(data stored in ACNUC16935 zone)

SWISSPROT: CSN8_EMENI

ID   CSN8_EMENI              Reviewed;         212 AA.
AC   P0C624; C8VMC3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   05-JUL-2017, entry version 43.
DE   RecName: Full=COP9 signalosome complex subunit 8;
DE            Short=CSN complex subunit 8;
GN   Name=csnH; Synonyms=csn8; ORFNames=AN10208;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   IDENTIFICATION IN THE CSN COMPLEX, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RX   PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA   Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K.,
RA   Draht O.W., Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT   "An eight-subunit COP9 signalosome with an intact JAMM motif is
RT   required for fungal fruit body formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that
CC       acts as an regulator of the ubiquitin (Ubl) conjugation pathway by
CC       mediating the deneddylation of the cullin subunit of SCF-type E3
CC       ubiquitin-protein ligase complexes (By similarity). The CSN
CC       complex seems to link protein degradation to sexual development.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:17470786}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN8 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AACD01000022; Type=Frameshift; Positions=136; Evidence={ECO:0000305};
DR   EMBL; AACD01000022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BN001307; CBF84891.1; -; Genomic_DNA.
DR   SMR; P0C624; -.
DR   DIP; DIP-60932N; -.
DR   STRING; 162425.CADANIAP00008069; -.
DR   EnsemblFungi; CADANIAT00008069; CADANIAP00008069; CADANIAG00008069.
DR   HOGENOM; HOG000157472; -.
DR   InParanoid; P0C624; -.
DR   OMA; DPSLQNC; -.
DR   OrthoDB; EOG092C4BM1; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Partially assembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR033464; CSN8_PSD8_EIF3K.
DR   Pfam; PF10075; CSN8_PSD8_EIF3K; 1.
PE   1: Evidence at protein level;
DR   PRODOM; P0C624.
DR   SWISS-2DPAGE; P0C624.
KW   Complete proteome; Cytoplasm; Nucleus; Reference proteome;
KW   Signalosome.
FT   CHAIN         1    212       COP9 signalosome complex subunit 8.
FT                                /FTId=PRO_0000314746.
FT   DOMAIN       84    166       PCI.
SQ   SEQUENCE   212 AA;  23913 MW;  627C3CC311FD93C1 CRC64;
     MDLPPLSLDQ LSAVITAGPT PTDLYTSLSA YEEQACLLSA TDPSEKDLLL EFYTAFFFSH
     LLTDQICEAR ALTRRIPREI SRLDAMQTCS LLLRAVWQSK HTEIYKILRE LPWPGRSQPL
     VQRYESYFQE KTLVEMSNSY ETIRIAAAAT YLGLDPAAVE GDIIEKFTAC GWKWDSEKQL
     LHPKPVVTAP PKDDSLQNEL SRVMALISNQ GS
//

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