(data stored in ACNUC16935 zone)

SWISSPROT: Q5BD54_EMENI

ID   Q5BD54_EMENI            Unreviewed;       266 AA.
AC   Q5BD54; C8VMR0;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   16-JAN-2019, entry version 71.
DE   RecName: Full=ER membrane protein complex subunit 3 {ECO:0000256|PIRNR:PIRNR010045};
GN   ORFNames=ANIA_01526 {ECO:0000313|EMBL:CBF85046.1};
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321 {ECO:0000313|EMBL:CBF85046.1, ECO:0000313|Proteomes:UP000000560};
RN   [1] {ECO:0000313|Proteomes:UP000000560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.J., Wortman J.R.,
RA   Batzoglou S., Lee S.I., Basturkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M., Hynes M., Paoletti M., Fischer R., Miller B., Dyer P.,
RA   Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2] {ECO:0000313|Proteomes:UP000000560}
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139
RC   {ECO:0000313|Proteomes:UP000000560};
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: The EMC seems to be required for efficient folding of
CC       proteins in the endoplasmic reticulum (ER).
CC       {ECO:0000256|PIRNR:PIRNR010045}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|PIRNR:PIRNR010045};
CC       Multi-pass membrane protein {ECO:0000256|PIRNR:PIRNR010045}.
CC   -!- SIMILARITY: Belongs to the EMC3 family.
CC       {ECO:0000256|PIRNR:PIRNR010045}.
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DR   EMBL; BN001307; CBF85046.1; -; Genomic_DNA.
DR   RefSeq; XP_659130.1; XM_654038.1.
DR   STRING; 162425.CADANIAP00008154; -.
DR   EnsemblFungi; CBF85046; CBF85046; ANIA_01526.
DR   EnsemblFungi; EAA63782; EAA63782; AN1526.2.
DR   GeneID; 2875242; -.
DR   KEGG; ani:AN1526.2; -.
DR   HOGENOM; HOG000158234; -.
DR   OMA; PNIRGWV; -.
DR   OrthoDB; 1482782at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   GO; GO:0072546; C:ER membrane protein complex; IBA:GO_Central.
DR   GO; GO:0034975; P:protein folding in endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR008568; EMC3.
DR   InterPro; IPR002809; EMC3/TMCO1.
DR   PANTHER; PTHR13116; PTHR13116; 1.
DR   Pfam; PF01956; EMC3_TMCO1; 1.
DR   PIRSF; PIRSF010045; DUF850_TM_euk; 1.
DR   SMART; SM01415; DUF106; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q5BD54.
DR   SWISS-2DPAGE; Q5BD54.
KW   Complete proteome {ECO:0000313|Proteomes:UP000000560};
KW   Membrane {ECO:0000256|PIRNR:PIRNR010045};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000560};
KW   Transmembrane {ECO:0000256|PIRNR:PIRNR010045};
KW   Transmembrane helix {ECO:0000256|PIRNR:PIRNR010045}.
FT   TRANSMEM     16     34       Helical. {ECO:0000256|PIRNR:PIRNR010045}.
FT   TRANSMEM    130    151       Helical. {ECO:0000256|PIRNR:PIRNR010045}.
FT   TRANSMEM    182    201       Helical. {ECO:0000256|PIRNR:PIRNR010045}.
SQ   SEQUENCE   266 AA;  29797 MW;  1478156A9B4CC733 CRC64;
     MALQGVEQTI LRDPALFYWI LIPISVVMIL TGMLRHYATI LMNSPPKPPA TLAESRERLS
     LFRAVNLRNH APAVLSKEAF EMRKNYLVTG FQTGAFLKDP NSRGQPPANP MSDPAAMEGM
     MGMMKGNMMM MIPQTLIMSW INAFFSGFVI LKLPFPLTIR FKSMLQSGVM TRDLDVRWVS
     SLSWYFLNLF GLQSVFGFIL GSDNAANHMA QQMGPMGPAA GANPFQPGQD PHKMYLNEAE
     NLEVFEHFSI LDGIEDRVLR KYGAAQ
//

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