(data stored in ACNUC7421 zone)

SWISSPROT: B7UJI0_ECO27

ID   B7UJI0_ECO27            Unreviewed;       528 AA.
AC   B7UJI0;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 70.
DE   SubName: Full=DNA-binding transcriptional activator {ECO:0000313|EMBL:CAS07838.1};
GN   Name=prpR {ECO:0000313|EMBL:CAS07838.1};
GN   OrderedLocusNames=E2348C_0290 {ECO:0000313|EMBL:CAS07838.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07838.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07838.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
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DR   EMBL; FM180568; CAS07838.1; -; Genomic_DNA.
DR   RefSeq; WP_000941085.1; NC_011601.1.
DR   EnsemblBacteria; CAS07838; CAS07838; E2348C_0290.
DR   KEGG; ecg:E2348C_0290; -.
DR   HOGENOM; HOG000058487; -.
DR   KO; K02688; -.
DR   OMA; IMLYARS; -.
DR   BioCyc; ECOL574521:E2348C_RS01530-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008134; F:transcription factor binding; IEA:InterPro.
DR   GO; GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR012704; Sig_transdc_resp-reg_PrpR.
DR   InterPro; IPR010524; Sig_transdc_resp-reg_PrpR_N.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF06506; PrpR_N; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   PRINTS; PR01590; HTHFIS.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02329; propionate_PrpR; 1.
DR   PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   4: Predicted;
DR   PRODOM; B7UJI0.
DR   SWISS-2DPAGE; B7UJI0.
KW   ATP-binding {ECO:0000256|SAAS:SAAS00473007};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   DNA-binding {ECO:0000256|SAAS:SAAS00814512,
KW   ECO:0000313|EMBL:CAS07838.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00473126};
KW   Transcription {ECO:0000256|SAAS:SAAS00814760};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00814754}.
FT   DOMAIN      218    460       Sigma-54 factor interaction.
FT                                {ECO:0000259|PROSITE:PS50045}.
SQ   SEQUENCE   528 AA;  58485 MW;  7061A4ACDEDE7487 CRC64;
     MAHPPRLNDD KPVIWTVSVT RLFELFRDIS LEFDHLANIT PIQLGFEKAV TYIRKKLASE
     RCDAIIAAGS NGAYLKSRLS VPVILIKPSG YDVLQALAKA GKLTSSIGVV TYQETIPALV
     AFQKTFNLRL DQRSYITEED ARGQINELKA NGTEAVVGAG LITDLAEEAG MTGIFIYSAA
     TVRQAFSDAL DMTRMSLRHN THDATRNALR TRYVLGDMLG QSPQMEQVRQ TILLYARSSA
     AVLIEGETGT GKELAAQAIH REYFARHDAR QGKKSHPFVA VNCGAIAESL LEAELFGYEE
     GAFTGSRRGG RAGLFEIAHG GTLFLDEIGE MPLPLQTRLL RVLEEKEVTR VGGHQPVPVD
     VRVISATHCN LEEDMQQGQF RRDLFYRLSI LRLQLPPLRE RVADILPLAE SFLKVSLAAL
     SAPFAAALRQ GLQASETMLV HYDWPGNIRE LRNMMERLAL FLSVESTPDL TPQFLQLLLP
     ELARESAKTP IPGLLTAQQA LEKFNGDKTA AANYLGISRT TFWRRLKS
//

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