(data stored in ACNUC7421 zone)

SWISSPROT: B7UJI8_ECO27

ID   B7UJI8_ECO27            Unreviewed;       417 AA.
AC   B7UJI8;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 51.
DE   SubName: Full=Lactose/galactose transporter {ECO:0000313|EMBL:CAS07846.1};
GN   Name=lacY {ECO:0000313|EMBL:CAS07846.1};
GN   OrderedLocusNames=E2348C_0298 {ECO:0000313|EMBL:CAS07846.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07846.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07846.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
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DR   EMBL; FM180568; CAS07846.1; -; Genomic_DNA.
DR   RefSeq; WP_000291549.1; NC_011601.1.
DR   SMR; B7UJI8; -.
DR   EnsemblBacteria; CAS07846; CAS07846; E2348C_0298.
DR   KEGG; ecg:E2348C_0298; -.
DR   HOGENOM; HOG000114363; -.
DR   KO; K02532; -.
DR   OMA; IVGCFKY; -.
DR   BioCyc; ECOL574521:E2348C_RS01570-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   CDD; cd06174; MFS; 1.
DR   InterPro; IPR000576; LacY/RafB_perm_fam.
DR   InterPro; IPR018457; LacY/RafB_perm_fam_CS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF01306; LacY_symp; 1.
DR   PRINTS; PR00174; LACYSMPORT.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00882; 2A0105; 1.
DR   PROSITE; PS00896; LACY_1; 1.
DR   PROSITE; PS00897; LACY_2; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   4: Predicted;
DR   PRODOM; B7UJI8.
DR   SWISS-2DPAGE; B7UJI8.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     12     34       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     46     66       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     75     95       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    101    122       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    143    162       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    168    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    239       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    259    279       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    349    369       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    381    401       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        8    404       MFS. {ECO:0000259|PROSITE:PS50850}.
SQ   SEQUENCE   417 AA;  46503 MW;  24A8062F628CDA32 CRC64;
     MYYLKNTNFW MFGLFFFFYF FIMGAYFPFF PIWLHDINHI SKSDTGIIFA AISLFSLLFQ
     PLFGLLSDKL GLRKYLLWII TGMLVMFAPF FIFIFGPLLQ YNILVGSIVG GIYLGFCFNA
     GAPAVEAFIE KVSRRSNFEF GRARMFGCVG WALCASIVGI MFTINNQFVF WLGSGCALIL
     AVLLFFAKTD APSSATVANA VGANHSAFSL KLALELFRQP KLWFLSLYVI GVSCTYDVFD
     QQFANFFTSF FATGEQGTRV FGYVTTMGEL LNASIMFFAP LIINRIGGKN ALLLAGTIMS
     VRIIGSSFAT SALEVVILKT LHMFEVPFLL VGCFKYITSQ FEVRFSATIY LVCFCFFKQL
     AMIFMSVLAG NMYESIGFQG AYLVLGLVAL GFTLISVFTL SGPGPLSLLR RQVNEVA
//

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