(data stored in SCRATCH zone)

SWISSPROT: C5DCL9_LACTC

ID   C5DCL9_LACTC            Unreviewed;       816 AA.
AC   C5DCL9;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   RecName: Full=Ribosome biogenesis protein ERB1 {ECO:0000256|HAMAP-Rule:MF_03027};
DE   AltName: Full=Eukaryotic ribosome biogenesis protein 1 {ECO:0000256|HAMAP-Rule:MF_03027};
GN   Name=ERB1 {ECO:0000256|HAMAP-Rule:MF_03027};
GN   OrderedLocusNames=KLTH0B04136g {ECO:0000313|EMBL:CAR21530.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21530.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21530.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Component of the NOP7 complex, which is required for
CC       maturation of the 25S and 5.8S ribosomal RNAs and formation of the
CC       60S ribosome. {ECO:0000256|HAMAP-Rule:MF_03027}.
CC   -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC       YTM1. Within the NOP7 complex ERB1 appears to interact directly
CC       with NOP7 and YTM1. The NOP7 complex also associates with the 66S
CC       pre-ribosome. {ECO:0000256|HAMAP-Rule:MF_03027}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000256|HAMAP-
CC       Rule:MF_03027}. Nucleus, nucleoplasm {ECO:0000256|HAMAP-
CC       Rule:MF_03027, ECO:0000256|SAAS:SAAS00535448}.
CC   -!- SIMILARITY: Belongs to the WD repeat BOP1/ERB1 family.
CC       {ECO:0000256|HAMAP-Rule:MF_03027, ECO:0000256|SAAS:SAAS00535441}.
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DR   EMBL; CU928166; CAR21530.1; -; Genomic_DNA.
DR   RefSeq; XP_002551968.1; XM_002551922.1.
DR   STRING; 381046.XP_002551968.1; -.
DR   EnsemblFungi; CAR21530; CAR21530; KLTH0B04136g.
DR   GeneID; 8290803; -.
DR   KEGG; lth:KLTH0B04136g; -.
DR   HOGENOM; HOG000029368; -.
DR   InParanoid; C5DCL9; -.
DR   KO; K14824; -.
DR   OMA; SHGMVYN; -.
DR   OrthoDB; 759498at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03027; BOP1; 1.
DR   InterPro; IPR028598; BOP1/Erb1.
DR   InterPro; IPR012953; BOP1_N_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR17605; PTHR17605; 1.
DR   Pfam; PF08145; BOP1NT; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01035; BOP1NT; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
DR   PRODOM; C5DCL9.
DR   SWISS-2DPAGE; C5DCL9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Nucleus {ECO:0000256|HAMAP-Rule:MF_03027,
KW   ECO:0000256|SAAS:SAAS00416407};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Repeat {ECO:0000256|SAAS:SAAS00001985};
KW   Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03027,
KW   ECO:0000256|SAAS:SAAS00416412};
KW   rRNA processing {ECO:0000256|HAMAP-Rule:MF_03027,
KW   ECO:0000256|SAAS:SAAS00416397};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221,
KW   ECO:0000256|SAAS:SAAS00416391}.
FT   REPEAT      447    488       WD. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00221}.
FT   DOMAIN      447    488       WD_REPEATS_REGION. {ECO:0000259|PROSITE:
FT                                PS50294}.
FT   DOMAIN      671    816       WD_REPEATS_REGION. {ECO:0000259|PROSITE:
FT                                PS50294}.
FT   REPEAT      790    816       WD. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00221}.
SQ   SEQUENCE   816 AA;  92586 MW;  673DAED7D0247DF2 CRC64;
     MAKNQQAKRL STTRSNSKGE AEKKRELEEE SSDDELNVQG LIDDEADESD EDYSEVDSEA
     DETGQFQSAE EGEDGASEEE AGSDSDEEFN KLLAEEEPED GSEANESLEF SDASNSNSMV
     EKLSSIKLNM IPDQDEEVIR TKFSDGRPRT IKPEINPVYD SDDSDVEVQN TIGNIPLSAY
     DEMPHIGYSI NGKRIMRPAK GSALDQLLET IELPEGWTGL LDKDTGASLN LSQEELELIS
     KIQKNEKTDD SVDPYQPYVD WFTRHTETMP LTAVPEPKRR FVPSKNEAKR IMKIVRAIRE
     GRIIPPNKLK EMREEEESSH HYDLWGASDE SDDHVMNLRA PKLPPPTNEE SYNPPEEYLL
     SKEEKEEWEN QEPSERERNF VPQKFNALRK VPGYVESVRE RFERSLDLYL APRVRKNKLN
     IDPESLIPEL PSPKDLRPFP TRCSTIYRGH EGRIRTLSID PSGLWLATGS DDGSVRIWEI
     LTGREVYKVQ VVDPEAKSGD NVEAIEWNPD KTTGILAIAA GENIFLIVPP IFGFEVENTG
     RTKIEDGFGF DTYGNSKTSN LNVNSDDEND QPESTAVKSQ VAQWHKASQK QAEKDIAVVI
     TCRHTVKKLS WHRKGDYFVT VQPKSGHTSV LIHQLSKHLS QSPFKKSKGI VMDAKFHPFK
     PQLFVCSQRY VRIYDLSQQA LVKKLMPGAR WLSTIDIHPR GDNLLASSFD KRVLWHDLDL
     ASTPYKTLRY HEMAVRKVAF HKKLPLFCSA SDDSIIHVFH ATVYDDMLKN PLLVPLKKLE
     GHKVVNSLGV LDLVWHPREA WLFSAGADNT ARLWTS
//

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