(data stored in ACNUC16935 zone)

SWISSPROT: VPS10_EMENI

ID   VPS10_EMENI             Reviewed;        1416 AA.
AC   Q5AS50; C8VLU2;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   05-JUL-2017, entry version 70.
DE   RecName: Full=Vacuolar protein sorting/targeting protein 10;
DE   AltName: Full=Carboxypeptidase Y receptor;
DE            Short=CPY receptor;
DE   AltName: Full=Sortilin vps10;
DE   AltName: Full=Vacuolar carboxypeptidase sorting receptor vps10;
DE   Flags: Precursor;
GN   Name=vps10; Synonyms=vpsT; ORFNames=AN8880;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=21226815; DOI=10.1111/j.1600-0854.2011.01164.x;
RA   Pantazopoulou A., Penalva M.A.;
RT   "Characterization of Aspergillus nidulans RabC(Rab6).";
RL   Traffic 12:386-406(2011).
CC   -!- FUNCTION: Functions as a sorting receptor in the Golgi compartment
CC       required for the intracellular sorting and delivery of soluble
CC       vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.
CC       Executes multiple rounds of sorting by cycling between the late
CC       Golgi and a prevacuolar endosome-like compartment (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network
CC       membrane {ECO:0000269|PubMed:21226815}; Multi-pass membrane
CC       protein {ECO:0000269|PubMed:21226815}. Prevacuolar compartment
CC       membrane {ECO:0000269|PubMed:21226815}; Multi-pass membrane
CC       protein {ECO:0000269|PubMed:21226815}. Note=Cycles between the
CC       Golgi apparatus and the prevacuolar compartment.
CC   -!- SIMILARITY: Belongs to the VPS10-related sortilin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA64094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AACD01000164; EAA64094.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001307; CBF84749.1; -; Genomic_DNA.
DR   RefSeq; XP_682149.1; XM_677057.1.
DR   ProteinModelPortal; Q5AS50; -.
DR   STRING; 162425.CADANIAP00007992; -.
DR   EnsemblFungi; CADANIAT00007992; CADANIAP00007992; CADANIAG00007992.
DR   EnsemblFungi; EAA64094; EAA64094; AN8880.2.
DR   GeneID; 2868185; -.
DR   KEGG; ani:AN8880.2; -.
DR   HOGENOM; HOG000169063; -.
DR   InParanoid; Q5AS50; -.
DR   OrthoDB; EOG092C0D5Y; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Partially assembled WGS sequence.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR011040; Sialidases.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 3.
DR   SMART; SM00602; VPS10; 2.
DR   SUPFAM; SSF50939; SSF50939; 2.
PE   3: Inferred from homology;
DR   PRODOM; Q5AS50.
DR   SWISS-2DPAGE; Q5AS50.
KW   Complete proteome; Glycoprotein; Golgi apparatus; Membrane;
KW   Protein transport; Receptor; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix; Transport.
FT   SIGNAL        1     23       {ECO:0000255}.
FT   CHAIN        24   1416       Vacuolar protein sorting/targeting
FT                                protein 10.
FT                                /FTId=PRO_0000407518.
FT   TOPO_DOM     24   1284       Lumenal. {ECO:0000255}.
FT   TRANSMEM   1285   1305       Helical. {ECO:0000255}.
FT   TOPO_DOM   1306   1333       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM   1334   1354       Helical. {ECO:0000255}.
FT   TOPO_DOM   1355   1416       Lumenal. {ECO:0000255}.
FT   REPEAT       62     71       BNR 1.
FT   REPEAT      374    384       BNR 2.
FT   REPEAT      436    446       BNR 3.
FT   REPEAT      478    487       BNR 4.
FT   REPEAT      714    724       BNR 5.
FT   REPEAT      808    818       BNR 6.
FT   REPEAT     1077   1083       BNR 7.
FT   REPEAT     1115   1124       BNR 8.
FT   CARBOHYD    583    583       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    938    938       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1372   1372       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   1416 AA;  158405 MW;  6F33D0B6F995C74C CRC64;
     MIPRWIQLVG CLLLALMLPP SAAKKDKPGI SFHKLHEKPY SMFYFEKSDT VLLNLEDGEV
     LRSFDAGENW EVIEDNGMKH GVTSIHQHPF DEDKAYALGD DGKHWITTDK AKTWKSFKVP
     DQAYFKSPQT GPLTFHGRDS SKVIFETRPC PSCAPRSYYT TDDFDTIEVL TESAVGCYWA
     VGNPQFAAGP NMPKGMEERT VCVVPGLKAS SRFAFRLVYS DDYFRSQGIE TKLQDGRPVS
     GVTSIAQVKS FIVAAVESQG TTERALYVTT DIEKWHRAEF GDHRLEQDAY TVLESSDYSL
     QVDVLTNPFS GMGVLFTSNS DGTYFTRNIE HTNRGPRGYV DFEKLAAIQG IVLVNTVRNP
     DDVEAGASKE VVSQISFDDG RTFQPLKSTD GQRIHLHSVN SDTNLGRVFS SPAPGLVMGV
     GNTGDYLGKR SDGHLYVSDD AGLTWRLALK GPHKYEFGDQ GAVLVAISEA PKVKKIEYSL
     DHGKEWKSVD LPHEVDGETS TLTTTPDSTS LKFILLGHSK GEPSVYAIDF EDLHERKCED
     EDFDNHWPAR LDEHGEPDCL MGQKQFFRRR KANADCFVAE AFNSSMSKFE PCKCTVEDFE
     CQSTRTEDGK DCVPPKSFTP PDGDCINPDD TTMIPSGWRL IPGDVCVRDD GVNLDKDVEI
     PCKDVNNRPK SKEITSTMKM FSSGLSAYRY LERQVSNLGE DETVLMLSRN QELFVSHDHG
     QTWQQELKGA SIMKIVPHPY NSDTAYILTD SEEVFYTINR GATFGSFRAK TLPDYENGPI
     LRFHPLKRDW LLWVGTECDS GSCHSNAYFS DDRGDSWKTI LRHAKKCEFE YKENRPDSLY
     LVFCEQYENE DDKKRLQLMS TTDERFSDWE TVEENLVEYA TRAEYIILAS HTDKDNALKA
     RVSVDGTTFA DLKFPPNVVP AQNLYTLVDA SEHAIFLNGT TYVLSLDAVN QNDWGYVDFE
     RMQALEGVII ANIVSNVDEL SDGAPKRLRT MITHNDGGEW TLLAPPTKDA NGKKFPCSVV
     EGKGTEDCAL HLHGYTERAD PRDTFSSGSA IGLMMGLGNV GDRLTSKDEA DTFLTMDGGI
     TWKSVKKGRY MWEYGDSGSV IVIVSEQKST KVLHYSTDEG ATWQDYYFSD EEIEVIDIST
     VPSDTSKKFI LWGKKSDELV TVNVDFSGLY DRDCEFDDKG GDVSDDYQLW TPKHPFQEEN
     SDYECDYNYE RQNDGTCKLV PGLKPHDPVG YCKAHPDAIE YFEPTGYRRI PQTTCQGGYN
     LDHQTAKPCP GKQQEYDKKH GISGIGLFFA IVAPIAVAGA VGYYIYTKWD GKFGQIRLGE
     TSTGTQGILS RDSLLVTVPI AIIAGIVAVA KALPLLVTSL WRSASGYMRV GNRSYPRPYA
     SRASFAARRG DYSSVVEDED ELLGVVDFDG DEEEDS
//

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