(data stored in ACNUC9543 zone)

SWISSPROT: C0H4R3_PLAF7

ID   C0H4R3_PLAF7            Unreviewed;       556 AA.
AC   C0H4R3;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 67.
DE   SubName: Full=U2 snRNA/tRNA pseudouridine synthase, putative {ECO:0000313|EMBL:CAX64089.1};
DE            EC=5.4.99.12 {ECO:0000313|EMBL:CAX64089.1};
GN   ORFNames=PF3D7_0804600 {ECO:0000313|EMBL:CAX64089.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64089.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAX64089.1; -; Genomic_DNA.
DR   RefSeq; XP_002808812.1; XM_002808766.1.
DR   EnsemblProtists; CAX64089; CAX64089; PF3D7_0804600.
DR   GeneDB; PF3D7_0804600.1:pep; -.
DR   GeneID; 2655322; -.
DR   KEGG; pfa:PF3D7_0804600; -.
DR   EuPathDB; PlasmoDB:PF3D7_0804600; -.
DR   HOGENOM; HOG000284479; -.
DR   InParanoid; C0H4R3; -.
DR   KO; K06173; -.
DR   OMA; VGTNYRG; -.
DR   PhylomeDB; C0H4R3; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0106029; F:tRNA pseudouridine synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:1990481; P:mRNA pseudouridine synthesis; IBA:GO_Central.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IBA:GO_Central.
DR   CDD; cd02568; PseudoU_synth_PUS1_PUS2; 1.
DR   Gene3D; 3.30.70.660; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR041708; PUS1/PUS2-like.
DR   PANTHER; PTHR11142; PTHR11142; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
PE   4: Predicted;
DR   PRODOM; C0H4R3.
DR   SWISS-2DPAGE; C0H4R3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Isomerase {ECO:0000313|EMBL:CAX64089.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN      385    481       PseudoU_synth_1. {ECO:0000259|Pfam:
FT                                PF01416}.
FT   COILED        5     46       {ECO:0000256|SAM:Coils}.
FT   COILED       74     94       {ECO:0000256|SAM:Coils}.
FT   COILED      191    225       {ECO:0000256|SAM:Coils}.
FT   COILED      283    311       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   556 AA;  66597 MW;  516AC18A6A007F19 CRC64;
     MENGNKKRLN NYEKNKERIK KLKLERQAIK KKEEEGKEKY ENEEKNNLNL KKYALCIGYI
     GSQYHGCQGQ GENCETIENT LERTLLKINA IKKKKFFKNF NFCLSRSART DQGVHALFNI
     FVYNVDINCT NMKNEEVHKT VNNSNDDHKT VNNNNDDHKT VNNNNDDHKT VTNNNNDHKT
     VNNNNNDENF CGMMENQKND QEKNYEELFK ERKEKEEKFK NLLNDHLPCD IKCFKIYKVT
     KSFDARKFCS FRFYEYLFPV YVLSEVQVNE KYKETFHQAI LDIDEYVQRC KEEKRTRRNN
     EKNHIDSTNK ENENIYFKNG DNIDSMNSTT NNNSKDFSCT KDNTEQPNIV ENIKRDIIDE
     DIFSIKHFKE DLNEEELNTF FDIFNNYVGY HNFHCFTKKK IDQTTYRFIK YFDVSTVKLF
     DYHFLSVKIL GQSFLMHQIR KMITLAVETY RKATSINSIY YCLNTKNYIP ITLFPSDGLM
     LICPYFNAYN EKVCKQPHTL PIYFEETEDI MEFKKNKIGK CIIEKMKQNV WKEWLQRINK
     HPFIYHFIKE KINSTI
//

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