(data stored in ACNUC7421 zone)

SWISSPROT: B7UKL2_ECO27

ID   B7UKL2_ECO27            Unreviewed;       480 AA.
AC   B7UKL2;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   16-JAN-2019, entry version 70.
DE   RecName: Full=Sensor protein {ECO:0000256|RuleBase:RU364088};
DE            EC=2.7.13.3 {ECO:0000256|RuleBase:RU364088};
GN   Name=cusS {ECO:0000313|EMBL:CAS08018.1};
GN   OrderedLocusNames=E2348C_0470 {ECO:0000313|EMBL:CAS08018.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS08018.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS08018.1, ECO:0000313|Proteomes:UP000008205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: Member of a two-component regulatory system.
CC       {ECO:0000256|RuleBase:RU364088}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC         Evidence={ECO:0000256|RuleBase:RU364088,
CC         ECO:0000256|SAAS:SAAS01126420};
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU364088}.
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DR   EMBL; FM180568; CAS08018.1; -; Genomic_DNA.
DR   RefSeq; WP_000253812.1; NC_011601.1.
DR   EnsemblBacteria; CAS08018; CAS08018; E2348C_0470.
DR   KEGG; ecg:E2348C_0470; -.
DR   HOGENOM; HOG000126763; -.
DR   KO; K07644; -.
DR   OMA; ITETAQF; -.
DR   BioCyc; ECOL574521:E2348C_RS02475-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   CDD; cd06225; HAMP; 1.
DR   CDD; cd00075; HATPase_c; 1.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR006290; CztS_silS_copS.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR   Pfam; PF00672; HAMP; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   PRINTS; PR00344; BCTRLSENSOR.
DR   SMART; SM00304; HAMP; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR01386; cztS_silS_copS; 1.
DR   PROSITE; PS50885; HAMP; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
PE   4: Predicted;
DR   PRODOM; B7UKL2.
DR   SWISS-2DPAGE; B7UKL2.
KW   ATP-binding {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00925949};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU364088};
KW   Cell membrane {ECO:0000256|RuleBase:RU364088};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Kinase {ECO:0000256|RuleBase:RU364088, ECO:0000256|SAAS:SAAS01003914,
KW   ECO:0000313|EMBL:CAS08018.1};
KW   Membrane {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00925724};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00925310};
KW   Transferase {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS01003669};
KW   Transmembrane {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00926038};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00926160};
KW   Two-component regulatory system {ECO:0000256|RuleBase:RU364088,
KW   ECO:0000256|SAAS:SAAS00924981}.
FT   TRANSMEM     12     36       Helical. {ECO:0000256|RuleBase:RU364088}.
FT   TRANSMEM    187    206       Helical. {ECO:0000256|RuleBase:RU364088}.
FT   DOMAIN      207    260       HAMP. {ECO:0000259|PROSITE:PS50885}.
FT   DOMAIN      268    480       Histidine kinase. {ECO:0000259|PROSITE:
FT                                PS50109}.
SQ   SEQUENCE   480 AA;  53755 MW;  31AC58BD6374B9B9 CRC64;
     MVSKPFQRPF SLATRLTFFI SLATIAAFFA FAWIMIHSVK VHFAEQDIND LKEISATLER
     VLNHPDETQA RRLMTLEDIV SGYSNVLISL ADSHGKTVYH SPGAPDIREF ARDAIPDKDT
     RGGEVYLLSG PTIMMPGHGH GHMEHSNWRM ISLPVGPLVD GKPIYTLYIA LSIDFHLHYI
     NDLMNKLIMT ASVISILIVF IVLLAVHKGH APIRSVSRQI QNITSKDLDV RLDPQTVPIE
     LEQLVLSFNH MIERIEDVFT RQSNFSADIA HEIRTPITNL ITQTEIALSQ SRSQKELEDV
     HYSNLEELTR MAKMVSDMLF LAQADNNQLI PEKKMLNLAD EVGKVFDFFE ALAEDRGVEL
     RFVGDECQVA GDPLMLRRAL SNLLSNALRY TPTGETIVVR CQTVDHLVQV TVENPGTPIA
     PEHLPRLFDR FYRVDPSRQR KGEGSGIGLA IVKSIVVAHK GTVAVTSDAR GTRFVIILPA
//

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