(data stored in ACNUC7421 zone)

SWISSPROT: RIHC_ECO27

ID   RIHC_ECO27              Reviewed;         304 AA.
AC   B7UI75;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 54.
DE   RecName: Full=Non-specific ribonucleoside hydrolase RihC {ECO:0000255|HAMAP-Rule:MF_01432};
DE            EC=3.2.-.- {ECO:0000255|HAMAP-Rule:MF_01432};
DE   AltName: Full=Purine/pyrimidine ribonucleoside hydrolase {ECO:0000255|HAMAP-Rule:MF_01432};
GN   Name=rihC {ECO:0000255|HAMAP-Rule:MF_01432};
GN   OrderedLocusNames=E2348C_0030;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Hydrolyzes both purine and pyrimidine ribonucleosides
CC       with a broad-substrate specificity. {ECO:0000255|HAMAP-
CC       Rule:MF_01432}.
CC   -!- SIMILARITY: Belongs to the IUNH family. RihC subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01432}.
DR   EMBL; FM180568; CAS07578.1; -; Genomic_DNA.
DR   RefSeq; WP_001239170.1; NC_011601.1.
DR   SMR; B7UI75; -.
DR   EnsemblBacteria; CAS07578; CAS07578; E2348C_0030.
DR   KEGG; ecg:E2348C_0030; -.
DR   KO; K12700; -.
DR   OMA; TPVAEWN; -.
DR   BioCyc; ECOL574521:E2348C_RS00150-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.245.10; -; 1.
DR   HAMAP; MF_01432; Nucleosid_hydro_RihC; 1.
DR   InterPro; IPR015910; I/U_nuclsd_hydro_CS.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR023186; IUNH.
DR   InterPro; IPR022976; Nucleosid_hydro_RihC_nonspecif.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   PANTHER; PTHR12304; PTHR12304; 1.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
DR   PROSITE; PS01247; IUNH; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UI75.
DR   SWISS-2DPAGE; B7UI75.
KW   Complete proteome; Glycosidase; Hydrolase.
FT   CHAIN         1    304       Non-specific ribonucleoside hydrolase
FT                                RihC.
FT                                /FTId=PRO_1000184896.
FT   ACT_SITE    233    233       {ECO:0000255|HAMAP-Rule:MF_01432}.
SQ   SEQUENCE   304 AA;  32657 MW;  7017C743765F3FD8 CRC64;
     MRLPIFLDTD PGIDDAVAIA AAIFTPELDL QLMTTVAGNV SVEKTTRNAL QLLHFWNVDI
     PLAQGAAVPL VRAPRDAASV HGESGMAGYD FVEHNRKPLG IPAFLAIRDA LMRAPEPVTL
     VAIGPLTNIA LLLSQCPECK PYIRRLVIMG GSAGRGNCTP NAEFNIAADP EAASCVFRSG
     IEIVMCGLDV TNQAILTPDY LATLPELNRT GKMLHALFSH YRSGSMQSGL RMHDLCAIAW
     LVRPELFTLK PCFVAVETQG EFTSGTTVVD IDGCLGKPAN VKVALDLNVK GFQQWVAEVL
     ALVP
//

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