(data stored in ACNUC7421 zone)

SWISSPROT: ECPB_ECO27

ID   ECPB_ECO27              Reviewed;         222 AA.
AC   B7UJE0;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 44.
DE   RecName: Full=Probable fimbrial chaperone EcpB;
DE   Flags: Precursor;
GN   Name=ecpB; OrderedLocusNames=E2348C_0248;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
RN   [2]
RP   INDUCTION.
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=22797761; DOI=10.1128/JB.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS
RT   in attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli
CC       common pilus (ECP). ECP is found in both commensal and pathogenic
CC       strains and plays a dual role in early-stage biofilm development
CC       and host cell recognition (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by
CC       IHF and EcpR. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpB/EcpE family. {ECO:0000305}.
DR   EMBL; FM180568; CAS07796.1; -; Genomic_DNA.
DR   RefSeq; WP_000716404.1; NC_011601.1.
DR   SMR; B7UJE0; -.
DR   EnsemblBacteria; CAS07796; CAS07796; E2348C_0248.
DR   KEGG; ecg:E2348C_0248; -.
DR   HOGENOM; HOG000269492; -.
DR   KO; K21965; -.
DR   OMA; KENYFVM; -.
DR   BioCyc; ECOL574521:E2348C_RS01315-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR040695; EcpB_C.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008962; PapD-like_sf.
DR   Pfam; PF18649; EcpB_C; 1.
DR   SUPFAM; SSF49354; SSF49354; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; B7UJE0.
DR   SWISS-2DPAGE; B7UJE0.
KW   Chaperone; Complete proteome; Fimbrium biogenesis; Signal.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21    222       Probable fimbrial chaperone EcpB.
FT                                /FTId=PRO_0000429478.
SQ   SEQUENCE   222 AA;  24501 MW;  F32908C77A181872 CRC64;
     MKKHLLPLAL LFSGISPAQA LDVGDISSFM NSDSSTLSKT IQNSTDSGRL INIRLERLSS
     PLDDGQVIAM DKPDELLLTP ASLLLPAQAS EVIRFFYKGP ADEKERYYRI VWFDQALSDA
     QRDNANRSAV ATASARIGTI LVVAPRQANY HFQYANGSLT NTGNATLRIL AYGPCLKAAN
     GKECKENYYL MPGKSRRFTR VDTADNKGRV ALWQGDKFIP VK
//

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