(data stored in ACNUC7421 zone)

SWISSPROT: B7UKE3_ECO27

ID   B7UKE3_ECO27            Unreviewed;       397 AA.
AC   B7UKE3;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 48.
DE   SubName: Full=Multidrug efflux system {ECO:0000313|EMBL:CAS07946.1};
GN   Name=acrA {ECO:0000313|EMBL:CAS07946.1};
GN   OrderedLocusNames=E2348C_0398 {ECO:0000313|EMBL:CAS07946.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07946.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07946.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- SIMILARITY: Belongs to the membrane fusion protein (MFP)
CC       (TC 8.A.1) family. {ECO:0000256|SAAS:SAAS00568556}.
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DR   EMBL; FM180568; CAS07946.1; -; Genomic_DNA.
DR   RefSeq; WP_001295833.1; NC_011601.1.
DR   EnsemblBacteria; CAS07946; CAS07946; E2348C_0398.
DR   KEGG; ecg:E2348C_0398; -.
DR   HOGENOM; HOG000158247; -.
DR   KO; K03585; -.
DR   OMA; QLTVKRY; -.
DR   BioCyc; ECOL574521:E2348C_RS02085-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005215; F:transporter activity; IEA:InterPro.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR032317; HlyD_D23.
DR   InterPro; IPR006143; RND_pump_MFP.
DR   Pfam; PF00529; HlyD; 1.
DR   Pfam; PF16576; HlyD_D23; 1.
DR   TIGRFAMs; TIGR01730; RND_mfp; 1.
PE   3: Inferred from homology;
DR   PRODOM; B7UKE3.
DR   SWISS-2DPAGE; B7UKE3.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    397       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5002862652.
FT   DOMAIN       63    293       HlyD_D23. {ECO:0000259|Pfam:PF16576}.
SQ   SEQUENCE   397 AA;  42167 MW;  0F9F6D5BC907A6AC CRC64;
     MNKNRGFTPL AVVLMLSGSL ALTGCDDKQA QQGGQQMPAV GVVTVKTEPL QITTELPGRT
     SAYRIAEVRP QVSGIILKRN FKEGSDIEAG VSLYQIDPAT YQAAYDSAKG DLAKAQAAAN
     IAQLTVNRYQ KLLGTQYISK QEYDQALADA QQANAAVTAA KAAVETARIN LAYTKVTSPI
     SGRIGKSNVT EGALVQNGQA TALATVQQLD PIYVDVTQSS NDFLRLKQEL ANGTLKQENG
     KAKVSLITSD GIKFPQDGTL EFSDVTVDQT TGSITLRAIF PNPDHTLLPG MFVRARLEEG
     LNPNAILVPQ QGVTRTPRGD ATVLVVGADD KVETRPIVAS QAIGDKWLVT EGLKAGDRVV
     ISGLQKVRPG VQVKAQEVTA DNNQQAASGA QPEQSKS
//

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