(data stored in ACNUC16935 zone)

SWISSPROT: LMBD1_EMENI

ID   LMBD1_EMENI             Reviewed;         575 AA.
AC   Q5BDG8; C8VM25;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   05-JUL-2017, entry version 55.
DE   RecName: Full=Probable lysosomal cobalamin transporter;
GN   ORFNames=AN1412;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Probable lysosomal cobalamin transporter. Required to
CC       export cobalamin from lysosomes allowing its conversion to
CC       cofactors (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LIMR family. LMBRD1 subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CBF84806.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=EAA64542.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AACD01000022; EAA64542.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001307; CBF84806.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_659016.1; XM_653924.1.
DR   EnsemblFungi; CADANIAT00008023; CADANIAP00008023; CADANIAG00008023.
DR   EnsemblFungi; EAA64542; EAA64542; AN1412.2.
DR   GeneID; 2875665; -.
DR   KEGG; ani:AN1412.2; -.
DR   HOGENOM; HOG000076791; -.
DR   InParanoid; Q5BDG8; -.
DR   KO; K14617; -.
DR   OrthoDB; EOG092C1PY7; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Partially assembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006876; LMBR1-like_membr_prot.
DR   Pfam; PF04791; LMBR1; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q5BDG8.
DR   SWISS-2DPAGE; Q5BDG8.
KW   Cobalamin; Cobalt; Complete proteome; Glycoprotein; Lysosome;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN         1    575       Probable lysosomal cobalamin transporter.
FT                                /FTId=PRO_0000365831.
FT   TRANSMEM      8     28       Helical. {ECO:0000255}.
FT   TRANSMEM     46     66       Helical. {ECO:0000255}.
FT   TRANSMEM     95    115       Helical. {ECO:0000255}.
FT   TRANSMEM    144    164       Helical. {ECO:0000255}.
FT   TRANSMEM    188    208       Helical. {ECO:0000255}.
FT   TRANSMEM    314    334       Helical. {ECO:0000255}.
FT   TRANSMEM    376    396       Helical. {ECO:0000255}.
FT   TRANSMEM    420    440       Helical. {ECO:0000255}.
FT   TRANSMEM    504    524       Helical. {ECO:0000255}.
FT   CARBOHYD    233    233       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   575 AA;  64190 MW;  5B93CF0AA71DADBC CRC64;
     MILLQTSLIW VVYAVVVVVL FAVASVFIYV YQSPRDRSPS VTLTCIVAIT SLLATILLLP
     VDVALVSSTV SSSVGQRKDW ATPEVVDRIT FSLTLVYYIL YSLDILLCLL VVPFVYFWYE
     EYDEVAAQTG EQSSGQRFWG ASKYTLSFIA ILIILFLVGV FVPISRANGG NGLDPFKSLL
     GENRGERALT FALGLLITIG MYVYALHTST GLAVLPIRLI KGGPRLSNAG SWNATFTVQL
     DSNRERRRQL EGRCGGNFDH LSSKDRRELD ALIREERTLI RRQRLAQEAD GKGNALLPRM
     WFRLEAFFRP FRRLVGLILL LLVLLIWVSM ILTASDKAKN SICKRHCGYV LGHINIFNPI
     NEIFVQSAKL FPIDYAIFTM LVLLLFFGTV VGIATVGIRF LWISIFRIRL GHTSPQALLV
     MTAILMLSIL ALNYSISMIV APQYATFGPQ TFCDRLSGSS VLPELQCVVK RCSEAFGSDA
     AKKVCTPSVA STVLNRVTVS FPFFGAIFFW SQFAFIGVYL LALITSLLRS PKLDEQQLDE
     DAEEAEEEAL LSGSRRNMDD RWQSIVGRAS RSEDT
//

If you have problems or comments...

PBIL Back to PBIL home page