(data stored in ACNUC9543 zone)

SWISSPROT: C0H4Y6_PLAF7

ID   C0H4Y6_PLAF7            Unreviewed;       483 AA.
AC   C0H4Y6;
DT   05-MAY-2009, integrated into UniProtKB/TrEMBL.
DT   05-MAY-2009, sequence version 1.
DT   08-MAY-2019, entry version 90.
DE   RecName: Full=Protein disulfide-isomerase {ECO:0000256|RuleBase:RU361130};
DE            EC=5.3.4.1 {ECO:0000256|RuleBase:RU361130};
GN   ORFNames=PF3D7_0827900 {ECO:0000313|EMBL:CAX64161.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CAX64161.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
RN   [2] {ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368867; DOI=10.1038/nature01095;
RA   Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA   Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA   Buckee C.O., Burrows C., Cherevach I., Chillingworth C.,
RA   Chillingworth T., Christodoulou Z., Clark L., Clark R., Corton C.,
RA   Cronin A., Davies R.M., Davis P., Dear P., Dearden F., Doggett J.,
RA   Feltwell T., Goble A., Goodhead I., Gwilliam R., Hamlin N., Hance Z.,
RA   Harper D., Hauser H., Hornsby T., Holroyd S., Horrocks P.,
RA   Humphray S., Jagels K., James K.D., Johnson D., Kerhornou A.,
RA   Knights A., Konfortov B., Kyes S., Larke N., Lawson D., Lennard N.,
RA   Line A., Maddison M., Mclean J., Mooney P., Moule S., Murphy L.,
RA   Oliver K., Ormond D., Price C., Quail M.A., Rabbinowitsch E.,
RA   Rajandream M.A., Rutter S., Rutherford K.M., Sanders M., Simmonds M.,
RA   Seeger K., Sharp S., Smith R., Squares R., Squares S., Stevens K.,
RA   Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA   Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT   "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL   Nature 419:527-531(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.;
CC         EC=5.3.4.1; Evidence={ECO:0000256|RuleBase:RU361130};
CC   -!- SIMILARITY: Belongs to the protein disulfide isomerase family.
CC       {ECO:0000256|RuleBase:RU004208, ECO:0000256|SAAS:SAAS00569802}.
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DR   EMBL; AL844507; CAX64161.1; -; Genomic_DNA.
DR   RefSeq; XP_002808883.1; XM_002808837.1.
DR   SMR; C0H4Y6; -.
DR   DrugBank; DB11638; Artenimol.
DR   SwissPalm; C0H4Y6; -.
DR   PRIDE; C0H4Y6; -.
DR   EnsemblProtists; CAX64161; CAX64161; PF3D7_0827900.
DR   GeneDB; PF3D7_0827900.1:pep; -.
DR   GeneID; 2655362; -.
DR   KEGG; pfa:PF3D7_0827900; -.
DR   EuPathDB; PlasmoDB:PF3D7_0827900; -.
DR   HOGENOM; HOG000065811; -.
DR   InParanoid; C0H4Y6; -.
DR   KO; K01829; -.
DR   OMA; VAIVKMD; -.
DR   PhylomeDB; C0H4Y6; -.
DR   Reactome; R-PFA-3299685; Detoxification of Reactive Oxygen Species.
DR   Proteomes; UP000001450; Chromosome 8.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IDA:GeneDB.
DR   GO; GO:0020009; C:microneme; IDA:GeneDB.
DR   GO; GO:0003756; F:protein disulfide isomerase activity; IDA:GeneDB.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   GO; GO:0006457; P:protein folding; IDA:GeneDB.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IBA:GO_Central.
DR   InterPro; IPR005788; Disulphide_isomerase.
DR   InterPro; IPR005792; Prot_disulphide_isomerase.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 2.
DR   SUPFAM; SSF52833; SSF52833; 3.
DR   TIGRFAMs; TIGR01130; ER_PDI_fam; 1.
DR   TIGRFAMs; TIGR01126; pdi_dom; 2.
DR   PROSITE; PS00194; THIOREDOXIN_1; 2.
DR   PROSITE; PS51352; THIOREDOXIN_2; 2.
PE   3: Inferred from homology;
DR   PRODOM; C0H4Y6.
DR   SWISS-2DPAGE; C0H4Y6.
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR605792-51,
KW   ECO:0000256|SAAS:SAAS00903405};
KW   Isomerase {ECO:0000256|RuleBase:RU361130,
KW   ECO:0000313|EMBL:CAX64161.1};
KW   Redox-active center {ECO:0000256|PIRSR:PIRSR605792-51,
KW   ECO:0000256|SAAS:SAAS00903442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Repeat {ECO:0000256|SAAS:SAAS00038388};
KW   Signal {ECO:0000256|RuleBase:RU361130}.
FT   SIGNAL        1     24       {ECO:0000256|RuleBase:RU361130}.
FT   CHAIN        25    483       Protein disulfide-isomerase.
FT                                {ECO:0000256|RuleBase:RU361130}.
FT                                /FTId=PRO_5005124648.
FT   DOMAIN       23    138       Thioredoxin. {ECO:0000259|PROSITE:
FT                                PS51352}.
FT   DOMAIN      333    463       Thioredoxin. {ECO:0000259|PROSITE:
FT                                PS51352}.
FT   COILED      255    275       {ECO:0000256|SAM:Coils}.
FT   DISULFID     60     63       Redox-active. {ECO:0000256|PIRSR:
FT                                PIRSR605792-51}.
FT   DISULFID    384    387       Redox-active. {ECO:0000256|PIRSR:
FT                                PIRSR605792-51}.
SQ   SEQUENCE   483 AA;  55514 MW;  3DE86F4BCC20BAD6 CRC64;
     MNRKYFSSLF LFLISFVFES FVRSHGDLFN HFVTDIHDGE LDKFITKNDI VLVMFYAPWC
     GHCKRLIPEY NEAANMLNEK KSEIKLVSID ATSENALAQE YGITGYPTLI LFNKKNKINY
     GGGRTAQSIV DWLLQMTGPV FSHVEGNIED VLKEKKINVA FYLEYTSEDN DLYKKFNEVG
     DKNREIAKYF VKKNDKHNKL FCFRTDEKKV EYDEKTPLEE FVTSESFPLF GEINTENYRF
     YAESPKELVW VCATYEQYNE IKEHVRLAAQ ELRKKTHFVL LNIPEYAEHA KASLGLTEFP
     GLAFQSNEGR YLLKNPKESL LNHNAIINFF KDVEAGKIEK SLKSEPIPED DKNAPVKIVV
     GNSFVDVVLK SGKDVLIEIY APWCGHCKKL EPVYEDLGRK LKKYDSIIVA KMDGTLNETP
     IKDFEWSGFP TIFFVKAGSK IPLPYEGERS LKGFVDFLNK HATNTPISID GVPEFEDGTS
     EEL
//

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