(data stored in ACNUC7421 zone)


ID   B7ULN5_ECO27            Unreviewed;        49 AA.
AC   B7ULN5;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   08-MAY-2019, entry version 39.
DE   RecName: Full=Multidrug efflux pump accessory protein AcrZ {ECO:0000256|HAMAP-Rule:MF_01484};
DE   AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ {ECO:0000256|HAMAP-Rule:MF_01484};
DE   AltName: Full=Acridine resistance protein Z {ECO:0000256|HAMAP-Rule:MF_01484};
GN   Name=ybhT {ECO:0000313|EMBL:CAS08187.1};
GN   Synonyms=acrZ {ECO:0000256|HAMAP-Rule:MF_01484};
GN   OrderedLocusNames=E2348C_0639 {ECO:0000313|EMBL:CAS08187.1};
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521 {ECO:0000313|EMBL:CAS08187.1, ECO:0000313|Proteomes:UP000008205};
RN   [1] {ECO:0000313|EMBL:CAS08187.1, ECO:0000313|Proteomes:UP000008205}
RC   STRAIN=E2348/69 / EPEC {ECO:0000313|Proteomes:UP000008205};
RX   PubMed=18952797; DOI=10.1128/JB.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T.,
RA   Henderson I.R., Harris D., Asadulghani M., Kurokawa K., Dean P.,
RA   Kenny B., Quail M.A., Thurston S., Dougan G., Hayashi T., Parkhill J.,
RA   Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
CC   -!- FUNCTION: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex
CC       with a broad substrate specificity. This protein binds to AcrB and
CC       is required for efflux of some but not all substrates, suggesting
CC       it may influence the specificity of drug export.
CC       {ECO:0000256|HAMAP-Rule:MF_01484}.
CC   -!- SUBUNIT: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts
CC       directly with AcrB. {ECO:0000256|HAMAP-Rule:MF_01484}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC       Rule:MF_01484}; Single-pass membrane protein {ECO:0000256|HAMAP-
CC       Rule:MF_01484}.
CC   -!- SIMILARITY: Belongs to the AcrZ family. {ECO:0000256|HAMAP-
CC       Rule:MF_01484}.
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DR   EMBL; FM180568; CAS08187.1; -; Genomic_DNA.
DR   RefSeq; WP_000891515.1; NC_011601.1.
DR   SMR; B7ULN5; -.
DR   EnsemblBacteria; CAS08187; CAS08187; E2348C_0639.
DR   KEGG; ecg:E2348C_0639; -.
DR   HOGENOM; HOG000219534; -.
DR   BioCyc; ECOL574521:E2348C_RS03435-MONOMER; -.
DR   Proteomes; UP000008205; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015238; F:drug transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01484; AcrZ; 1.
DR   InterPro; IPR019702; AcrZ.
DR   Pfam; PF10766; AcrZ; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|HAMAP-Rule:MF_01484};
KW   Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_01484};
KW   Cell membrane {ECO:0000256|HAMAP-Rule:MF_01484};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008205};
KW   Membrane {ECO:0000256|HAMAP-Rule:MF_01484};
KW   Transmembrane {ECO:0000256|HAMAP-Rule:MF_01484};
KW   Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01484};
KW   Transport {ECO:0000256|HAMAP-Rule:MF_01484}.
FT   TRANSMEM      7     29       Helical. {ECO:0000256|HAMAP-Rule:
FT                                MF_01484}.
SQ   SEQUENCE   49 AA;  5300 MW;  1B1185D27F1F37F7 CRC64;

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