(data stored in ACNUC7421 zone)

SWISSPROT: B7UIM1_ECO27

ID   B7UIM1_ECO27            Unreviewed;       450 AA.
AC   B7UIM1;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 69.
DE   RecName: Full=Zinc metalloprotease {ECO:0000256|RuleBase:RU362031};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU362031};
GN   Name=yaeL {ECO:0000313|EMBL:CAS07729.1};
GN   OrderedLocusNames=E2348C_0181 {ECO:0000313|EMBL:CAS07729.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07729.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07729.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU362031,
CC         ECO:0000256|SAAS:SAAS00913187};
CC   -!- SIMILARITY: Belongs to the peptidase M50B family.
CC       {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00563376}.
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DR   EMBL; FM180568; CAS07729.1; -; Genomic_DNA.
DR   RefSeq; WP_001339560.1; NC_011601.1.
DR   EnsemblBacteria; CAS07729; CAS07729; E2348C_0181.
DR   KEGG; ecg:E2348C_0181; -.
DR   HOGENOM; HOG000006281; -.
DR   KO; K11749; -.
DR   OMA; MFLGLFN; -.
DR   BioCyc; ECOL574521:E2348C_RS00935-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR041489; PDZ_6.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR004387; Pept_M50_Zn.
DR   InterPro; IPR008915; Peptidase_M50.
DR   Pfam; PF17820; PDZ_6; 1.
DR   Pfam; PF02163; Peptidase_M50; 1.
DR   SMART; SM00228; PDZ; 2.
DR   SUPFAM; SSF50156; SSF50156; 2.
DR   TIGRFAMs; TIGR00054; TIGR00054; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UIM1.
DR   SWISS-2DPAGE; B7UIM1.
KW   Cell membrane {ECO:0000256|SAAS:SAAS00462286};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Hydrolase {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069908};
KW   Membrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069850};
KW   Metal-binding {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00913207};
KW   Metalloprotease {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069945, ECO:0000313|EMBL:CAS07729.1};
KW   Protease {ECO:0000256|SAAS:SAAS00069928, ECO:0000313|EMBL:CAS07729.1};
KW   Transmembrane {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069900};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362031,
KW   ECO:0000256|SAAS:SAAS00069864};
KW   Zinc {ECO:0000256|RuleBase:RU362031, ECO:0000256|SAAS:SAAS00090197}.
FT   TRANSMEM      6     29       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM     98    119       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    376    396       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   TRANSMEM    426    444       Helical. {ECO:0000256|RuleBase:RU362031}.
FT   DOMAIN      199    291       PDZ. {ECO:0000259|PROSITE:PS50106}.
SQ   SEQUENCE   450 AA;  49069 MW;  321AA0FA1F5C70BB CRC64;
     MLSFLWDLAS FIVALGVLIT VHEFGHFWVA RRCGVRVERF SIGFGKALWR RTDKLGTEYV
     IALIPLGGYV KMLDERAEPV VPELRHHAFN NKSVGQRAAI IAAGPVANFI FAIFAYWLVF
     IIGVPGVRPV VGEIAANSIA AEAQIAPGTE LKAVDGIETP DWDAVRLQLV DKIGDESTTI
     TVAPFGSDQR RDVKLDLRHW AFEPDKEDPV SSLGIRPRGP QIEPVLENVQ PNSAASKAGL
     QAGDRIVKVD GQPLTQWVTF VMLVRDNPGK SLALEIERQG SPLSLALIPE SKPGNGKAIG
     FVGIEPKVIP LPDEYKVVRQ YGPFNAIVEA TDKTWQLMKL TVSMLGKLIT GDVKLNNLSG
     PISIAKGAGM TAELGVVYYL PFLALISVNL GIINLFPLPV LDGGHLLFLV IEKIKGGPVS
     ERVQDFCYRI GSILLVLLMG LALFNDFSRL
//

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