(data stored in ACNUC9543 zone)

SWISSPROT: C0H4T6_PLAF7

ID   C0H4T6_PLAF7            Unreviewed;       550 AA.
AC   C0H4T6;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   11-DEC-2019, entry version 78.
DE   SubName: Full=Protein phosphatase PPM5, putative {ECO:0000313|EMBL:CAX64112.1};
DE            EC=3.1.3.16 {ECO:0000313|EMBL:CAX64112.1};
GN   ORFNames=PF3D7_0810300 {ECO:0000313|EMBL:CAX64112.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64112.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA   Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA   Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA   Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA   Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA   Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA   Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA   Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA   Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA   Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA   Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|SAAS:SAAS00882743};
CC   -!- SIMILARITY: Belongs to the PP2C family.
CC       {ECO:0000256|RuleBase:RU003465}.
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DR   EMBL; AL844507; CAX64112.1; -; Genomic_DNA.
DR   RefSeq; XP_002808835.1; XM_002808789.1.
DR   PRIDE; C0H4T6; -.
DR   EnsemblProtists; CAX64112; CAX64112; PF3D7_0810300.
DR   GeneDB; PF3D7_0810300.1:pep; -.
DR   GeneID; 2655471; -.
DR   KEGG; pfa:PF3D7_0810300; -.
DR   EuPathDB; PlasmoDB:PF3D7_0810300; -.
DR   HOGENOM; HOG000280973; -.
DR   InParanoid; C0H4T6; -.
DR   OMA; KELPYMI; -.
DR   Reactome; R-PFA-1169408; ISG15 antiviral mechanism.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004724; F:magnesium-dependent protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004722; F:protein serine/threonine phosphatase activity; IBA:GO_Central.
DR   CDD; cd00143; PP2Cc; 1.
DR   InterPro; IPR015655; PP2C.
DR   InterPro; IPR000222; PP2C_BS.
DR   InterPro; IPR036457; PPM-type_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase_dom.
DR   PANTHER; PTHR13832; PTHR13832; 2.
DR   Pfam; PF00481; PP2C; 1.
DR   SMART; SM00332; PP2Cc; 1.
DR   SUPFAM; SSF81606; SSF81606; 1.
DR   PROSITE; PS01032; PPM_1; 1.
DR   PROSITE; PS51746; PPM_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0H4T6.
DR   SWISS-2DPAGE; C0H4T6.
KW   Hydrolase {ECO:0000256|RuleBase:RU003465, ECO:0000256|SAAS:SAAS00927111,
KW   ECO:0000313|EMBL:CAX64112.1}; Magnesium {ECO:0000256|SAAS:SAAS00882703};
KW   Metal-binding {ECO:0000256|SAAS:SAAS00882779};
KW   Protein phosphatase {ECO:0000256|RuleBase:RU003465,
KW   ECO:0000256|SAAS:SAAS00927143};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN          131..542
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51746"
FT   REGION          48..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..349
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..304
FT                   /note="Acidic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..332
FT                   /note="Polyampholyte"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..349
FT                   /note="Basic"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   550 AA;  63620 MW;  1CFEB6E7EEB7BEA0 CRC64;
     MGTCISFLKK NSVKEKKNTR RRLSISTKID LPDDTEEIKR SIQELKHNED KFKESSENVT
     TRRISENEVQ EVVEGEENEE EEERRKKLDK KKRSLKNRSS VAGVRASHFQ EDFEKKCVKI
     KGSVEKLHEN GIGYVCRKGL KPESPNQDDF IIITMENLAL YAIFDGHGPY GHDVSNYVQK
     ELPYMIIKNE NFLKNPKEVF TKAFLNIHEN IERTTNAYLD SFTNKNSNNK LHLNSNFVIN
     DQALESMQGY NNYTDSDTNS DDSYDYDDTI EDDEDDEEDD EEDESNDNKD DDHEEEEEEG
     ESNSSIDDEF NKENKKTKKE NDPDVKEEKS LTTRKKKQKK KKMKKRKKRK NKIFFDSTMS
     GTTATIIVHL FKEKKLYVAY VGDSRAVLGK RKNGSKQLSA VELTKDHKPN CAAEKKRILS
     SGGQVMKLEG DIPYRVFIKN KFYPGLAMSR AIGDTIGHQI GIIAEPDFIE VNINEDEDIL
     VLICSDGVWE FISSEEAVNL IYEFGYNNVQ DAVENLARES WDRWLNEEEN IVDDITIQAI
     YLSEKSKYLK
//

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