(data stored in ACNUC7421 zone)

SWISSPROT: B7UII9_ECO27

ID   B7UII9_ECO27            Unreviewed;       151 AA.
AC   B7UII9;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 59.
DE   RecName: Full=RNA polymerase-binding transcription factor DksA {ECO:0000256|HAMAP-Rule:MF_00926};
GN   Name=dksA {ECO:0000256|HAMAP-Rule:MF_00926,
GN   ECO:0000313|EMBL:CAS07696.1};
GN   OrderedLocusNames=E2348C_0148 {ECO:0000313|EMBL:CAS07696.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07696.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07696.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Transcription factor that acts by binding directly to
CC       the RNA polymerase (RNAP). Required for negative regulation of
CC       rRNA expression and positive regulation of several amino acid
CC       biosynthesis promoters. Also required for regulation of fis
CC       expression. {ECO:0000256|HAMAP-Rule:MF_00926}.
CC   -!- SUBUNIT: Interacts directly with the RNA polymerase.
CC       {ECO:0000256|HAMAP-Rule:MF_00926}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00926}.
CC   -!- SIMILARITY: Belongs to the DksA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00926}.
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DR   EMBL; FM180568; CAS07696.1; -; Genomic_DNA.
DR   RefSeq; WP_001155227.1; NC_011601.1.
DR   SMR; B7UII9; -.
DR   EnsemblBacteria; CAS07696; CAS07696; E2348C_0148.
DR   GeneID; 29459173; -.
DR   KEGG; ecg:E2348C_0148; -.
DR   HOGENOM; HOG000178407; -.
DR   KO; K06204; -.
DR   OMA; AQERHEK; -.
DR   BioCyc; ECOL574521:E2348C_RS00765-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00926; DksA; 1.
DR   InterPro; IPR012784; DksA_RNA_pol-bd.
DR   InterPro; IPR037187; DnaK_N.
DR   InterPro; IPR020460; Znf_C4-type_bac.
DR   InterPro; IPR000962; Znf_DskA_TraR.
DR   InterPro; IPR020458; Znf_DskA_TraR_CS.
DR   Pfam; PF01258; zf-dskA_traR; 1.
DR   PRINTS; PR00618; DKSAZNFINGER.
DR   SUPFAM; SSF109635; SSF109635; 1.
DR   TIGRFAMs; TIGR02420; dksA; 1.
DR   PROSITE; PS01102; ZF_DKSA_1; 1.
DR   PROSITE; PS51128; ZF_DKSA_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UII9.
DR   SWISS-2DPAGE; B7UII9.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00926};
KW   DNA-binding {ECO:0000313|EMBL:CAS07696.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00926};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00926};
KW   Zinc-finger {ECO:0000256|HAMAP-Rule:MF_00926}.
FT   DOMAIN       71    151       DksA C4-type. {ECO:0000259|PROSITE:
FT                                PS51128}.
FT   ZN_FING     114    138       dksA C4-type. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00510}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
FT   METAL       114    114       Zinc. {ECO:0000256|HAMAP-Rule:MF_00926}.
FT   METAL       117    117       Zinc. {ECO:0000256|HAMAP-Rule:MF_00926}.
FT   METAL       135    135       Zinc. {ECO:0000256|HAMAP-Rule:MF_00926}.
FT   METAL       138    138       Zinc. {ECO:0000256|HAMAP-Rule:MF_00926}.
SQ   SEQUENCE   151 AA;  17528 MW;  620842DB15E066A9 CRC64;
     MQEGQNRKTS SLSILAIAGV EPYQEKPGEE YMNEAQLAHF RRILEAWRNQ LRDEVDRTVT
     HMQDEAANFP DPVDRAAQEE EFSLELRNRD RERKLIKKIE KTLKKVEDED FGYCESCGVE
     IGIRRLEARP TADLCIDCKT LAEIREKQMA G
//

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