(data stored in ACNUC7421 zone)

SWISSPROT: B7UIB8_ECO27

ID   B7UIB8_ECO27            Unreviewed;       536 AA.
AC   B7UIB8;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   05-DEC-2018, entry version 55.
DE   SubName: Full=Fused thiamin transporter subunits of ABC superfamily: membrane components {ECO:0000313|EMBL:CAS07621.1};
GN   Name=thiP {ECO:0000313|EMBL:CAS07621.1};
GN   OrderedLocusNames=E2348C_0073 {ECO:0000313|EMBL:CAS07621.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07621.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07621.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU363032}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363032}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport
CC       system permease family. {ECO:0000256|RuleBase:RU363032}.
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DR   EMBL; FM180568; CAS07621.1; -; Genomic_DNA.
DR   RefSeq; WP_000235683.1; NC_011601.1.
DR   EnsemblBacteria; CAS07621; CAS07621; E2348C_0073.
DR   KEGG; ecg:E2348C_0073; -.
DR   HOGENOM; HOG000272487; -.
DR   KO; K02063; -.
DR   OMA; SYLWHVI; -.
DR   BioCyc; ECOL574521:E2348C_RS00375-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   GO; GO:0015888; P:thiamine transport; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 2.
DR   Gene3D; 1.10.3720.10; -; 2.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   InterPro; IPR005947; ThiP_ABC_transpt.
DR   Pfam; PF00528; BPD_transp_1; 2.
DR   SUPFAM; SSF161098; SSF161098; 2.
DR   TIGRFAMs; TIGR01253; thiP; 1.
DR   PROSITE; PS50928; ABC_TM1; 2.
PE   3: Inferred from homology;
DR   PRODOM; B7UIB8.
DR   SWISS-2DPAGE; B7UIB8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Membrane {ECO:0000256|RuleBase:RU363032,
KW   ECO:0000256|SAAS:SAAS00819239};
KW   Transmembrane {ECO:0000256|RuleBase:RU363032,
KW   ECO:0000256|SAAS:SAAS00819262};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363032,
KW   ECO:0000256|SAAS:SAAS00819286};
KW   Transport {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM     12     38       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM     58     80       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM     92    114       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    134    151       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    199    220       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    240    260       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    289    311       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    331    354       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    375    394       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    406    424       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    465    484       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   TRANSMEM    504    525       Helical. {ECO:0000256|RuleBase:RU363032}.
FT   DOMAIN       56    261       ABC transmembrane type-1.
FT                                {ECO:0000259|PROSITE:PS50928}.
FT   DOMAIN      331    525       ABC transmembrane type-1.
FT                                {ECO:0000259|PROSITE:PS50928}.
SQ   SEQUENCE   536 AA;  59505 MW;  9E2A26CC6978BE81 CRC64;
     MATRRQPLIP GWLIPGVSAA TLVVAVALAA FLALWWNAPQ GDWVSVWQDS YLWHVVRFSF
     WQAFLSALLS VVPAIFLARA LYRRRFPGRQ MLLRLCAMTL ILPVLVAVFG ILSVYGRQGW
     LASLWQSLGL EWTFSPYGLQ GILLAHVFFN LPMASRLLLQ ALENIPGEQR QLAAQLGMRG
     WHFFRFVEWP WLRRQIPPVA ALIFMLCFAS FATVLSLGGG PQATTIELAI YQALSYDYDP
     ARAAMLALIQ MVCCLGLVLL SQRLSKAIAP GTTLLQGWRD PDDRLHSRIC DTALIVLALL
     LLLPPLLAVI VDGVNRQLPE VLAQPVLWQA LWTSLRIALA AGVLCVVLTM MLLWSSRELR
     ARQKMLAGQA LEMSGMLILA MPGIVLATGF FLLLNNTIGL PQSADGIVIF TNALMAIPYA
     LKVLENPMRD ITARYSMLCQ SLGIEGWSRL KVVELRALKR PLAQALAFAC VLSIGDFGVV
     ALFGNDDFRT LPFYLYQQIG SYRSQDGAVT ALILLLLCFL LFTVIEKIPG RNVKTD
//

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