(data stored in ACNUC8465 zone)

SWISSPROT: C5DDA9_LACTC

ID   C5DDA9_LACTC            Unreviewed;       817 AA.
AC   C5DDA9;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit C {ECO:0000256|HAMAP-Rule:MF_03002};
DE            Short=eIF3c {ECO:0000256|HAMAP-Rule:MF_03002};
DE   AltName: Full=Eukaryotic translation initiation factor 3 93 kDa subunit homolog {ECO:0000256|HAMAP-Rule:MF_03002};
DE            Short=eIF3 p93 {ECO:0000256|HAMAP-Rule:MF_03002};
DE   AltName: Full=Translation initiation factor eIF3, p93 subunit homolog {ECO:0000256|HAMAP-Rule:MF_03002};
GN   Name=NIP1 {ECO:0000256|HAMAP-Rule:MF_03002};
GN   OrderedLocusNames=KLTH0B09680g {ECO:0000313|EMBL:CAR21770.1};
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295 {ECO:0000313|EMBL:CAR21770.1, ECO:0000313|Proteomes:UP000002036};
RN   [1] {ECO:0000313|EMBL:CAR21770.1, ECO:0000313|Proteomes:UP000002036}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284
RC   {ECO:0000313|Proteomes:UP000002036};
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P.,
RA   Jubin C., Poulain J., Barbe V., Segurens B., Artiguenave F.,
RA   Anthouard V., Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R.,
RA   Durrens P., Jean G., Marck C., Martin T., Nikolski M., Rolland T.,
RA   Seret M.-L., Casaregola S., Despons L., Fairhead C., Fischer G.,
RA   Lafontaine I., Leh V., Lemaire M., de Montigny J., Neuveglise C.,
RA   Thierry A., Blanc-Lenfle I., Bleykasten C., Diffels J., Fritsch E.,
RA   Frangeul L., Goeffon A., Jauniaux N., Kachouri-Lafond R., Payen C.,
RA   Potier S., Pribylova L., Ozanne C., Richard G.-F., Sacerdot C.,
RA   Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation
CC       factor 3 (eIF-3) complex, which is involved in protein synthesis
CC       of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi
CC       to the 40S ribosome. The eIF-3 complex specifically targets and
CC       initiates translation of a subset of mRNAs involved in cell
CC       proliferation. {ECO:0000256|HAMAP-Rule:MF_03002}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor
CC       3 (eIF-3) complex. {ECO:0000256|HAMAP-Rule:MF_03002,
CC       ECO:0000256|SAAS:SAAS00891357}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03002,
CC       ECO:0000256|SAAS:SAAS01184761}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit C family.
CC       {ECO:0000256|HAMAP-Rule:MF_03002, ECO:0000256|SAAS:SAAS01070822}.
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DR   EMBL; CU928166; CAR21770.1; -; Genomic_DNA.
DR   RefSeq; XP_002552208.1; XM_002552162.1.
DR   SMR; C5DDA9; -.
DR   STRING; 381046.XP_002552208.1; -.
DR   EnsemblFungi; CAR21770; CAR21770; KLTH0B09680g.
DR   GeneID; 8291051; -.
DR   KEGG; lth:KLTH0B09680g; -.
DR   HOGENOM; HOG000029414; -.
DR   InParanoid; C5DDA9; -.
DR   KO; K03252; -.
DR   OMA; VVMHRSE; -.
DR   OrthoDB; 273138at2759; -.
DR   Proteomes; UP000002036; Chromosome B.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03002; eIF3c; 1.
DR   InterPro; IPR027516; EIF3C.
DR   InterPro; IPR008905; EIF3C_N_dom.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR13937; PTHR13937; 1.
DR   Pfam; PF05470; eIF-3c_N; 2.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
DR   PRODOM; C5DDA9.
DR   SWISS-2DPAGE; C5DDA9.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002036};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03002,
KW   ECO:0000256|SAAS:SAAS01184774};
KW   Initiation factor {ECO:0000256|HAMAP-Rule:MF_03002,
KW   ECO:0000256|SAAS:SAAS01070816};
KW   Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_03002,
KW   ECO:0000256|SAAS:SAAS01070819};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002036}.
FT   DOMAIN      607    782       PCI. {ECO:0000259|PROSITE:PS50250}.
SQ   SEQUENCE   817 AA;  92549 MW;  622754637B84F56B CRC64;
     MSRFFANSYD YESGSSSSEE DLLSTSEEEL MSSSSSEEEQ ANDSFFDESE SESDVDSDGS
     GDRPYGPDWF KKPEFRKGGS TGANKFLKNA DYSNSEDSDD EGRKVVKSAK DKLLDEMRGV
     YDKIEDAEMT QDWITILAEL DNMTRLSTRA QQQNYGVPNI FVKVLAQVED AVAATSLQDI
     NNKAVARAYN TTKQRVRKVA RDYEQALSSF RENPEAHADD EAVQDNNSVS TFALAGKKTA
     DLSSMATASS ESDFFTALRI VIDSRGKKGT DFQAQIKTLE ELLDIAKSPY ETILAYLNLI
     PIRFDSSATL SYQPIDQWKA SQQDIAKLFD TLEDSIDAYH VSELAPHNDF IEEEPQPNEQ
     GIKQVLGSVY SFVERLDEEF NKSLLNTDPH SSDFLDRLKD EQGVYNLILR SQLYLEATSS
     DSELERRLAR VLTRRFDHIY FKSVKLVEVS ESKAWKSLRE GAKSKVTPLD GEVDESYTFG
     LIDTLHKMLS TQKDGAQRRR AGLYQIYFYA LNNQFEKAKH MLLSSHIQSS INNADAPLQI
     LFNRTVVQLG LAAFKLCLID DCHQILNEVS TSTHLRDILG QQSLQRVAAN NATNPGGASN
     EQLCLPFHQH INLDLIDVVF MTCSLLIEVP HMAAFFSGIK VKRIPYSQKS IRRALEHYDK
     SSFQGPPETL RDHVLYAAKS MQRGDWDKSV EYLKKVPTWS LLPNTAEVLT NLAHRVQVEA
     LRTYIFTYKR FYSKLSLLKL SQLFGLSQET VVEVVSAIIS QYDIKGRLDE ESKFLVFEKG
     YEITKLEEVA VKLAKETKYV SERLNEKKYV GSSRKQE
//

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