(data stored in SCRATCH zone)

SWISSPROT: C0H4S2_PLAF7

ID   C0H4S2_PLAF7            Unreviewed;      1704 AA.
AC   C0H4S2;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 70.
DE   SubName: Full=Ferlin-like protein, putative {ECO:0000313|EMBL:CAX64098.1};
GN   ORFNames=PF3D7_0806300 {ECO:0000313|EMBL:CAX64098.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64098.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAX64098.1; -; Genomic_DNA.
DR   RefSeq; XP_002808821.1; XM_002808775.1.
DR   EnsemblProtists; CAX64098; CAX64098; PF3D7_0806300.
DR   GeneDB; PF3D7_0806300.1:pep; -.
DR   GeneID; 2655409; -.
DR   KEGG; pfa:PF3D7_0806300; -.
DR   EuPathDB; PlasmoDB:PF3D7_0806300; -.
DR   HOGENOM; HOG000283934; -.
DR   InParanoid; C0H4S2; -.
DR   OMA; HITHYDL; -.
DR   Reactome; R-PFA-9609523; Insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd04037; C2E_Ferlin; 1.
DR   Gene3D; 2.60.40.150; -; 5.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037724; C2E_Ferlin.
DR   InterPro; IPR012968; FerIin_dom.
DR   InterPro; IPR037721; Ferlin.
DR   PANTHER; PTHR12546; PTHR12546; 1.
DR   Pfam; PF00168; C2; 5.
DR   SMART; SM00239; C2; 4.
DR   SMART; SM01202; FerI; 1.
DR   PROSITE; PS50004; C2; 2.
PE   4: Predicted;
DR   PRODOM; C0H4S2.
DR   SWISS-2DPAGE; C0H4S2.
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1682..1703
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..100
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          670..754
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   REGION          433..457
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1013..1121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1029..1063
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1064..1079
FT                   /note="Polar"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1080..1119
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1704 AA;  197634 MW;  068F45EF263CC875 CRC64;
     MSSIAKKTQY NIKVDIHEVK DLSFRESANE KEIIPNPYIE VTVNNEKKST TKKNQAVNVV
     YNTSFNFSQD LTDYKFERTS VDVCVLHKYT IQSALIGKCS FGLNFVYSKV QHWLYRIWVK
     LRNPDLPLDD VGFLLISVGV YGPGDSIPIV NDSVKTDIHE DVFSNKGLDI HITHYDLCLN
     IFRGQDIELI GNSTLFSNIL EPYVKVSHNG FEECTKVIRN DPNPVWNLSI HIPTCTPCYD
     KNILVELING EHNGIVIYSI LLDFFEILKR ELAPRWFNIY YNPQNQIMPR YSEYMQNGSI
     QINLNSTTTN NNNNNSTAIN PLGNYLFSGA AEKIFKNATQ AININDILGV TKVQNMFTDD
     TLKEFYLYGG RIFLSANATK THSPGPICIK SAKVEVDAPN KEYIFCADIY EILSVRNNKM
     GNYDDYDGGY TTTNNNNKNK NNNNENNNND NNDNIYNSNN IYNSASEKRR SRYNNNYDAS
     GESIICVCAL GPHKLKTIPL LPNEVGSYVL NENVGRIDEF RIFLPQNNNE QIYDIFLYIY
     IKSNLAVTNW INNRRSIYNS VLLNNEYESG DRNKKQGLHK MGSINNISED IMQDSDFLNN
     YKLTSYVRIP YKYLLLNENK PKWFSMKNIE TNVHEYNISF FANLIPYHAY KKRPKRLEYK
     LSRYFFRALI YEGLHFPAKG YNAFPDPYIK IELAGQVIKT STILHTLNPN YYEAYEVQVI
     LPTNLNLAPD ISIEALSVNK SFLYNDDILL GSCTFPIMKV PTEWKKSPIW IPLKSSQYKK
     CKAKLLVAFE LVPVEKVLDD TYPFYDDIRP STLPGHVSLF LIGIRMFKPL KDPSVTVCFG
     RDVDDTSQFL WHETTNKVIS GKEGNWNFLK YFSLDVMLPK RMQHHSFLEV RIEDRILNSG
     FTGTASSNMH AVNATNNNLL IGTAYITLNP LLPWLDNYEK NECVELFKLH LLEEVLIEDA
     EMDRKSYNSA LIYKKSSIMS RKLSNDNFET QQMGEENGIF NDIPMNTLEE NVTIKGDDSS
     DDEKDNSYDD EKDNSYDDEK DNSYDDEKDN SYDGDDKSGH YYHTWEDNNN NNNNNVTSDH
     TCKHKNEHNN NKKEDEKRKR EKKNTYTTNH DKRENNNTHI NNNYKHVIDI KKKKRKKNIK
     KYINNEYVPY NDPDFSNVRI EETLEHVCFK INDLTKKENT YIYYNDEQET LCDSISSEKR
     KKLKDIHFFK GGKHDDKEKK STIIDGKQPT TIYGFNEDML NFQLSLADDD EQEEIQRDEM
     LYEYEVDMNT DDLPYLRATI FRCTDSGVPE AVGYLKYICN VYDEKTMYLK KEMIKKCDDL
     VREYRLTRNL VVRAYIIQAR GLNPPSGATD ITTYIWIKNS NDMTNIPGGL SHNIKDTGHT
     KKQGYKPEFN RCYQLLCSFP DESIVQVCIM NQGSLSDEII GYTYIDMEDR YFNQKIRQLM
     IDDLMPIELR SLKLENSTIS HGSLRCWFEI FNEEFAQLNP IKVLCSNEPD DYQLRLVIWK
     VNNAAMDDNS TISLFVRCIY TDEDREDIRD TDTHYNSKDG KGIFNWRFVY NIKIPTNATN
     IKIQIHNYAL LSSNEPIGEA TLDLSAHFYR ARKKKGYYPI PRFWLSCKHP AHKNKVRGNV
     EIEGSILIKS EAELDPVGNG RDEPNKDPYL PPVTENRTYV DWVMINEKFG AATASIMHGL
     KWTGVWIVVG VIVIGIFFLI FLFK
//

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