(data stored in ACNUC1104 zone)

SWISSPROT: D3UZ35_XENBS

ID   D3UZ35_XENBS            Unreviewed;       304 AA.
AC   D3UZ35;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   RecName: Full=Ribonuclease BN {ECO:0000256|HAMAP-Rule:MF_01818};
DE            Short=RNase BN {ECO:0000256|HAMAP-Rule:MF_01818};
DE            EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_01818};
DE   AltName: Full=Ribonuclease Z homolog {ECO:0000256|HAMAP-Rule:MF_01818};
DE            Short=RNase Z homolog {ECO:0000256|HAMAP-Rule:MF_01818};
GN   Name=elaC {ECO:0000313|EMBL:CBJ79563.1};
GN   Synonyms=rbn {ECO:0000256|HAMAP-Rule:MF_01818};
GN   OrderedLocusNames=XBJ1_0413 {ECO:0000313|EMBL:CBJ79563.1};
OS   Xenorhabdus bovienii (strain SS-2004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406818 {ECO:0000313|EMBL:CBJ79563.1, ECO:0000313|Proteomes:UP000002045};
RN   [1] {ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|Proteomes:UP000002045};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ79563.1, ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|EMBL:CBJ79563.1,
RC   ECO:0000313|Proteomes:UP000002045};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: Zinc phosphodiesterase, which has both exoribonuclease
CC       and endoribonuclease activities. {ECO:0000256|HAMAP-
CC       Rule:MF_01818}.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_01818};
CC       Note=Binds 2 Zn(2+) ions. {ECO:0000256|HAMAP-Rule:MF_01818};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01818}.
CC   -!- SIMILARITY: Belongs to the RNase Z family. RNase BN subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01818}.
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DR   EMBL; FN667741; CBJ79563.1; -; Genomic_DNA.
DR   RefSeq; WP_012987020.1; NC_013892.1.
DR   STRING; 406818.XBJ1_0413; -.
DR   EnsemblBacteria; CBJ79563; CBJ79563; XBJ1_0413.
DR   GeneID; 8830037; -.
DR   KEGG; xbo:XBJ1_0413; -.
DR   PATRIC; fig|406818.4.peg.382; -.
DR   eggNOG; ENOG4105IES; Bacteria.
DR   eggNOG; COG1234; LUCA.
DR   HOGENOM; HOG000272419; -.
DR   KO; K00784; -.
DR   OMA; GTQRQMM; -.
DR   BioCyc; XBOV406818:XBJ1_RS01830-MONOMER; -.
DR   Proteomes; UP000002045; Chromosome.
DR   GO; GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042779; P:tRNA 3'-trailer cleavage; IEA:InterPro.
DR   CDD; cd07717; RNaseZ_ZiPD-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   HAMAP; MF_01818; RNase_Z_BN; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR013471; RNase_Z/BN.
DR   Pfam; PF12706; Lactamase_B_2; 2.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   TIGRFAMs; TIGR02651; RNase_Z; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3UZ35.
DR   SWISS-2DPAGE; D3UZ35.
KW   Complete proteome {ECO:0000313|Proteomes:UP000002045};
KW   Endonuclease {ECO:0000256|HAMAP-Rule:MF_01818};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_01818};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01818};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_01818};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_01818};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002045};
KW   tRNA processing {ECO:0000256|HAMAP-Rule:MF_01818};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_01818}.
FT   DOMAIN       36    153       Lactamase_B. {ECO:0000259|Pfam:PF12706}.
FT   DOMAIN      195    270       Lactamase_B. {ECO:0000259|Pfam:PF12706}.
FT   ACT_SITE     67     67       Proton acceptor. {ECO:0000256|HAMAP-Rule:
FT                                MF_01818}.
FT   METAL        63     63       Zinc 1; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
FT   METAL        65     65       Zinc 1; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
FT   METAL        67     67       Zinc 2; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
FT   METAL        68     68       Zinc 2; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
FT   METAL       140    140       Zinc 1; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
FT   METAL       211    211       Zinc 1; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
FT   METAL       211    211       Zinc 2; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
FT   METAL       269    269       Zinc 2; catalytic. {ECO:0000256|HAMAP-
FT                                Rule:MF_01818}.
SQ   SEQUENCE   304 AA;  33312 MW;  F8D2F5789CD48982 CRC64;
     MELKFLGTSA GVPTKERNVT SLVLDLRGIR NALWMFDCGE GTQHQILNSS IKIPKLEKIF
     ITHLHGDHIF GLPGLLCSRS MGGSTDPVTL YGPKGIRQFV ETTLQLSGSF LTYPLDIVEV
     QSGLLFDDGE LKVTAYALNH RVECYGYRIE EHDKPGGLNT QRLNQDNIPR GSWMQTLKQG
     GTVTLEDGRT VCGKDYLGAP ISGKSLAIFG DTTPTPEALK LAANVDVMVH EITLEDALAE
     KANNNGHSTT KQAATLARDA KAKHFIATHI SGRYGIEDCP RLLAECREIF PNTDLAEDFA
     IFIV
//

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