(data stored in ACNUC9543 zone)

SWISSPROT: C0H4Y0_PLAF7

ID   C0H4Y0_PLAF7            Unreviewed;      1326 AA.
AC   C0H4Y0;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 65.
DE   SubName: Full=Ubiquitin conjugation factor E4 B, putative {ECO:0000313|EMBL:CAX64158.1};
GN   ORFNames=PF3D7_0826500 {ECO:0000313|EMBL:CAX64158.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64158.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
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DR   EMBL; AL844507; CAX64158.1; -; Genomic_DNA.
DR   RefSeq; XP_002808880.1; XM_002808834.1.
DR   SMR; C0H4Y0; -.
DR   PRIDE; C0H4Y0; -.
DR   EnsemblProtists; CAX64158; CAX64158; PF3D7_0826500.
DR   GeneDB; PF3D7_0826500.1:pep; -.
DR   GeneID; 2655469; -.
DR   KEGG; pfa:PF3D7_0826500; -.
DR   EuPathDB; PlasmoDB:PF3D7_0826500; -.
DR   HOGENOM; HOG000282594; -.
DR   InParanoid; C0H4Y0; -.
DR   OMA; NKEEIAM; -.
DR   BioCyc; PLASMO:PF08_0020-MONOMER; -.
DR   Reactome; R-PFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0034450; F:ubiquitin-ubiquitin ligase activity; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR019474; Ub_conjug_fac_E4_core.
DR   InterPro; IPR003613; Ubox_domain.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF04564; U-box; 1.
DR   Pfam; PF10408; Ufd2P_core; 1.
DR   SMART; SM00504; Ubox; 1.
DR   PROSITE; PS51698; U_BOX; 1.
PE   4: Predicted;
DR   PRODOM; C0H4Y0.
DR   SWISS-2DPAGE; C0H4Y0.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450}.
FT   DOMAIN     1213   1291       U-box. {ECO:0000259|PROSITE:PS51698}.
FT   COILED      948    972       {ECO:0000256|SAM:Coils}.
FT   COILED     1270   1301       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1326 AA;  154634 MW;  56FB6E4F9CD63900 CRC64;
     MVDKIKEDAI IQNTFQICLK KEECNNNKLY LESYVKELKE NNEELYFLLD NLYFILLHKI
     SDLHRQKKNC LSYLCSCASR LVDKSLYKGI NMNNKESDII INEISDQIVN SVIIYLENLD
     IYPNMKISKK ERMEVFYEFL KKSCTSRFLK KLLSFIEEND KNEDDENSKQ LNKFFNPIID
     LILSNLNNRN LVYPKNDVAV LFSFLTGFKP IADLITHNKS MFLYINVNDR MKDNMNCDIK
     KESDKNLLST CKSMPVNTTD SSTNNITTNR SNNSNGNNDV PQEGPTTTNS NNNNANNNLS
     NNNLSSNNLS NNNLSSNSII RRSVPYAHFH STIIQNSYSR FSRDKEISTC GYNFQLNSLL
     GRLISPTIIN MPNILKKEEI AMYKYFFNSN TNSLNKMTLN GLKNTYTLLR KDTDWILENC
     VEIIKNLLKS SSDSKKIILL WINCILISNE KKTKIMYHYS TYPQSLDTSY GLFLKLLGEN
     SYGFCLNMFW VLLCLCEPIT VNKINDLDFF FFLRNDPFSK FLLKNITNQS SFEDKSNVEK
     IKKNVERSEC FQKEPKFITC IFWMTFKSLS VFFKPAVDEF IKIVQEAGNA KDKDFYYMNI
     HAWKIFLYNT RFNQLLFKFL HLCMNYFLHV AYVYDINGNI NNSMKTCLNE HNNSLVHLVL
     KCCPPPNEKY YNNTKEGTTE GTNIVSHMRE NEKVERNEPI GENKRIENND GVVENNQMNE
     SGRNGSLDED LNRDEREGIN ISNESNNRVS LGINNNEENT PMVISPLDGS DDRLYASPHF
     SIIPTFFLSD IFEILYLLYE LDLFKSPNNE TLMNYLDIDL FLAFSIFTML SENHIKSIHL
     RCESAPKTFS FLYKLDNLKK VIEESELTKK YIIKSLTNVF IASQKGEYTE RMQTRVRIVE
     NFNSFFLNKT YVNQFTQLVI NNNNLFVHLI HLLLNDVSFL VEEVVSYLSE IKRREENNKK
     KKDSQQENEQ EANSNSYLNA TTRNNRTSNG SSNSVANLNY SSLNNNNNNN NNNNNNNNNN
     NNNNSNNFND SSFNSDNNSD DGEEGGMDYD LSNESMRNLA AKTKMIITYC YKSCIFLNLL
     CKNYPNNILT SNTILSQIVT CLNCYFDYLV GPKCLNIKVK NMEQYNFRPQ LWLTSIVESY
     LFLLNSDKEH EELLIREIAN EGRYYKAEIF NKAYYICKRE GLLHKEELNK FKNFCQEIVD
     MKDEVELFND VDDIPDNFLD PILQDIMLDP VLLPTSGIII DRKNIERHLM SEPNDPFNRA
     PLSKEQLVPM PQLKEEIQNY INKLRQEKKK KKKKIDNIDF DVENEEFPNF HQEQNGEVQK
     NETSNM
//

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