(data stored in ACNUC9543 zone)

SWISSPROT: C0H4T7_PLAF7

ID   C0H4T7_PLAF7            Unreviewed;       603 AA.
AC   C0H4T7;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 63.
DE   SubName: Full=Aquaporin, putative {ECO:0000313|EMBL:CAX64113.1};
GN   ORFNames=PF3D7_0810400 {ECO:0000313|EMBL:CAX64113.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64113.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC       {ECO:0000256|SAAS:SAAS01163906}.
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DR   EMBL; AL844507; CAX64113.1; -; Genomic_DNA.
DR   RefSeq; XP_002808836.1; XM_002808790.1.
DR   EnsemblProtists; CAX64113; CAX64113; PF3D7_0810400.
DR   GeneDB; PF3D7_0810400.1:pep; -.
DR   GeneID; 2655296; -.
DR   KEGG; pfa:PF3D7_0810400; -.
DR   EuPathDB; PlasmoDB:PF3D7_0810400; -.
DR   HOGENOM; HOG000280972; -.
DR   InParanoid; C0H4T7; -.
DR   OMA; ILGAHIN; -.
DR   Reactome; R-PFA-1237044; Erythrocytes take up carbon dioxide and release oxygen.
DR   Reactome; R-PFA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR   Reactome; R-PFA-432047; Passive transport by Aquaporins.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015267; F:channel activity; IEA:InterPro.
DR   Gene3D; 1.20.1080.10; -; 1.
DR   InterPro; IPR023271; Aquaporin-like.
DR   InterPro; IPR034294; Aquaporin_transptr.
DR   InterPro; IPR000425; MIP.
DR   PANTHER; PTHR19139; PTHR19139; 1.
DR   Pfam; PF00230; MIP; 1.
DR   SUPFAM; SSF81338; SSF81338; 1.
PE   3: Inferred from homology;
DR   PRODOM; C0H4T7.
DR   SWISS-2DPAGE; C0H4T7.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Membrane {ECO:0000256|SAAS:SAAS01163903, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01163912,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01163910,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     48     68       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    284    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    330    352       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    384       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    452    473       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    499    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    526    543       Helical. {ECO:0000256|SAM:Phobius}.
FT   COILED      125    145       {ECO:0000256|SAM:Coils}.
FT   COILED      192    221       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   603 AA;  71625 MW;  BD97A32E7BE231E2 CRC64;
     MKIQKGLFFL QRSIKNVLRK IIKFIKGYVK DIIKEINVKS LKKYKYNLFF EFIGSFLFVF
     FISIYMLNSN SNEEYIIKHT KQINPYKTND ILIPGHNNFE AEINNIKYMN NLNQERKNVV
     ASILLEKYDN EYKGNNKSKR EVERDDDKIS NNLQNEFEKD NEKKKNYDNI NEKEISTTSD
     GKIKDMEDPK NISNKNENYD NTNMELKNEK INNKVNDEKN IKNEDDINNK ENMLKSVDKI
     IFKEPVNEYS KIKIEDINNI NLKDIDQYEV LKNSENKKSS NHAIYSFVGC FIYVIFILLG
     AHINPAYTYA LWLTEPKKYG FALSTLYITF QYFGGIVASI ICAHLYGSIF IYTLLPKKEI
     IKTFLCEFIS TFLITLLLLS LYNYKKKFME ENKNDESLTF NINKLRNMSS LYNFNTYEDF
     YSYDMFSTNQ NRKYNSFLYI DNKYIKYIMN HIFYLLFIFF SLLFFVFVTN TTLNPMFSTS
     TLYTYLYYKI FKASNSFKIY SIFISFLSIT KIFQLLIFYI QSLPLWIGPY FGSAFAATFL
     SLFKENEEEI INIIDTNVYS SYNKKKEQIP LIDKNSAKQN AYLIEYNDNI HNNSYNYLLP
     SVF
//

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