(data stored in ACNUC7421 zone)

SWISSPROT: BETI_ECO27

ID   BETI_ECO27              Reviewed;         195 AA.
AC   B7UJG6;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   Name=betI {ECO:0000255|HAMAP-Rule:MF_00768};
GN   OrderedLocusNames=E2348C_0275;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Repressor involved in the biosynthesis of the
CC       osmoprotectant glycine betaine. It represses transcription of the
CC       choline transporter BetT and the genes of BetAB involved in the
CC       synthesis of glycine betaine (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway [regulation].
DR   EMBL; FM180568; CAS07823.1; -; Genomic_DNA.
DR   RefSeq; WP_001313612.1; NC_011601.1.
DR   SMR; B7UJG6; -.
DR   EnsemblBacteria; CAS07823; CAS07823; E2348C_0275.
DR   KEGG; ecg:E2348C_0275; -.
DR   KO; K02167; -.
DR   OMA; EMEVWFA; -.
DR   BioCyc; ECOL574521:E2348C_RS01445-MONOMER; -.
DR   UniPathway; UPA00529; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00768; HTH_type_BetI; 1.
DR   InterPro; IPR039538; BetI_C.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR   InterPro; IPR017757; Tscrpt_rep_BetI.
DR   Pfam; PF13977; TetR_C_6; 1.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF48498; SSF48498; 1.
DR   TIGRFAMs; TIGR03384; betaine_BetI; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UJG6.
DR   SWISS-2DPAGE; B7UJG6.
KW   Complete proteome; DNA-binding; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    195       HTH-type transcriptional regulator BetI.
FT                                /FTId=PRO_1000148445.
FT   DOMAIN        8     68       HTH tetR-type. {ECO:0000255|HAMAP-
FT                                Rule:MF_00768}.
FT   DNA_BIND     31     50       H-T-H motif. {ECO:0000255|HAMAP-
FT                                Rule:MF_00768}.
SQ   SEQUENCE   195 AA;  21818 MW;  4F2C7A6A829614E6 CRC64;
     MPKLGMQSIR RRQLIDATLE AINEVGMHDA TIAQIARRAG VSTGIISHYF RDKNGLLEAT
     MRDITSQLRD AVLNRLHALP QGSAERRLQA IVGGNFDETQ VSSAAMKAWL AFWASSMHQP
     MLYRLQQVSS RRLLSNLVSE FRRELPRQQA QEAGYGLAAL IDGLWLRAAL SGKPLDKPLA
     HSLTRHFITQ HLPTD
//

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