(data stored in ACNUC7421 zone)

SWISSPROT: B7UKI7_ECO27

ID   B7UKI7_ECO27            Unreviewed;       292 AA.
AC   B7UKI7;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   SubName: Full=Tartronate semialdehyde reductase, NADH-dependent {ECO:0000313|EMBL:CAS07991.1};
GN   Name=glxR {ECO:0000313|EMBL:CAS07991.1};
GN   OrderedLocusNames=E2348C_0443 {ECO:0000313|EMBL:CAS07991.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS07991.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS07991.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
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DR   EMBL; FM180568; CAS07991.1; -; Genomic_DNA.
DR   RefSeq; WP_000765837.1; NC_011601.1.
DR   EnsemblBacteria; CAS07991; CAS07991; E2348C_0443.
DR   KEGG; ecg:E2348C_0443; -.
DR   HOGENOM; HOG000219608; -.
DR   KO; K00042; -.
DR   OMA; METPYPK; -.
DR   BioCyc; ECOL574521:E2348C_RS02325-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   InterPro; IPR006398; Tartro_sem_red.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01505; tartro_sem_red; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   4: Predicted;
DR   PRODOM; B7UKI7.
DR   SWISS-2DPAGE; B7UKI7.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205}.
FT   DOMAIN        2    160       NAD_binding_2. {ECO:0000259|Pfam:
FT                                PF03446}.
FT   DOMAIN      163    283       NAD_binding_11. {ECO:0000259|Pfam:
FT                                PF14833}.
FT   ACT_SITE    169    169       {ECO:0000256|PIRSR:PIRSR000103-1}.
SQ   SEQUENCE   292 AA;  30787 MW;  49EC78C2A132B05B CRC64;
     MKLGFIGLGI MGTPMAINLA RAGHQLHVTT IGPVADELLS LGAVSVETAR QVTEASDIIF
     IMVPDTPQVE DVLFGENGCT KASLKGKTIV DMSSISPIET KRFARQVNEL GGDYLDAPVS
     GGEIGAREGT LSIMVGGDEA VFERVKPLFE LLGKNITLVG GNGDGQTCKV ANQIIVALNI
     EAVSEALLFA SKAGADPVRV RQALMGGFAS SRILEVHGER MIKRTFNPGF KIALHQKDLN
     LALQSAKALA LNLPNTATCQ ELFNTCAANG GSQLDHSALV QALELMANHK LA
//

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