(data stored in ACNUC7421 zone)

SWISSPROT: B7UIE4_ECO27

ID   B7UIE4_ECO27            Unreviewed;       420 AA.
AC   B7UIE4;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 64.
DE   RecName: Full=Cell division protein FtsA {ECO:0000256|HAMAP-Rule:MF_02033, ECO:0000256|PIRNR:PIRNR003101};
GN   Name=ftsA {ECO:0000256|HAMAP-Rule:MF_02033,
GN   ECO:0000313|EMBL:CAS07647.1};
GN   OrderedLocusNames=E2348C_0099 {ECO:0000313|EMBL:CAS07647.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07647.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07647.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Cell division protein that is involved in the assembly
CC       of the Z ring. May serve as a membrane anchor for the Z ring.
CC       {ECO:0000256|HAMAP-Rule:MF_02033, ECO:0000256|PIRNR:PIRNR003101}.
CC   -!- SUBUNIT: Interacts with FtsZ. {ECO:0000256|PIRNR:PIRNR003101}.
CC   -!- SUBUNIT: Self-interacts. Interacts with FtsZ. {ECO:0000256|HAMAP-
CC       Rule:MF_02033}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_02033}; Peripheral membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_02033}; Cytoplasmic side {ECO:0000256|HAMAP-
CC       Rule:MF_02033}. Note=Localizes to the Z ring in an FtsZ-dependent
CC       manner. Targeted to the membrane through a conserved C-terminal
CC       amphiphatic helix. {ECO:0000256|HAMAP-Rule:MF_02033}.
CC   -!- SIMILARITY: Belongs to the FtsA/MreB family. {ECO:0000256|HAMAP-
CC       Rule:MF_02033, ECO:0000256|PIRNR:PIRNR003101}.
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DR   EMBL; FM180568; CAS07647.1; -; Genomic_DNA.
DR   RefSeq; WP_000588474.1; NC_011601.1.
DR   SMR; B7UIE4; -.
DR   EnsemblBacteria; CAS07647; CAS07647; E2348C_0099.
DR   KEGG; ecg:E2348C_0099; -.
DR   HOGENOM; HOG000049205; -.
DR   KO; K03590; -.
DR   OMA; VIPFGGN; -.
DR   BioCyc; ECOL574521:E2348C_RS00510-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0032153; C:cell division site; IEA:UniProtKB-UniRule.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_02033; FtsA; 1.
DR   InterPro; IPR020823; Cell_div_FtsA.
DR   InterPro; IPR003494; SHS2_FtsA.
DR   Pfam; PF02491; SHS2_FTSA; 1.
DR   PIRSF; PIRSF003101; FtsA; 1.
DR   SMART; SM00842; FtsA; 1.
DR   TIGRFAMs; TIGR01174; ftsA; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UIE4.
DR   SWISS-2DPAGE; B7UIE4.
KW   ATP-binding {ECO:0000313|EMBL:CAS07647.1};
KW   Cell cycle {ECO:0000256|HAMAP-Rule:MF_02033,
KW   ECO:0000256|PIRNR:PIRNR003101};
KW   Cell division {ECO:0000256|HAMAP-Rule:MF_02033,
KW   ECO:0000256|PIRNR:PIRNR003101, ECO:0000313|EMBL:CAS07647.1};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_02033};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_02033};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_02033};
KW   Nucleotide-binding {ECO:0000313|EMBL:CAS07647.1}.
FT   DOMAIN       10    196       FtsA. {ECO:0000259|SMART:SM00842}.
FT   COILED       51     71       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   420 AA;  45330 MW;  C2475377A229B982 CRC64;
     MIKATDRKLV VGLEIGTAKV AALVGEVLPD GMVNIIGVGS CPSRGMDKGG VNDLESVVKC
     VQRAIDQAEL MADCQISSVY LALSGKHISC QNEIGMVPIS EEEVTQEDVE NVVHTAKSVR
     VRDEHRVLHV IPQEYAIDYQ EGIKNPVGLS GVRMQAKVHL ITCHNDMAKN IVKAVERCGL
     KVDQLIFAGL ASSYSVLTED ERELGVCVVD IGGGTMDIAV YTGGALRHTK VIPYAGNVVT
     SDIAYAFGTP PSDAEAIKVR HGCALGSIVG KDESVEVPSV GGRPPRSLQR QTLAEVIEPR
     YTELLNLVNE EILQLQEKLR QQGVKHHLAA GIVLTGGAAQ IEGLAACAQR VFHTQVRIGA
     PLNITGLTDY AQEPYYSTAV GLLHYGKESH LNGEAEVEKR VTASVGSWIK RLNSWLRKEF
//

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