLTH0B01408g.
DR   GeneID; 8290679; -.
DR   KEGG; lth:KLTH0B01408g; -.
DR   HOGENOM; HOG000000816; -.
DR   InParanoid; C5DCA3; -.
DR   KO; K12627; -.
DR   OMA; DEYLIWE; -.
DR   OrthoDB; 1545004at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005688; C:U6 snRNP; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR   CDD; cd01727; LSm8; 1.
DR   InterPro; IPR034103; Lsm8.
DR   InterPro; IPR001163; LSM_dom_euk/arc.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCA3.
DR   SWISS-2DPAGE; C5DCA3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   mRNA processing {ECO:0000256|RuleBase:RU365048};
KW   mRNA splicing {ECO:0000256|RuleBase:RU365048};
KW   Nucleus {ECO:0000256|RuleBase:RU365048};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Ribonucleoprotein {ECO:0000256|RuleBase:RU365048,
KW   ECO:0000256|SAAS:SAAS00679672};
KW   RNA-binding {ECO:0000256|RuleBase:RU365048};
KW   Spliceosome {ECO:0000256|RuleBase:RU365048}.
FT   DOMAIN        3     66       Sm. {ECO:0000259|SMART:SM00651}.
SQ   SEQUENCE   110 AA;  12110 MW;  4F2D6629A9697660 CRC64;
     MSPLLKDFLN KRIVVVTTDG QCVKAMLEGF DKSTNLLLSD VRDRVSGDVV ASSYLVRGNQ
     VVCCGLLEEE SSPQPDFGAE SVSAQLKDTK NIVPDEHLIW QRVWGMKAGK
//

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