(data stored in ACNUC16935 zone)

SWISSPROT: CSN4_EMENI

ID   CSN4_EMENI              Reviewed;         408 AA.
AC   Q9C467; C8VMX6; Q5BD41;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 2.
DT   05-JUL-2017, entry version 78.
DE   RecName: Full=COP9 signalosome complex subunit 4;
DE            Short=Signalosome subunit 4;
GN   Name=csnD; Synonyms=csn4; ORFNames=AN1539;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, IDENTIFICATION IN THE CSN
RP   COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=17470786; DOI=10.1073/pnas.0702108104;
RA   Busch S., Schwier E.U., Nahlik K., Bayram O., Helmstaedt K.,
RA   Draht O.W., Krappmann S., Valerius O., Lipscomb W.N., Braus G.H.;
RT   "An eight-subunit COP9 signalosome with an intact JAMM motif is
RT   required for fungal fruit body formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8089-8094(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Component of the COP9 signalosome (CSN) complex that
CC       acts as an regulator of the ubiquitin (Ubl) conjugation pathway by
CC       mediating the deneddylation of the cullin subunit of SCF-type E3
CC       ubiquitin-protein ligase complexes (By similarity). The CSN
CC       complex seems to link protein degradation to sexual development.
CC       Required for fruit body formation. {ECO:0000250,
CC       ECO:0000269|PubMed:17470786}.
CC   -!- SUBUNIT: Component of the COP9 signalosome (CSN) complex.
CC       {ECO:0000269|PubMed:17470786}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CSN4 family. {ECO:0000305}.
DR   EMBL; AF236662; AAK14055.2; -; Genomic_DNA.
DR   EMBL; AACD01000025; EAA64246.1; -; Genomic_DNA.
DR   EMBL; BN001307; CBF85069.1; -; Genomic_DNA.
DR   RefSeq; XP_659143.1; XM_654051.1.
DR   ProteinModelPortal; Q9C467; -.
DR   SMR; Q9C467; -.
DR   DIP; DIP-60928N; -.
DR   STRING; 162425.CADANIAP00008166; -.
DR   EnsemblFungi; CADANIAT00008166; CADANIAP00008166; CADANIAG00008166.
DR   EnsemblFungi; EAA64246; EAA64246; AN1539.2.
DR   GeneID; 2875265; -.
DR   KEGG; ani:AN1539.2; -.
DR   HOGENOM; HOG000158382; -.
DR   InParanoid; Q9C467; -.
DR   KO; K12178; -.
DR   OMA; YNNITFR; -.
DR   OrthoDB; EOG092C2ODF; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Partially assembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000338; P:protein deneddylation; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF01399; PCI; 1.
DR   SMART; SM00088; PINT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   1: Evidence at protein level;
DR   PRODOM; Q9C467.
DR   SWISS-2DPAGE; Q9C467.
KW   Complete proteome; Cytoplasm; Nucleus; Reference proteome;
KW   Signalosome.
FT   CHAIN         1    408       COP9 signalosome complex subunit 4.
FT                                /FTId=PRO_0000314744.
FT   DOMAIN      265    371       PCI.
SQ   SEQUENCE   408 AA;  44876 MW;  AB38FCBC6DE4ED99 CRC64;
     MPSQKIISAL AEIESSASPQ NKLQLYNDLL SETVSASPEP QLADDLIYYL DSVLSEDLSI
     VAARPILDSF IYTLRKLSSE TQIKVAQHAV NLLQSRSASV EEQDAQIREI LADAYEAEEE
     YIAAARALQG IHIDSSQRLV SDSAKVKLWI RIVRLYLEED DTTSAEAFLN RIKNLPSKIE
     DHELKLHFRL SQARIQDARR RFLDASQEYF AVSLAAGVDE SDRLQALAAA IRCAVLAPAG
     PQRSRTLATL YKDDRATSVE EFGILEKMFL DRLLTPEEVS AFAQRLAPHQ LAQTADGTTV
     LDKAVVEHNL VAASKLYENI KTDALGAILG LQASGDLTAG EKAEAYAARM VEQGRLSGSI
     DQIDGIIYFE SNTTATGRHI RQWDAGVQGL SEGVERVATN IAEGHLVR
//

If you have problems or comments...

PBIL Back to PBIL home page