(data stored in ACNUC8465 zone)

SWISSPROT: C5DD05_LACTC

ID   C5DD05_LACTC            Unreviewed;       576 AA.
AC   C5DD05;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   11-DEC-2019, entry version 61.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   OrderedLocusNames=KLTH0B07282g {ECO:0000313|EMBL:CAR21666.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21666.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21666.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|PIRNR:PIRNR005673}.
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DR   EMBL; CU928166; CAR21666.1; -; Genomic_DNA.
DR   RefSeq; XP_002552104.1; XM_002552058.1.
DR   STRING; 381046.XP_002552104.1; -.
DR   EnsemblFungi; CAR21666; CAR21666; KLTH0B07282g.
DR   GeneID; 8290944; -.
DR   KEGG; lth:KLTH0B07282g; -.
DR   HOGENOM; HOG000167616; -.
DR   InParanoid; C5DD05; -.
DR   KO; K15042; -.
DR   OMA; GINPYCS; -.
DR   OrthoDB; 1111872at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.20.5.690; -; 1.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importing_su_alpha.
DR   Pfam; PF00514; Arm; 8.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 2.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DD05.
DR   SWISS-2DPAGE; C5DD05.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Protein transport {ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036};
KW   Transport {ECO:0000256|PIRNR:PIRNR005673, ECO:0000256|PROSITE-
KW   ProRule:PRU00561}.
FT   DOMAIN          35..99
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          164..207
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          207..249
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          63..83
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          116..136
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..50
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   576 AA;  63818 MW;  DF57975F67EB0667 CRC64;
     MMEPNPSGTV RLQQLSASYK RTRSLSETLR PATQAMDSDS SSTNKFVPEY RRTNFKNKGR
     FSADELRRRR DTQQVELRKA KRDEALAKRR NFAAPPDGAD SEDEDEAAST ADQQFYQQLQ
     QELPQMIQQI NSTDLQEQLN ATVKFRQILS REHRPPIDTV IQSGVVPNLV NFMNENQPEM
     LQLEAAWALT NIASGSSDQT KVVVEAGAVP LFIQLLYSGS IEVKEQAIWA LGNVAGDSTG
     YRDYVLSCGA MQPILALFDL SKTSLIRTAT WTLSNLCRGK KPQPDWGVVS QSLPTLAKLI
     YSMDTETLVD ACWAISYLSD GPANNIQAVI DARIPKRLVE LLNHQSTLVQ TPALRAVGNI
     VTGNDLQTQV VINCGVLGAL RNLLSSTKES IRKEACWTIS NITAGNTDQI QAAIDANLIP
     ALVKLLETAD YKTKKEACWA ISNASSGGLQ KPEIIRYLVS QGSIKPLCDL LEIADNRIIE
     VTLDALENIL KMGEADKEAR GLHINENADY IERAGGVDKI FNCQQNENEK IYEKAFNIIE
     QYFGEDEDAL DESMAPQTAG NTFGFGSNVN QQFNFN
//

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