(data stored in ACNUC7421 zone)

SWISSPROT: CAIT_ECO27

ID   CAIT_ECO27              Reviewed;         504 AA.
AC   B7UI86;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 57.
DE   RecName: Full=L-carnitine/gamma-butyrobetaine antiporter {ECO:0000255|HAMAP-Rule:MF_01049};
GN   Name=caiT {ECO:0000255|HAMAP-Rule:MF_01049};
GN   OrderedLocusNames=E2348C_0041;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Catalyzes the exchange of L-carnitine for gamma-
CC       butyrobetaine and related betaines. {ECO:0000255|HAMAP-
CC       Rule:MF_01049}.
CC   -!- PATHWAY: Amine and polyamine metabolism; carnitine metabolism.
CC       {ECO:0000255|HAMAP-Rule:MF_01049}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01049}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01049}.
CC   -!- SIMILARITY: Belongs to the BCCT transporter (TC 2.A.15) family.
CC       CaiT subfamily. {ECO:0000255|HAMAP-Rule:MF_01049}.
DR   EMBL; FM180568; CAS07589.1; -; Genomic_DNA.
DR   RefSeq; WP_000787104.1; NC_011601.1.
DR   SMR; B7UI86; -.
DR   EnsemblBacteria; CAS07589; CAS07589; E2348C_0041.
DR   KEGG; ecg:E2348C_0041; -.
DR   KO; K05245; -.
DR   OMA; AWAPFTG; -.
DR   BioCyc; ECOL574521:E2348C_RS00215-MONOMER; -.
DR   UniPathway; UPA00117; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044667; F:(R)-carnitine:4-(trimethylammonio)butanoate antiporter activity; IEA:InterPro.
DR   GO; GO:1900751; P:4-(trimethylammonio)butanoate transport; IEA:InterPro.
DR   GO; GO:0009437; P:carnitine metabolic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_01049; CaiT; 1.
DR   InterPro; IPR018093; BCCT_CS.
DR   InterPro; IPR000060; BCCT_transptr.
DR   InterPro; IPR023449; BCCT_transptr_CaiT.
DR   PANTHER; PTHR30047; PTHR30047; 1.
DR   Pfam; PF02028; BCCT; 1.
DR   TIGRFAMs; TIGR00842; bcct; 1.
DR   PROSITE; PS01303; BCCT; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UI86.
DR   SWISS-2DPAGE; B7UI86.
KW   Antiport; Cell inner membrane; Cell membrane; Complete proteome;
KW   Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN         1    504       L-carnitine/gamma-butyrobetaine
FT                                antiporter.
FT                                /FTId=PRO_1000149618.
FT   TRANSMEM     10     30       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM     51     71       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM     92    112       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    143    163       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    195    215       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    231    251       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    263    283       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    316    336       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    347    367       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    398    418       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    446    466       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
FT   TRANSMEM    475    495       Helical. {ECO:0000255|HAMAP-
FT                                Rule:MF_01049}.
SQ   SEQUENCE   504 AA;  56573 MW;  A8522606D303FD82 CRC64;
     MKNEKRKTGI EPKVFFPPLI IVGILCWLTV RDLDAANVVI NAVFSYVTNV WGWAFEWYMV
     VMLFGWFWLV FGPYAKKRLG NEPPEFSTAS WIFMMFASCT SAAVLFWGSI EIYYYISTPP
     FGLEPNSTGA KELGLAYSLF HWGPLPWATY SFLSVAFAYF FFVRKMEVIR PSSTLVPLVG
     EKHAKGLFGT IVDNFYLVAL IFAMGTSLGL ATPLVTECMQ WLFGIPHTLQ LDAIIITCWI
     ILNAICVACG LQKGVRIASD VRSYLSFLML GWVFIVSGAS FIMNYFTDSV GMLLMYLPRM
     LFYTDPIAKG GFPQGWTVFY WAWWVIYAIQ MSIFLARISR GRTVRELCFG MVLGLTASTW
     ILWTVLGSNT LLLIDKNIIN IPNLIEQYGV ARAIIETWAA LPLSTATMWG FFILCFIATV
     TLVNACSYTL AMSTCREVRD GEEPPLLVRI GWSVLVGIIG IVLLALGGLK PIQTAIIAGG
     CPLFFVNIMV TLSFIKDAKQ NWKD
//

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