(data stored in ACNUC9543 zone)

SWISSPROT: HEPF1_PLAF7

ID   HEPF1_PLAF7             Reviewed;        2082 AA.
AC   C0H4W3;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   RecName: Full=Probable ATP-dependent helicase PF08_0048;
DE            EC=3.6.4.-;
GN   ORFNames=PF08_0048;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T.,
RA   James K.D., Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A.,
RA   Kyes S., Chan M.-S., Nene V., Shallom S.J., Suh B., Peterson J.,
RA   Angiuoli S., Pertea M., Allen J., Selengut J., Haft D., Mather M.W.,
RA   Vaidya A.B., Martin D.M.A., Fairlamb A.H., Fraunholz M.J., Roos D.S.,
RA   Ralph S.A., McFadden G.I., Cummings L.M., Subramanian G.M.,
RA   Mungall C., Venter J.C., Carucci D.J., Hoffman S.L., Newbold C.,
RA   Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7;
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
RN   [3] {ECO:0000305}
RP   SYNTHESIS OF 284-312, AND POSSIBLE CANDIDATE MALARIA EPITOPE.
RX   PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA   Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA   Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA   Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT   "Rapid identification of malaria vaccine candidates based on alpha-
RT   helical coiled coil protein motif.";
RL   PLoS ONE 2:E645-E645(2007).
CC   -!- FUNCTION: Catalytic component of a chromatin remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of a chromatin-remodeling complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
CC       ProRule:PRU00549}.
CC   -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine
CC       as determined by epitope response in sera.
CC       {ECO:0000269|PubMed:17653272}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. SWR1
CC       subfamily. {ECO:0000255}.
DR   EMBL; AL844507; CAX64141.1; -; Genomic_DNA.
DR   RefSeq; XP_002808863.1; XM_002808817.1.
DR   SMR; C0H4W3; -.
DR   BioGrid; 1210343; 7.
DR   PRIDE; C0H4W3; -.
DR   EnsemblProtists; CAX64141; CAX64141; PF3D7_0820000.
DR   GeneDB; PF3D7_0820000.1:pep; -.
DR   GeneID; 2655499; -.
DR   KEGG; pfa:PF3D7_0820000; -.
DR   EuPathDB; PlasmoDB:PF3D7_0820000; -.
DR   InParanoid; C0H4W3; -.
DR   OMA; TSYCFNF; -.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; NAS:UniProtKB.
DR   GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR   GO; GO:0000812; C:Swr1 complex; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; ISS:GeneDB.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; ISS:GeneDB.
DR   GO; GO:0016887; F:ATPase activity; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0043044; P:ATP-dependent chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0016458; P:gene silencing; IBA:GO_Central.
DR   GO; GO:0043486; P:histone exchange; IBA:GO_Central.
DR   CDD; cd00079; HELICc; 1.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR014012; HSA_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07529; HSA; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 3.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51204; HSA; 1.
PE   1: Evidence at protein level;
DR   PRODOM; C0H4W3.
DR   SWISS-2DPAGE; C0H4W3.
KW   ATP-binding; Chromatin regulator; Coiled coil; Complete proteome;
KW   DNA-binding; Helicase; Hydrolase; Merozoite; Nucleotide-binding;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN         1   2082       Probable ATP-dependent helicase
FT                                PF08_0048.
FT                                /FTId=PRO_0000388752.
FT   DOMAIN       66    138       HSA. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00549}.
FT   DOMAIN      674    839       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN     1772   1922       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     687    694       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED      476    531       {ECO:0000255}.
FT   COILED     1972   2060       {ECO:0000255}.
FT   MOTIF       790    793       DEAH box. {ECO:0000255}.
FT   COMPBIAS     36    187       Lys-rich. {ECO:0000255}.
FT   COMPBIAS   1025   1366       Asn-rich. {ECO:0000255}.
SQ   SEQUENCE   2082 AA;  246748 MW;  253B2FB6DDCFD602 CRC64;
     MNEIKSESLL QTRPFKLGIE DIQNLGSSYF IENNEKLKKY NNEISSLKKE LDILNEKMGK
     CTTTTKIVEP AKTPEFTFWY YELKEMKGFQ DLVMYEVKKK KKHFKVLSHS CLKYLSNREK
     MKIKKQEEEE KRLKLYSKNI SSYMDVFWKK IEKLVWEEKK RELQQTLNKK KEMRFKKFVK
     EAIKKIKDAR HNNAHELFEN KYVSMSSNNN SEIVNNNASS VDNGDKELKE DDLTDQEEED
     YLLDEQMSST DESENKEEEI NMLDDEANLP IEELLKRMYG FKSGEDYINF MENEDDANEE
     NVIETSHNDE KSGDNSIGED DNNNDEKGGD NNIDEDDNNN DEKSGDNSIG EDDNNNDHKS
     GDNNIDEDDN NNDHKSEDNS IGEDDNNNDE KGGDNNIDEN DNNSDHKSED NNIDENDNNS
     DHQSDQEQFN HETKDDIIKN SSYEHIDNKN YYNKTGEDYK SDKENYSPTR FHNKLKKEKY
     DEYDTKLKIE KREEENKNYE KDEHEYESDN YDKEKINKKK ELILLKNDIE NDSDETSEHI
     KRDSRSSCQK QNCEKKRRII KDEYNLRRTK IAKSKPSSDN NNSENDNNND NNNDNNNDNN
     DDNNDDNNDD NNDDNNDDNN DDNNDDNNNE HKNDSDDNDD ILTCNMDEKH LTKIPPIIKA
     TLRDYQHAGL HWLLYLYKNN INGILADEMG LGKTLQCISL LSYLAYYFNI WGPHLVIVPT
     SILINWEIEL KRFCPCFKIL SYYGNQNERY KKRVGWFNKD SFHICISSYS TVVKDHLVFK
     RKRWKYIILD EAHNIKNFNT KRWNIILSLK RDNCLLITGT PLQNSLEELW SLLHFLMPNI
     FTSHLDFKEW FSDPLNLAIE KSKIHHSKEL IDRLHTVIRP YILRRLKKNV EKEMPNKYEH
     IIKCKLTRRQ QILYDEFINN KNVQNTLNTG NYIGLMNILI QLRKVCNHCD LFTNKYIQTP
     YYYMLSIRYF VPRFFILFEK NYYADFYLIL FLHNEFTSLG GRDVTKETSP SSKSFDLAHI
     LTKHNTNELY DNNHISELYD NNHISELYDN NHISELYDNN HISELYDNPM SHKNYKHNSN
     GYTYPNDPIN NMNNNPSGFT KTSEQFGQIV SHERDNNYHM MDHNNMNNLL SKEMVNSLRN
     DDNSNNNFYK YSLTSNNNDS QTSIHDNKQC DYNKLCADTF NNINSIGNEE KRSLNVLNEQ
     NNNNSKDNNN NIDNNNNIDN NNNIDNNNNI DNNNNIDNNN NNIDNNNNID NHHNNNQHCN
     YNDNWPSDYP TNIINHRNAF LSILKLLNQS NPLNNDNNNN NNNNNGNNNI YNMNRYNSRN
     SRNSSLSNIF SSNTSKMNSF QLDFLYTNSF INQDALCKNS FFVNINIEDV HSYIYNSIYK
     EYIPKNILSF SDEFLTELNN NYDILSLYID PYNRYKSYNE YLYKMKEEGT LTNQQSLGDI
     NNKHIYHKST SNENTHMKNR KTFIYKYNNM FKVINNDTQY QNIFTDDTNN SYYNSLEHNL
     WIKRNQIDER KKEEEEEQNK YYNVCMNNLY ILRNERIPIF GKNFLDLIKK EFTKDKNIVY
     NYTNNVPIDY YSSVKEVWVE DICEKDNKKR KCKREKRWYK KIKKTNNPPE DSEVYRENSS
     DVEKYNCDVE KDNCDDEEKD NCDDEDMNSN LSSNVYGCID ISSQNFIHSR YHNPMMNMSY
     IIEFLFPNME QFLKRHEKMI HNFTLINNPS VICKSHDIRI NNNLLNYSND KMNPIILQIK
     NATRVYHDAF LKQSIIFPLN KDISLGSGKL CALEKLLSKC KREGNKCLLF TQFIKMLDIL
     EIFLNHLNYS FIRLDGSTKV EQRQKIVTKF NNDKSIFIFI SSTRSGSIGI NLTAANVVIF
     YDTDWNPSID KQAMDRCHRI GQTKDVHVFR FVCEYTVEEN IWKKQLQKRK LDNICINMGN
     FNNSNTHSKI TDTDPTHNKD WFTNVDTIKE VFINKKNNDD DDDMYKDRLL HEQVENKDKM
     NVRFEKTLEH VEDKDDIRAL NETKKETQNE ISQNMQEFTT RNDFQDSYNL TSYCFNFLNE
     NLTDSLKQQI DEMRMKIEIE MMNTGDENMS LSDLSNKSHN SE
//

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