(data stored in ACNUC1104 zone)

SWISSPROT: D3UZ63_XENBS

ID   D3UZ63_XENBS            Unreviewed;       527 AA.
AC   D3UZ63;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 52.
DE   SubName: Full=Putative sodium:hydrogen antiporter (CPA1 family) {ECO:0000313|EMBL:CBJ79645.1};
GN   Name=yjcE {ECO:0000313|EMBL:CBJ79645.1};
GN   OrderedLocusNames=XBJ1_0496 {ECO:0000313|EMBL:CBJ79645.1};
OS   Xenorhabdus bovienii (strain SS-2004).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406818 {ECO:0000313|EMBL:CBJ79645.1, ECO:0000313|Proteomes:UP000002045};
RN   [1] {ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|Proteomes:UP000002045};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ79645.1, ECO:0000313|Proteomes:UP000002045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SS-2004 {ECO:0000313|EMBL:CBJ79645.1,
RC   ECO:0000313|Proteomes:UP000002045};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange
CC       for external protons. {ECO:0000256|RuleBase:RU366002}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU366002}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU366002}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1
CC       (CPA1) transporter (TC 2.A.36) family.
CC       {ECO:0000256|RuleBase:RU366002}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU366002}.
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DR   EMBL; FN667741; CBJ79645.1; -; Genomic_DNA.
DR   STRING; 406818.XBJ1_0496; -.
DR   EnsemblBacteria; CBJ79645; CBJ79645; XBJ1_0496.
DR   KEGG; xbo:XBJ1_0496; -.
DR   eggNOG; ENOG4105EEQ; Bacteria.
DR   eggNOG; COG0025; LUCA.
DR   HOGENOM; HOG000263347; -.
DR   KO; K03316; -.
DR   OMA; RFCLMFF; -.
DR   Proteomes; UP000002045; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004705; Cation/H_exchanger_CPA1_bac.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR10110; PTHR10110; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   TIGRFAMs; TIGR00831; a_cpa1; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3UZ63.
DR   SWISS-2DPAGE; D3UZ63.
KW   Antiport {ECO:0000256|RuleBase:RU366002};
KW   Cell inner membrane {ECO:0000256|RuleBase:RU366002};
KW   Cell membrane {ECO:0000256|RuleBase:RU366002};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002045};
KW   Ion transport {ECO:0000256|RuleBase:RU366002};
KW   Membrane {ECO:0000256|RuleBase:RU366002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002045};
KW   Sodium {ECO:0000256|RuleBase:RU366002};
KW   Sodium transport {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane {ECO:0000256|RuleBase:RU366002};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU366002};
KW   Transport {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM      7     28       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     63     86       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM     92    114       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    135    157       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    163    181       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    219    240       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    292    315       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    336    363       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   TRANSMEM    375    398       Helical. {ECO:0000256|RuleBase:RU366002}.
FT   DOMAIN        4    399       Na_H_Exchanger. {ECO:0000259|Pfam:
FT                                PF00999}.
SQ   SEQUENCE   527 AA;  57997 MW;  1D9D87F3E49239BC CRC64;
     MIPFRIPLPI VQIAMGALLA WPHFGLHVTF DPELFLVLLI PPLLFVDGWK TPTREFFQHG
     REIVILVLFL VLVTVVGIGY LIYWLLPGIP LIAAFALAAV LSPTDAVALS SIVGKGRIPK
     NMMSVLEGEA LMNDASGLVA LKFAVAIAMG TMVFTVTGAT IEFFKVAIGG LLSGIAITWL
     YSKSLRLMSR WSGDDPATQI MFMMLLPFAS YMIAEHIGVS GILAAVAAGM TISKSGVIRN
     APLAMRLRAD NVWGMLAFVF NGLVFVMLGL QLPGIWETSV EQAELDPQVE TWMLFAAVGI
     IYVALVLLRF CWLWLMKNAS KVLMKKKPLE FASYTMRELC LASLAGVRGA ITLAGALSVP
     LFLPDGDPFP ARYQLIFIAA GVILFSLFVG VVVLPLLLRG MKVGDKQADI NEIRMAKAAM
     AEVAIVSMNK MEERLSASTE EKLDAEVVSE IASRVTGYLR RRTVGKDEIE HNLLVEELER
     RFRLTALRAE RGELYHLRAT RKISNETLQT LLHDLDLLEA LLVVKDQ
//

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