(data stored in ACNUC7421 zone)

SWISSPROT: ECPD_ECO27

ID   ECPD_ECO27              Reviewed;         547 AA.
AC   B7UJD8;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   05-DEC-2018, entry version 36.
DE   RecName: Full=Fimbria adhesin EcpD;
DE   Flags: Precursor;
GN   Name=ecpD; OrderedLocusNames=E2348C_0246;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
RN   [2]
RP   INDUCTION.
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=22797761; DOI=10.1128/JB.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS
RT   in attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
RN   [3]
RP   FUNCTION, SUBUNIT, INTERACTION WITH ECPA, AND SUBCELLULAR LOCATION.
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=22355107; DOI=10.1073/pnas.1106733109;
RA   Garnett J.A., Martinez-Santos V.I., Saldana Z., Pape T., Hawthorne W.,
RA   Chan J., Simpson P.J., Cota E., Puente J.L., Giron J.A., Matthews S.;
RT   "Structural insights into the biogenesis and biofilm formation by the
RT   Escherichia coli common pilus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:3950-3955(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
CC       common pilus (ECP). ECP is found in both commensal and pathogenic
CC       strains and plays a dual role in early-stage biofilm development
CC       and host cell recognition. Tip pilus adhesin, which is required
CC       for assembly of EcpA into fibers. {ECO:0000269|PubMed:22355107}.
CC   -!- SUBUNIT: Forms polymers. Interacts with EcpA.
CC       {ECO:0000269|PubMed:22355107}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000269|PubMed:22355107}.
CC       Note=Polymerized EcpD is normally incorporated within the tip of
CC       ECP, but it can also form functional fimbria independent of EcpA.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by
CC       IHF and EcpR. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpD/MatE family. {ECO:0000305}.
DR   EMBL; FM180568; CAS07794.1; -; Genomic_DNA.
DR   RefSeq; WP_001265644.1; NC_011601.1.
DR   EnsemblBacteria; CAS07794; CAS07794; E2348C_0246.
DR   KEGG; ecg:E2348C_0246; -.
DR   HOGENOM; HOG000269468; -.
DR   KO; K21967; -.
DR   OMA; SRAGLSC; -.
DR   BioCyc; ECOL574521:E2348C_RS01305-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
DR   PRODOM; B7UJD8.
DR   SWISS-2DPAGE; B7UJD8.
KW   Complete proteome; Fimbrium; Signal.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    547       Fimbria adhesin EcpD.
FT                                /FTId=PRO_0000429534.
SQ   SEQUENCE   547 AA;  59948 MW;  DF9554EBCA9C5CF4 CRC64;
     MRVNLLIAMI IFALIWPATA LRAAVSKTTW ADAPAREFVF VENNSDDNFF VTPGGALDPR
     LTGANRWTGL KYNGSGTIYQ QSLGYIDNGY NTGLYTNWKF DMWLENSPVS SPLTGLRCIN
     WYAGCNMTTS LILPQTTDAS GFYGATVTSG GAKWMHGMLS DAFYQYLQQM PVGSSFTMTI
     NACQTSVNYD ASSGARCKDQ ASGNWYVRNV THTKAANLRL INTHSLAEVF INSDGVPTLG
     EGNADCRTQT IGSRSGLSCK MVNYTLQTNG LSNTSIHIFP AIANSSLASA VGAYDMQFSL
     NGSSWKPVSN TAYYYTFNEM KSADSIYVFF SSNFFKQMVN LGISDINTKD LFNFRFQNTT
     SPESGWYEFS TSNTLIIKPR DFSISIISDE YTQTPSREGY VASGESALDF GYIVTTSGKT
     AADEVLIKVT GPAQVIGGRS YCVFSSDDGK AKVPFPATLS FITRNGATKT YDAGCDDSWR
     DMTDALWLTT PWTDISGEVG QMDKTTVKFS IPMDNAISLR TVDDNGWFGE VSASGEIHVQ
     ATWRNIN
//

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