(data stored in ACNUC7421 zone)

SWISSPROT: SECM_ECO27

ID   SECM_ECO27              Reviewed;         170 AA.
AC   B7UIE7;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   05-DEC-2018, entry version 40.
DE   RecName: Full=Secretion monitor {ECO:0000255|HAMAP-Rule:MF_01332};
DE   Flags: Precursor;
GN   Name=secM {ECO:0000255|HAMAP-Rule:MF_01332};
GN   OrderedLocusNames=E2348C_0102;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Regulates secA expression by translational coupling of
CC       the secM secA operon. Translational pausing at a specific Pro
CC       residue 5 residues before the end of the protein may allow
CC       disruption of a mRNA repressor helix that normally suppresses secA
CC       translation initiation. {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-
CC       Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}.
CC       Note=The active form is cytosolic, while the periplasmic form is
CC       rapidly degraded, mainly by the tail-specific protease.
CC       {ECO:0000255|HAMAP-Rule:MF_01332}.
CC   -!- SIMILARITY: Belongs to the SecM family. {ECO:0000255|HAMAP-
CC       Rule:MF_01332}.
DR   EMBL; FM180568; CAS07650.1; -; Genomic_DNA.
DR   RefSeq; WP_000014318.1; NC_011601.1.
DR   PRIDE; B7UIE7; -.
DR   EnsemblBacteria; CAS07650; CAS07650; E2348C_0102.
DR   KEGG; ecg:E2348C_0102; -.
DR   KO; K13301; -.
DR   OMA; NYWQQHA; -.
DR   BioCyc; ECOL574521:E2348C_RS00525-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   HAMAP; MF_01332; SecM; 1.
DR   InterPro; IPR009502; SecM.
DR   Pfam; PF06558; SecM; 1.
DR   PIRSF; PIRSF004572; SecM; 1.
DR   ProDom; PD089227; SecM; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UIE7.
DR   SWISS-2DPAGE; B7UIE7.
KW   Complete proteome; Cytoplasm; Periplasm; Signal.
FT   SIGNAL        1     37       {ECO:0000255|HAMAP-Rule:MF_01332}.
FT   CHAIN        38    170       Secretion monitor.
FT                                /FTId=PRO_1000166095.
SQ   SEQUENCE   170 AA;  18875 MW;  5B4B30011A51AD22 CRC64;
     MSGILTRWRQ FGKRYFWPHL LLGMVAASLG LPALSNAAEP NAPAKATTRN HEPSAKVNFG
     QLALLEANTR RPNSNYSVDY WHQHAIRTVI RHLSFAMAPQ TLPVAEESLP LQAQHLALLD
     TLSALLTQEG TPSEKGYRID YAHFTPQAKF STPVWISHAQ GIRAGPQRLS
//

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