(data stored in SCRATCH zone)

SWISSPROT: C0H4R1_PLAF7

ID   C0H4R1_PLAF7            Unreviewed;      2279 AA.
AC   C0H4R1;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 66.
DE   SubName: Full=Adenylyl cyclase beta {ECO:0000313|EMBL:CAX64087.1};
DE            EC=4.6.1.1 {ECO:0000313|EMBL:CAX64087.1};
GN   ORFNames=PF3D7_0802600 {ECO:0000313|EMBL:CAX64087.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64087.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAX64087.1; -; Genomic_DNA.
DR   RefSeq; XP_002808810.1; XM_002808764.1.
DR   SMR; C0H4R1; -.
DR   PRIDE; C0H4R1; -.
DR   EnsemblProtists; CAX64087; CAX64087; PF3D7_0802600.
DR   GeneDB; PF3D7_0802600.1:pep; -.
DR   GeneID; 2655397; -.
DR   KEGG; pfa:PF3D7_0802600; -.
DR   EuPathDB; PlasmoDB:PF3D7_0802600; -.
DR   InParanoid; C0H4R1; -.
DR   OMA; NEREEQN; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0004016; F:adenylate cyclase activity; IDA:GeneDB.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009268; P:response to pH; IDA:GeneDB.
DR   Gene3D; 3.30.70.1230; -; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; SSF55073; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE   4: Predicted;
DR   PRODOM; C0H4R1.
DR   SWISS-2DPAGE; C0H4R1.
KW   Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000313|EMBL:CAX64087.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          114..173
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   DOMAIN          602..734
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          184..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          424..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1229..1338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1351..1399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1613..1642
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1921..2012
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          50..77
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        191..210
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        424..517
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        531..552
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1230..1251
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1263..1279
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1283..1297
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1312..1336
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1351..1366
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1921..1992
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1993..2012
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2279 AA;  269541 MW;  30F39A2D7859AE8A CRC64;
     MLKNIFSEYL KSYDNKDENY ERINNLSRNY SCDYTSDWRW FSIKCERFLE NELYKKYNKE
     EREKKKKNKN IIKENENLAI FRSFFPKILL NIYSKCENPA QFFSNLVIQK FNSVVFFCDA
     SGFSNLAEQL DKRINGTELL GNCLNKFFNI LIKIIDYWGG DIIKFSGDAV LVIWPLHNVL
     KNKKKKKKKN GTQNNDSDDE HVNLKDNKTS HDRYNLDKHI DMEKHKTNFE NFNLSNNHNN
     IHNIYNNDDD DYGDHQNEVY DNIKNYNLKN NKISKSNIAQ ANNSDDNYPS DYNKKKKNQN
     AVEIRKICLL ALGCCMDIHK LLNKFPTPIE NKYLKVHIAI TYGKVSFLQI GNVLRKREYL
     LSGKPLEEIG AGESLAKNGE SVLSYSFYKN IKDKVMVQGT CKKNFFLFVK MKEEIDMKKL
     KKNYEEEEEE QQQNEREEQN EREEQNEREE QNEREEQNER EEQNEREEQN EREEQNEREE
     QNKTEEQNKT EEQNKTEEQN KTEEQNKTEE QNKTEEQNKE GQLPNLLVDN RSVVKEEENI
     SKNNIKDNKR RNSLEDKIKK RFTLLSTDKQ SRQSTIIYEN FDLLLKTFIP DIVYRKLSLG
     CNIFFNEIRK VTIIFVSVKD IDASTMTGVH SAHGIMKLTQ KAVFTMEGTI NKFILDDKGI
     LILIMFGLPP LYHCDDTIRA LLTCFRLIDA LKSLKLNGSI GISTGKIWCG IIGNKIRKEY
     TALGDSVNVA ARLCFKAGNK EIYVDENTYN NCKHFISFQK LISIKVKGKN KLIKIYSPIG
     TINKKSIDYV YDNTSNDNNY FTDEELLVNN QNNKKNNNIL LNKEETIKNV HENLYTNIDL
     SIIQNKLIKT NYQQIFDFSF LNNNFLFIYY KSFFKNKIYH LFKEKNSFYY LQNLDTNNYK
     IITTTTFPNY SLNKNIEQIN NNHLIIKKDM DKQYVNNHQN LNHTIKQNQF ILHKDGNHIN
     SYDDFHGKSH SPSKSFSSIN NTYNNLLTYD MIYSLSRFNK IKTSLHVDYK SYTGPFLLHE
     YYDPFHFKFK ELSRIGGVLF VEGNENLGIF EFIKLITNGL YNFKLFNVSN MPNSLYINIT
     NPLLPWKILC NDILNTWKLS HMRKKNLLLN KNDNFNMLRE ITHPSYHWFF KSMIHVIDDL
     DIPFFKTKKK KKKKEKEKEK EYYNHKHKNY SYQTNKYIHN HTNKKNEHNL IQNKINTNTQ
     TQNASNNSNN NIFCQKISTF LEYFFHNSRR EKKKNKKKSK EKIKKKKKTL QDGKHIGNTN
     DMDAIYNGPS DVSHGSTWDK QCNNDDDDDD IHDDNHDDNH DDDDIHDDNH DDDDIHDDNH
     DGDDIHDDNH DGDDIHDDFH DDDDIHDDIH HDDNIHDDDN YNTPVRKHNV KKNKLTNKHE
     PSYPKHTATG DVSSSSHAYS RNDIQTKMKN ELKENRIGII SSMIYYFTLH ENMFIIFNYR
     SGTSLNINIE DDAWKISNNI AKLAMLKRKK ISKHLQKNLK DWRKNHSRKC DFCKGNFMNT
     TYVNNVHENN KCADNIYGNI TNLNNIYGDN TNDSFLHNND DDDNMYNSDK QNRLSFKKNI
     NDFLDDHMRA QSIDHVDKNI ISQIHNDINN DTNTNNIYNI NDMYNEENSH YSQNINITND
     NNNNNNKKNS SSSNNNNNNN DISAFSLKQQ KLYQAHEIIL MDENNDSSSK KSSSATLINN
     SEINSQIYNN ENIIHNTNKQ ENINVLQLFK EEKDIVNNTN KIKEQKMFYK TLCPNIKDNI
     LLYIAQQKMN EQNNNYQMNK NQNSKNNYLN DNIQNQINHL VKDNMDKHIY NNNNNNNNDN
     VYQNKSPLCN PFFMHKHKPL IFLFINGMKN NSNIKQLKKI KKYAQQCEAS IELKPFNKYD
     LYEFVSLCLN IHKDKISTQL IEYLNKTCFG IPKFVQYTLF YLLTNHYIEL YKYEKDKNDK
     HNYENNDELH PSVDARKNNE KNNEKNNEKN NEKNNEKNNE QNNEKNNEQN NEKNNEQNNE
     KNNEKNNEQK NEQKNQQKNQ QNNEQTNQQN NQHNNDEIFF LKEQKYEKDS SSTNPAKINH
     PNDITCANQF NQINNINQNY DKNNYINHFS KQIISVQNET VKSSVFPSNS TTSCNDNSNN
     DDINYEYDLV VVKDLNEAPL VPRLTAYCMS LIDSLNQEEQ LLAKLCSFFN NTFNIKKMEC
     IYPKYISRCE LKKIIVKLVE KNVFCLYEDP NKKSVTLPKD NVNSIHNINF VYRDMYNKIN
     SFLEKKSKHH SLFGKHKNVP DEEIYFCITN FSLKKVLNDL LENEEKEYIK KIYKKYIES
//

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