(data stored in ACNUC16935 zone)

SWISSPROT: C8VLS7_EMENI

ID   C8VLS7_EMENI            Unreviewed;      1448 AA.
AC   C8VLS7;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   05-JUL-2017, entry version 55.
DE   SubName: Full=ABC multidrug transporter (Eurofung) {ECO:0000313|EMBL:CBF84719.1};
GN   ORFNames=ANIA_08892 {ECO:0000313|EMBL:CBF84719.1};
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321 {ECO:0000313|EMBL:CBF84719.1, ECO:0000313|Proteomes:UP000000560};
RN   [1] {ECO:0000313|Proteomes:UP000000560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.J., Wortman J.R.,
RA   Batzoglou S., Lee S.I., Basturkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M., Hynes M., Paoletti M., Fischer R., Miller B., Dyer P.,
RA   Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2] {ECO:0000313|Proteomes:UP000000560}
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCG
CC       family. PDR (TC 3.A.1.205) subfamily.
CC       {ECO:0000256|SAAS:SAAS00709344}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00434}.
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DR   EMBL; BN001307; CBF84719.1; -; Genomic_DNA.
DR   ProteinModelPortal; C8VLS7; -.
DR   STRING; 162425.CADANIAP00007977; -.
DR   EnsemblFungi; CADANIAT00007977; CADANIAP00007977; CADANIAG00007977.
DR   HOGENOM; HOG000162078; -.
DR   InParanoid; C8VLS7; -.
DR   OMA; FWKYTMY; -.
DR   OrthoDB; EOG092C1HKF; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
DR   CDD; cd03233; ABCG_PDR_domain1; 1.
DR   CDD; cd03232; ABCG_PDR_domain2; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR013525; ABC_2_trans.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR034001; ABCG_PDR_1.
DR   InterPro; IPR034003; ABCG_PDR_2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010929; PDR_CDR_ABC.
DR   Pfam; PF01061; ABC2_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF06422; PDR_CDR; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
DR   PRODOM; C8VLS7.
DR   SWISS-2DPAGE; C8VLS7.
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434,
KW   ECO:0000256|SAAS:SAAS00555301};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000560};
KW   Membrane {ECO:0000256|SAAS:SAAS00709359, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434,
KW   ECO:0000256|SAAS:SAAS00555311};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000560};
KW   Repeat {ECO:0000256|SAAS:SAAS00709352};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00709342,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00709353,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00709346}.
FT   TRANSMEM    555    588       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    594    615       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    627    647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1185   1206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1221   1251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1258   1276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1282   1304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1316   1335       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1413   1437       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      111    364       ABC transporter. {ECO:0000259|PROSITE:
FT                                PS50893}.
FT   DOMAIN      824   1059       ABC transporter. {ECO:0000259|PROSITE:
FT                                PS50893}.
FT   NP_BIND     857    864       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00434}.
SQ   SEQUENCE   1448 AA;  162058 MW;  CA28C5870194C2C5 CRC64;
     MPARLHSRPQ GNSTLASSQE AGDHADRPSS PQVHLTYEDE DAIAEIHRTL TKKDHDYSEP
     HLSFDKFLEE ELRAGRKKPN LGVCFQSLST WGTGGEHVNV KTLGTALWRT LIFQDVYEWT
     IKPWLAKPEP ESGRQLIRDF TGVVRSGEIM LVLGRPGSGC STFLRTIAGY HSSFLGVTGS
     IAYSGLSLED VRKHYRGQVA YVPEDDVHFP TLSVRQTLEF ALQSKTPKRY HDRIPRYLEI
     YGRVFGMSHT MDTLVGNEYI RGVSGGERKR ISIIESLATD SSVMCWDNST RGLDASSALD
     YARSLRIMTD TCGKATLMTL YQASDAIYDL VDKVLLIDEG RMLYQGPAHE AKAYFHDLGY
     ECGPMQTVSD FLTSITIPER RKFREGWEQR APKGPIELEQ AFRKSAAFMN VQKEVRSYDS
     QGFGGRSRAE SHSDTDYESL EDVKEALQTD KSRFVSSKSP YTISLFRQVV LCAKRQIWQI
     RGHMSPLYIK LISSVIYGLL VGSMFYDQPQ TTDGMYSRGG VIFYSSILLA WLQMSELEEA
     MQGRDILSRQ KKFAFVRPSA VCLARVVADI FIAALLTFLY LVVVYFLSGL KSDAGAFFID
     FLFIYMCTIS LTAQFRLFAA ASSNFEVALR YTGFLVLLCI VFGGYVLSVD KMMADVPWVG
     WIAYITPALY TYEAMMAAEF HNTNFTCSPA SVVPAGPVYT DIAYQTCAYA GSQIGSTIVN
     GDDYLAVKYG FYFSHVWRNF GILCLFTVAS VAATCLLSEI MEWEPDSAGP VQYKKSRKQL
     RKIANISDEE ERPVQVNQTS PSASDTDGPS VGALTATKST FTWDNLELFV RVGKENRKLL
     DGVSGYCKPG TLTALVGASG AGKSTLLTAL TQRQSSGDLT GTMYVDGRPI DSSFKSRIGY
     CEQMDIHDES STIREAFEFS ALLRQDSTVP DQEKLAYART VLETLDLVEL QNAIIGSLDI
     EKKKRVTIGV ELCARPELLL FLDEPTSGLD SQAASSICAL LRRLADQGLA ILCTIHQANQ
     EQFEMFDRVL ALSPGGKTYY FGEVGEAGHS IFDYFAKYGQ KPENITNAAD YIIEVVVGGM
     KNTASTVDWA AVWNQSVEAQ QVQQDLERFR NMKQESLPSL DMQSQAMPAI SRQIFLLTQR
     TSRQFWRSPE YPYSRLYASF LHALINCLTY LQIGNSTTDL QSKAFSCFLV LMLVPEFINA
     ISARFIMNRD LWKAREGPSG AYGWVAFCTA QIISEIPYAI ISAVVFFVLY YFSVGLPLGF
     AAGYSFLMFF LFFLFATSWG QWIAALSADS VVAATLMPFF IIMCETMNGI LQPHKYMPAF
     WAYTMYYVTP FTYWIGGVLT SVLRGVPVIC DENELTVFQS PPNITCSEYA GSWLAEKGVG
     YLSNPDGSGE CGYCEYSYGD DYLSTIGLDS SKIWPYFGIF VAFVVSNYLM VYLLVYIRSV
     MKPFRRRT
//

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