(data stored in ACNUC1104 zone)

SWISSPROT: D3UYU1_XENBS

ID   D3UYU1_XENBS            Unreviewed;       647 AA.
AC   D3UYU1;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 60.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS01158470};
GN   Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN   ECO:0000313|EMBL:CBJ79469.1};
GN   OrderedLocusNames=XBJ1_0319 {ECO:0000313|EMBL:CBJ79469.1};
OS   Xenorhabdus bovienii (strain SS-2004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406818 {ECO:0000313|EMBL:CBJ79469.1, ECO:0000313|Proteomes:UP000002045};
RN   [1] {ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|Proteomes:UP000002045};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ79469.1, ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|EMBL:CBJ79469.1,
RC   ECO:0000313|Proteomes:UP000002045};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in
CC       DNA. It is required for dam-dependent methyl-directed DNA mismatch
CC       repair. May act as a "molecular matchmaker", a protein that
CC       promotes the formation of a stable complex between two or more
CC       DNA-binding proteins in an ATP-dependent manner without itself
CC       being part of a final effector complex. {ECO:0000256|HAMAP-
CC       Rule:MF_00149, ECO:0000256|SAAS:SAAS01158472}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|HAMAP-Rule:MF_00149, ECO:0000256|SAAS:SAAS01076587}.
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DR   EMBL; FN667741; CBJ79469.1; -; Genomic_DNA.
DR   RefSeq; WP_012986929.1; NC_013892.1.
DR   STRING; 406818.XBJ1_0319; -.
DR   EnsemblBacteria; CBJ79469; CBJ79469; XBJ1_0319.
DR   GeneID; 8829944; -.
DR   KEGG; xbo:XBJ1_0319; -.
DR   PATRIC; fig|406818.4.peg.290; -.
DR   eggNOG; ENOG4105DC6; Bacteria.
DR   eggNOG; COG0323; LUCA.
DR   HOGENOM; HOG000256551; -.
DR   KO; K03572; -.
DR   OMA; ISWQHGD; -.
DR   BioCyc; XBOV406818:XBJ1_RS01385-MONOMER; -.
DR   Proteomes; UP000002045; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATPase activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd00075; HATPase_c; 1.
DR   Gene3D; 2.30.42.20; -; 1.
DR   Gene3D; 3.30.1370.100; -; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR002099; DNA_mismatch_repair_N.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR038973; MutL/Mlh/Pms.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   PANTHER; PTHR10073; PTHR10073; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF118116; SSF118116; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   TIGRFAMs; TIGR00585; mutl; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3UYU1.
DR   SWISS-2DPAGE; D3UYU1.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002045};
KW   DNA damage {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00440831};
KW   DNA repair {ECO:0000256|HAMAP-Rule:MF_00149,
KW   ECO:0000256|SAAS:SAAS00020747};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002045}.
FT   DOMAIN      212    330       DNA_mis_repair. {ECO:0000259|SMART:
FT                                SM01340}.
FT   DOMAIN      470    605       MutL_C. {ECO:0000259|SMART:SM00853}.
SQ   SEQUENCE   647 AA;  71348 MW;  3A55207F181C007A CRC64;
     MAIRILPPQL ANQIAAGEVV ERPASVVKEL VENSLDAGAT RIDIEIERGG AKLIRIRDNG
     CGIDQQDLTL ALARHATSKI ASLDDLEAIV SMGFRGEALA SISSVSRLTL TSRTESQTEA
     WQAYAEGRDM EVTVKPAAHP VGTTVEVLDL FYNTPARRKF LRTEKTEFGH LDEVVRRIAL
     ARLDVAINLH HNGKLVRQYR PAKEESQHER RLAAICGMAF VQQALALSWQ HDSLSIKGWV
     ADPMSDTVGG DIQYCYVNGR MMRDRLINHA IRQAYQDLLQ GEKQPAYVLY LEIDPHQVDV
     NVHPAKHEVR FHQARLVHDF IYQGVAAVLK QRGKGAELAL GCEEPAASWV PENRLSAGEN
     HFLQQNTASL KASPPSRAAA APSVSSGGHD KEQPQLDRPH SGNDTRQLHH GENYQKKQGE
     LYQKMMQSAP EEKRPLFPER AVSVREKAAP IPVGAALLQG KNISYSFGKV LSIHAASYAL
     IESPLGIGLL SLPVAERWLK QVQLTPGELG LKSQPLLIPL KLSLSQAEID ALKQNSELLK
     TFGIESTVAH GKVTIHAVSL PLRQQNLPKL LPELLNYLVE QPSACAEQVA IWLSRHVGSE
     HETWNIAQAV QLLADVERLC PQLVESPPEG LLQLIDLQAV VALLNHE
//

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