(data stored in ACNUC9543 zone)

SWISSPROT: C0H4T3_PLAF7

ID   C0H4T3_PLAF7            Unreviewed;      5800 AA.
AC   C0H4T3;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 53.
DE   SubName: Full=Peptidase family C50, putative {ECO:0000313|EMBL:CAX64109.1};
DE            EC=3.4.22.49 {ECO:0000313|EMBL:CAX64109.1};
GN   ORFNames=PF3D7_0809600 {ECO:0000313|EMBL:CAX64109.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64109.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL844507; CAX64109.1; -; Genomic_DNA.
DR   RefSeq; XP_002808832.1; XM_002808786.1.
DR   SMR; C0H4T3; -.
DR   MEROPS; C50.001; -.
DR   PRIDE; C0H4T3; -.
DR   EnsemblProtists; CAX64109; CAX64109; PF3D7_0809600.
DR   GeneDB; PF3D7_0809600.1:pep; -.
DR   GeneID; 2655237; -.
DR   KEGG; pfa:PF3D7_0809600; -.
DR   EuPathDB; PlasmoDB:PF3D7_0809600; -.
DR   HOGENOM; HOG000280978; -.
DR   InParanoid; C0H4T3; -.
DR   OMA; HINILLF; -.
DR   Reactome; R-PFA-2467813; Separation of Sister Chromatids.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:InterPro.
DR   InterPro; IPR005314; Peptidase_C50.
DR   InterPro; IPR030397; SEPARIN_core_dom.
DR   PANTHER; PTHR12792; PTHR12792; 3.
DR   PROSITE; PS51700; SEPARIN; 1.
PE   4: Predicted;
DR   PRODOM; C0H4T3.
DR   SWISS-2DPAGE; C0H4T3.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Hydrolase {ECO:0000313|EMBL:CAX64109.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     90    108       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    352    377       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1701   1720       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1726   1742       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     5341   5433       Peptidase C50. {ECO:0000259|PROSITE:
FT                                PS51700}.
FT   COILED      201    221       {ECO:0000256|SAM:Coils}.
FT   COILED     1494   1514       {ECO:0000256|SAM:Coils}.
FT   COILED     2776   2803       {ECO:0000256|SAM:Coils}.
FT   COILED     3791   3825       {ECO:0000256|SAM:Coils}.
FT   COILED     4657   4680       {ECO:0000256|SAM:Coils}.
FT   COILED     5458   5478       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5800 AA;  698191 MW;  D99CFA66D0CAFD8B CRC64;
     MVRSNLNVYD KLDRIVSDVL QNIDEEYKNG GSDEKVYIKF YELFHKESYI EKLNYNDLIN
     TFKDKNIHKY LFYMFECVLN KISLKNNMKY LDFLFIILRY ITYFWFYLSE DNKLILISYY
     YSKLIDLLYN LKLKKSALLI NMYNILIYFY IKDKKKVIFE IKKIKENDAS THIKNLILEL
     NKILIYEQVK LITKITKEYY IDCLNEDIEK KLSKLILAEE DMNNFIKECN LYNYMWVCDE
     KIRYNNNDKC NNDKCNNDKS NNDICNNNIC NNNIYNNDKC NSNVYNNKIQ TNVTKKKKKE
     ENYFSFFIKY KNKNDIEMFI NCHPFSINSS YKIFLNFLKN FFKIIIDDFD TFFFFLSLFY
     LEYFLIYCHF FEIIYFIHLS NHEKNYNNVD TNNINVNSLD TNNINVNSLD TNNINLNSLD
     TNNINLNNID MNNMCDLQKK YNSKNIYKDT KFTSVNVSAN NVATTYDECI FLNNNKQNKR
     IIWNIIFDAL RKKFISDVKN VNYVLKIFKY TFSFFSFQKN LYLKRDNRTY IDNYIHNTLY
     NFRYISSIYL KELLKFCLSF ITNILYSKHL TEEIIFKSIS YIFHLLSKLL CNTNNDIKEF
     ILCDTDNNIV LISIITHIYK YFKKLYFSKN NEEVEISKSN NSKNNNVGVE KLKYSFITQD
     KVYQKIQECL YIVLTIDEHV ECYTRECIIP KNIDKENSHK NYNNYSYDNK NNVNVGNNPC
     DNPKNNFTDN FYICVIIKMN KMNMFYSNMD IIKVISEKDK NVFRKFIYTI NKNHENFINF
     FSYILNINYK GNEDDFILKK YILNLKRKNE YYNKDKKLIN VMKPYHSPLK YIFLKNEIQQ
     KGNMYNDSYD NYCNGVSSSE EISDEKKVKK KKTNKKDNNI NNINNNNNNN NNNNNNISNG
     YDKSYHYNFY NHDMSWNDNN YDNIHFDDKN EKKRDDMPIF ENSRFYINTK IMKNINVDFK
     NVCHTIILCV KRCIQISDNI FNHFEKNKNL EANFNIYVCK NILINFLKCC LLNISLSSYL
     CVKLNYDYIL KEICESNLVE YVYNIYDKYV CFILNQNVKS LNDHKHLLQF NIRNENKRRS
     NVDNKKIHNN NNNNNNNSNN SNICSSGVVK ESSLYNNLCL DDIYDILRNK KDTHENSNNN
     QDDITHPNNN YKNANDSNDY YDCQYSTFFI SDNTPFVETL YSNCFLIMIN VLLIWEMYLE
     IPLEILNKMR YSFFELFYNT TIKILKFIKT DKGFLFLLNI LKFIYTKFIS LPFNPIDIHT
     NFKMYDFYEF LISNKHDSNI NNHLNNNTPH HHHNNTYYYG CLDMEKKEDD KFNQDSLFMN
     SVSPLKFVHN NNEEEYNEEK SKNDSTNNII KHKHTNEKFN EYCNYNMLSV NKKKRISIGG
     LVPIFLTSQN RNEKKSKRKT MVDYVSYNKM ENDSFTDDAN IREKKKRNTL TYDESSFVNH
     IDNDHKVNYD FYNKNDNETP KNNYDNNKDM LSSENIKERK DDNEDDNEDD NDNNDNNNNN
     NNNNNNNNNN MKNKMRNTYL KNYYIPHIDL LFIIIDLEVY YYYGKKKYKK VIFIVETVFR
     NIINRCDYNT KEYLRSSISF IYNYYQQIHI KSNKNNIQSC GIIRHICNLY FKSKIFYLNK
     KIKKMLSYYK EKCSNIDSLK LNYNEMYDVF FNSLKWKYFF YFKKNVNSEN FYDNEKYKNY
     DNCDHFNNNI LLEVKQMESM ILIDELLSIH INILLFLILY EYICKYTNIH FVFYFRFIYL
     FFNKVCIDIL NIINCFNHVE FFNLFDFIYH NTYNDDINMY AVQKLKNALT KINEHKMLKN
     DIIHIPYKFN GSIEKINEKK SITYHHHHQK KKKIIIIDIE ELLVTYVQMN FIFCRICCIF
     LFFQNMCFHK YDLINKECKV KEYMKLFRSN RNIFDASRVK NDEDEYLKSE AINNNIDENN
     NMNIYNTSDY YETNKFGTNY LIPFDNKSSD YNKYDTDVSV SSISENSFIL DECSSYDSKK
     DYIILEFIIE KIEEINIALI YTNMLKNCYY IIKVEMLYNY IYNNIEILKR FAYLNNAYYL
     YKLYYNMFVW DNKNHFDGLK DINKKEKQKY MNGYNKDDMD GMSLKGYSNN YTKNNDIDDT
     SQNNDIDKTS QNNDIDDTSQ NNDIDDTSQN NDIDDTSQNN DIDDTSKNND IDDTSQDNDK
     TVSPKNNINN KYHKCYHIFH ILTLNQRLKE KMNARYIKLK FYDNSDLFTT YNDDIVKNQN
     DSYERTNENI MKNNNTCDDC FCKSSFDISY FSCNIYNFNL NLFHPLNIRK NRKIQIYENN
     TNRNPFISSQ VINNKYLMNL NKKYNKIKKY IMNYIISTYF IILCFYFNEY NIEEHNLSFY
     FILHLFQTKF HVFNNNFFLN IENRYESLNE NMYSPKHVIT KENKSREKNF IYLQECKYKI
     YTEYELKNNI YLIFEILNNI YDVYYGNIFE NISVHNNIEI NIDLNFITYL SEIYNILFFY
     KMYKECVHIL LLCIMCTSKF FCLYIFNEKH VYKEETSLDF VDKGNVKSKI IHITKKRNTH
     INMNAENNTH LNSNKVRYDY YYNDFMYEEK DKESKNIIKG SQECAEVKRI VYQDENVLEN
     NNMNEREFYA FEKVNMPFYD INSKNDNNDN NNNNNNKSKS KCKSKKEKTN IYNIKKNRII
     HILNIIYNKI TYNVNDMNVK EIYINLHNYM QNLIICISLF YSIYICLEKL CKKEYNIIFF
     NCANNIYNYY IEFYQYIKNF CKTYCKEKIY MSTFFFDNFN LKIINLRILS IIKEKEIYIK
     RKEKNISKRM NNDEIINNNK KKKKNHNNNN KNHNNNNNDN NNNNNKDPVS KVCLPNILPE
     NMSFSYIKEQ NDQSNNSNED SHILLFRTNF YSKFSYLLFD MRGNVFKDCM IMLRNIESRY
     KNDCNFIFRN NLELYFNIVK YLYENSKDQY IGLFLFFHGY IIYELEDKKI NMMKNFCSFN
     ISCNFFCLKF EQRSYDFDIE GLSNLSKNDS IDDIKLRNKL ILMNTENLYC NGFLRTDFFS
     VTKFFNIYIK NIYKIFFKLN NFFSSYFFLK EFIIYISSIL YLPEMVHIYI YLINIILTSG
     KERIEILTQE ELFFENLNNE FNMFEKKKFD QINKYDVYNK DVKIYEQNDF TDINYDKTPL
     NTYITNKYIY EYKKVLNEFF VYLNYLISNK QNMNILTPKY RKEILYIYSL FILKKKQKQY
     YYYVMKNRKW KTTNMFIDNL QNINHLEGED KNINGDNIKT TNVLHNTIHT KNISEDNNKK
     ERSNIISPVV NYEFNDDNNN NIENDELYNS NMDDINKFGK KFLQCFNECN KIRKNENICF
     QFFVENLFLG HNMDTDIYNI YINDEVSVTT ILKNMIFDDI SKININEKMN NMDIDYIKED
     DEAHIKNTHN SIYNNIYNNI YNNMRDTNNC NDHITYEKEK NNSTHFDNPY YDKNNKFNIY
     NLFNDIYYFN EDDIELNSSD FKLMDISVLN YLHLNYDFEN NLKYIYNYIN NRLFVYNCKK
     MNSYFIKILY YYINLVFLKI KNIFCDDCIY VIKKQQSLNS SANDCCSNIF FLLYVRLLYN
     LKIPKDILHE ICSNYFPGNK CKKYIDLLWN KQKFGNVPNN ECDYNKIKMV VQKGGMNKTE
     KSPQEYDTHN NDNNNNNNIN NNEDCGNSCN TGDNNFNCKN RCQPNPDILF LYLVEIFLFP
     DKDCSYFEVL STCYQFIINI KGGRENVYMK DEMLKRMYEI LKNILLKQNY ENIYYFQIIL
     IYTSLLLYNT HMKSLVYEMR IIAQFYLDFI FFFIENIKNN LIILDIIKSY AADQKDMCDM
     EKNNNIMSDQ KEEEKKKINN NDNNNKNENN NKNESNNTNE NNNDNNCNNF YNDEQNIFFY
     LLKCYFRKMI SLLYLYTDEL ILYTIKHNID FEINEREYFR KNVCTSINSD IIYKYMNVKE
     VNLSNLCIYW DYTIISVSQD KNSLYISRCY KNFLLILAQM FKIYHENELI NRIFSTDFYN
     MDIVNDINEL SFIINNQDQN IYNNIKNNIN NNINNNNNNT ISSSSSISSS ISSSSMNNNI
     DSNCNKLKSY CNLFNILNNN DLLEKHFDSM FDTYVIKSNI REWLNDNLYY STKDIEMNKQ
     GYTHEKNSTC NYNNVLNKHN INEIKNGEYI ACPENCDILK SDEKSLFISQ LNHYKKENFF
     YNFNIYDVVN VDKEIDMKEQ RHVNNSNNII NNVNVVHLFI LLNKRANECL NRKRVEYFHV
     EKIHLNIERY TYKNKWNYIR KLEKFLKQYQ HMIKVMCEIL SESKYVDRNE INLRKCVDQW
     WKNRYLLEQH LKILNLDISN SLGFSIHKLM SIPLINIITK WNIMDDKSMK NYTAEDDNNN
     ENYNNIENYN DNENNYYCDV LEDEKKNIST LNHSKNDEEN YVHNTISPLN NQLYYLKANF
     DIFIYIFYFH QILRILRWLR KWNKFILPLK YWSEIDYINV LINLTIFSVT LKNCNLEIIN
     VKKKYLQKMC NLKKRRDDKN VSKDYFCKEE IIIQNGNKND DINNVNKNKT NYYNYNDNHN
     MKQKNIDFSN DILSKNEIQH SDYIIDQYNI SYYENFINEH NINKKDNIII KNNRNSLNIN
     KTSTSYLPCY NKDIEDILIF KKMIEKKKEK EPTDTKKGKI RGRRHTYCEQ NIYSVEEYGE
     NNIYLRPNMN PTIKNDVVKN NTNNSKYTNC NIPINSINSC NNNIENYDEL EEKKKKKKNS
     SSITSNTKMN IKKKTDNFNN NNVYEYLNPL KNTNNSECEI NENYKLVNKK KNNKRNTISG
     IFFDYDMKQR YEELPEKNFL KFLDLRKKCV KGLLRCSFIK LRMYLYHILI DVFENADIDP
     MNIFDLFNII THSFIKDVLF CNLTIDKTNK DKYIYTRNVE NNSVRKNPVI LYVHSNLSRI
     SLENLEPLKD SYIVRGVSKM VTTYLYKRLV NKIKRGKSIG KKKKYIYDNK HDEDEYNNND
     EDDYNNNDED EYNNNDEDDY NNNDEDEYNN NDEDEYNNNN NEDNYNNNVD DMDMKKYINY
     EYNKKWEIDS SENVCDKKNV ARRATYNSTT LKDINKNINN NNNNNDSKIV TKNGIMKDNP
     NGNYNIFNFY DNKNSFNKNQ GKTFDNSINM KRKNEKEEYV IIDDDDTNNN NNNNNNNNLL
     NNKKGDNNYN LIVTKEEEKN PMYSNKSNNT KEKKNHKRSR KSMNIEYSFI NPFLNKYKER
     SKNKRNFTSC STQFLSDKGE EEKKRKDEYN MSEKEYILDR NKKKKTIKNN KSIISSNISI
     TRSLSNSSDS SVELVQNEDE LKKIFMNVRN SLNFQNIMSI DNKEEYCDYL YSKRKNSISE
     SEAYFGEKKM KRMSSFLKTS KKDKRRTYSN EREYGSKTYE VNGIKYVPYY ISSPRIIDPY
     KSKIFFLINP NGDLKRTEDA IIPFIYHKNK EKYKYKNWDG YIGNVPNENI LIDHLCNDDL
     FLYCGHQGAE QYMKKENIKN GLPSLEFIID YIVEKKIINL KKYPKIKEVI NLYTNKYNNK
     KNQQVENSSN AKQNINQRKR NSSTFTLTKN EKNTRNFIKK DMKRKNIGSI NNILVHLENI
     KRKNTTKNKD NISDDNNVDG NNMDNDNNNN NNNSKIYISP LSKGLNCCTF LIGCSSGLIS
     SYGFDLDAWG TVYDYIVGGS LFVFGNLWNV TDGEVDGFTQ NFLWKWTQPN SSSLFQAKFI
     YNEKLPSLNL SFSFFLELFL KNMKNNQNIK NYQNIKNNQN IKNNQNIKNY QNIKNYQNIK
     NIEKLFNNNI NLLKLDMDIG DNFITVPMNI YKFIIKNKFF YIYFTDYYNT NIFVNKNLYY
     INQNKKYMWL SITEALTEAK QYCRLPYGTG SAGVMYGLPI
//

If you have problems or comments...

PBIL Back to PBIL home page