(data stored in ACNUC7421 zone)

SWISSPROT: B7UJF1_ECO27

ID   B7UJF1_ECO27            Unreviewed;       283 AA.
AC   B7UJF1;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 53.
DE   SubName: Full=Predicted aldo/keto reductases, related to diketogulonate reductase {ECO:0000313|EMBL:CAS07808.1};
GN   OrderedLocusNames=E2348C_0260 {ECO:0000313|EMBL:CAS07808.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07808.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07808.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
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DR   EMBL; FM180568; CAS07808.1; -; Genomic_DNA.
DR   RefSeq; WP_001174468.1; NC_011601.1.
DR   EnsemblBacteria; CAS07808; CAS07808; E2348C_0260.
DR   KEGG; ecg:E2348C_0260; -.
DR   HOGENOM; HOG000250272; -.
DR   KO; K06221; -.
DR   OMA; RKEMWQA; -.
DR   BioCyc; ECOL574521:E2348C_RS01370-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   CDD; cd06660; Aldo_ket_red; 1.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR020471; Aldo/keto_reductase.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; PTHR43827; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE   4: Predicted;
DR   PRODOM; B7UJF1.
DR   SWISS-2DPAGE; B7UJF1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205}.
FT   DOMAIN       16    257       Aldo_ket_red. {ECO:0000259|Pfam:PF00248}.
FT   ACT_SITE     49     49       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000097-1}.
FT   BINDING     107    107       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000097-2}.
FT   SITE         74     74       Lowers pKa of active site Tyr.
FT                                {ECO:0000256|PIRSR:PIRSR000097-3}.
SQ   SEQUENCE   283 AA;  31897 MW;  BFD4C72B7A94BF48 CRC64;
     MQKVKLNNGI EMPLLGFGVF QMTDAAECER AVIDAINTGY RLIDTAASYQ NETQVGNALK
     RSGIARNELF VTTKLWLQDT SYEGAKAQFE RSLNRLQLDY VDLYLIHQPY GDVHGAWRAM
     EELQQAGKIR AIGVSNFHPD RLADLIAFNN VVPAVNQVEV NPFNQQLQAV PWMQSRGIQP
     EAWAPFAEGK NGLFQHPVLT AIGEKYGKSV GQVVLRWIYQ RGVVSLAKSV RKERMEENIN
     ILDFELSPED MLQITALDTA TSAFFSHRDP AMVEWLTGRK LDV
//

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