(data stored in ACNUC8465 zone)

SWISSPROT: C5DCG7_LACTC

ID   C5DCG7_LACTC            Unreviewed;       658 AA.
AC   C5DCG7;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   11-DEC-2019, entry version 47.
DE   RecName: Full=Nucleolar complex-associated protein 3 {ECO:0000256|PIRNR:PIRNR028977};
GN   OrderedLocusNames=KLTH0B02926g {ECO:0000313|EMBL:CAR21478.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21478.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21478.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Required for synthesis of 60S ribosomal subunits and the
CC       transport of pre-ribosomes from the nucleoplasm to the cytoplasm.
CC       {ECO:0000256|PIRNR:PIRNR028977}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|PIRNR:PIRNR028977}.
CC   -!- SIMILARITY: Belongs to the CBF/MAK21 family.
CC       {ECO:0000256|PIRNR:PIRNR028977}.
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DR   EMBL; CU928166; CAR21478.1; -; Genomic_DNA.
DR   RefSeq; XP_002551916.1; XM_002551870.1.
DR   STRING; 381046.XP_002551916.1; -.
DR   EnsemblFungi; CAR21478; CAR21478; KLTH0B02926g.
DR   GeneID; 8290748; -.
DR   KEGG; lth:KLTH0B02926g; -.
DR   HOGENOM; HOG000168453; -.
DR   InParanoid; C5DCG7; -.
DR   KO; K14834; -.
DR   OMA; LWNTEER; -.
DR   OrthoDB; 341721at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR005612; CCAAT-binding_factor.
DR   InterPro; IPR011501; Noc3_N.
DR   InterPro; IPR016903; Nucleolar_cplx-assoc_3.
DR   PANTHER; PTHR14428; PTHR14428; 1.
DR   Pfam; PF03914; CBF; 1.
DR   Pfam; PF07540; NOC3p; 1.
DR   PIRSF; PIRSF028977; Nucleolar_complex_p3; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DCG7.
DR   SWISS-2DPAGE; C5DCG7.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Ribosome biogenesis {ECO:0000256|PIRNR:PIRNR028977}.
FT   DOMAIN          133..223
FT                   /note="NOC3p"
FT                   /evidence="ECO:0000259|Pfam:PF07540"
FT   DOMAIN          468..642
FT                   /note="CBF"
FT                   /evidence="ECO:0000259|Pfam:PF03914"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..127
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          130..165
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          361..402
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..66
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..103
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..119
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   658 AA;  74222 MW;  7E876815FECDADD1 CRC64;
     MGSKKRSQRV AEDKASKRRK EQDSLLEGGI FTREDVQEIE DSIPAKKSWD DEEQDYERKP
     RKLAGYPEDN IEQLPIKIGA KVERRIVRAP KVEPESNNDD SEDVDLMKND DEEQSTEADD
     SAVADSPEAV LQLKEQIAEL VENIMEDAEE NVGSLTRLRK MAQSKNSNTC KFSLLALIPV
     FKSVIPSYKI RPLSDAEKKE KVSKEVAKLR NFEEHLVRNY KEYIDLLSKL AKTPNSADQK
     QVAMGNLAAN ALVELLPSAS NFNFSTEVFT AIIRRICKPN PLADPVYQKM VKALETLLNE
     DDDGRNSLEI VRILAKTIKS RSYMIDESVL NILLSLDVLQ DFDPNTKDED FTKVKVKKKD
     RAHLSKKQRK VRKEMKKVEE EMQKAEQTVL AEEREKNQAE ILKFTLSLYL NILKSNVAKL
     IGSVLEGLSK FGHMANFDLL GDFLEVMREL IANSELDNLS PLEVRKVLLC IVTAFSLVSR
     HSQMKLSMDL TSFVDALYSV IPNLSVDAEI EYSHKTLRLA DPLGSDLVKP SVNVSTKAEL
     LLRALDHVFF RSRSGSKVRA AAFAKRLYVA MLATPEKTSI AILKFLEKLM DKYPEVGGLY
     STEDRIGNGN FKLQAETPAR SNAEAATIWE NILLLKHYSP AVIKGTKALL EKSRGSLK
//

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