(data stored in ACNUC8465 zone)

SWISSPROT: C5DCA6_LACTC

ID   C5DCA6_LACTC            Unreviewed;       945 AA.
AC   C5DCA6;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   10-APR-2019, entry version 53.
DE   SubName: Full=KLTH0B01496p {ECO:0000313|EMBL:CAR21417.1};
GN   OrderedLocusNames=KLTH0B01496g {ECO:0000313|EMBL:CAR21417.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21417.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21417.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
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DR   EMBL; CU928166; CAR21417.1; -; Genomic_DNA.
DR   RefSeq; XP_002551855.1; XM_002551809.1.
DR   STRING; 381046.XP_002551855.1; -.
DR   EnsemblFungi; CAR21417; CAR21417; KLTH0B01496g.
DR   GeneID; 8290683; -.
DR   KEGG; lth:KLTH0B01496g; -.
DR   HOGENOM; HOG000040280; -.
DR   InParanoid; C5DCA6; -.
DR   KO; K00288; -.
DR   OMA; GFHAYNI; -.
DR   OrthoDB; 690393at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:InterPro.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   CDD; cd00477; FTHFS; 1.
DR   CDD; cd01080; NAD_bind_m-THF_DH_Cyclohyd; 1.
DR   HAMAP; MF_01543; FTHFS; 1.
DR   HAMAP; MF_01576; THF_DHG_CYH; 1.
DR   InterPro; IPR000559; Formate_THF_ligase.
DR   InterPro; IPR020628; Formate_THF_ligase_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   Pfam; PF01268; FTHFS; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00721; FTHFS_1; 1.
DR   PROSITE; PS00722; FTHFS_2; 1.
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCA6.
DR   SWISS-2DPAGE; C5DCA6.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   DOMAIN        5    122       THF_DHG_CYH. {ECO:0000259|Pfam:PF00763}.
FT   DOMAIN      127    293       THF_DHG_CYH_C. {ECO:0000259|Pfam:
FT                                PF02882}.
SQ   SEQUENCE   945 AA;  101590 MW;  D0D4A72DDFC8AD21 CRC64;
     MVASLIDGKA IAKTIREEIS QEIKTMSSGA SGFRPTLAIF QVGNRPDSAT YVRMKCKAAE
     DAGIEVRFVH LDEDVAEHTL LTQVQEMNED SSVDGILVQL PLPGHIDEDK ITSAVAARKD
     VDGFGAFNIG ELNKKNGKPF FHPCTPEGII ELLVRNDVPI AGARALVIGR SDIVGSPVAE
     LLKARDATVT VVHSKSKDIP DYVSKADIVV VAIGRPEFVK GAWFEGNSNC VVIDVGTNYV
     DDASKKSGYR CVGDVEFEAA RQHVRLITPV PGGVGPMTVA MLMSNVFKAA KRSLEGEGKP
     AFEPLPLNLA NPVPSDFEIS RAQKPKEITQ VAAEAGILPS ELEPYGSTKA KVKLDILDRL
     GSRQNGKYVL VAGITPTPLG EGKSTTTVGL AQALGAHLKK TVFANVRQPS MGPTFGIKGG
     AAGGGYSQVI PMDEFNLHVT GDIHAISMAN NLLAAAIDTR MFHEQTQKDA ALYKRLVPSK
     RGVRKFTPTM LRRLEKLGIN KEDPDSLTPE EITQFARLDI DPETITWKRV VDCNDRFLRG
     ITIGEAPTER GFKRETGFDI SVASECMAIL ALANSLSDMR ERLGKIVIGA SKSGVPVTCE
     DIGCAGAMTA LLKDAVKPNI MQTLEGTPVF VHAGPFANIS IGANSAISDK IALKLAGVDP
     TASEEVKKES QGYVVTEAGF DFTMGGERFL NIKCRSSGLV PDVVVIVATI RALKVHGGGP
     EVKADAPLPT EYLNENVDLL RKGCANLAKH ITNVKAYNLP VVIAINKMSS DTEREHEVVR
     EEALKAGADD ALVSNHWEEG GKGAVDLAEG VIKACEQPNN KFKFLYETEG SSVEEKINTI
     AKEMYGAGSV EFLPEAQKKI DLYTKQGFSN LPICIAKTQY SLSHDANLKG VPTGFKFPIR
     DVRASVGAGY LYALAAEIQT IPGLPTHCGF MNIEVNEKGE IEGMF
//

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