SWISSPROT: D3VH28_XENNA

ID   D3VH28_XENNA            Unreviewed;       105 AA.
AC   D3VH28;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 56.
DE   RecName: Full=Met repressor {ECO:0000256|HAMAP-Rule:MF_00744, ECO:0000256|SAAS:SAAS00343455};
DE   AltName: Full=Met regulon regulatory protein MetJ {ECO:0000256|HAMAP-Rule:MF_00744};
GN   Name=metJ {ECO:0000256|HAMAP-Rule:MF_00744,
GN   ECO:0000313|EMBL:CBJ88313.1};
GN   OrderedLocusNames=XNC1_0225 {ECO:0000313|EMBL:CBJ88313.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88313.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88313.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: This regulatory protein, when combined with SAM (S-
CC       adenosylmethionine) represses the expression of the methionine
CC       regulon and of enzymes involved in SAM synthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00744, ECO:0000256|SAAS:SAAS00343434}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00744,
CC       ECO:0000256|SAAS:SAAS00343435}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00744,
CC       ECO:0000256|SAAS:SAAS00012459}.
CC   -!- DOMAIN: Does not bind DNA by a helix-turn-helix motif.
CC       {ECO:0000256|HAMAP-Rule:MF_00744}.
CC   -!- SIMILARITY: Belongs to the MetJ family. {ECO:0000256|HAMAP-
CC       Rule:MF_00744, ECO:0000256|SAAS:SAAS00539576}.
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DR   EMBL; FN667742; CBJ88313.1; -; Genomic_DNA.
DR   RefSeq; WP_010847675.1; NC_014228.1.
DR   STRING; 406817.XNC1_0225; -.
DR   EnsemblBacteria; CBJ88313; CBJ88313; XNC1_0225.
DR   KEGG; xne:XNC1_0225; -.
DR   eggNOG; ENOG4105GGQ; Bacteria.
DR   eggNOG; COG3060; LUCA.
DR   HOGENOM; HOG000271582; -.
DR   KO; K03764; -.
DR   OMA; KWNGEYI; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd00490; Met_repressor_MetJ; 1.
DR   Gene3D; 1.10.140.10; -; 1.
DR   HAMAP; MF_00744; MetJ; 1.
DR   InterPro; IPR002084; Met_repressor_MetJ.
DR   InterPro; IPR023453; Met_repressor_MetJ_dom_sf.
DR   InterPro; IPR010985; Ribbon_hlx_hlx.
DR   Pfam; PF01340; MetJ; 1.
DR   ProDom; PD020365; Met_repressor_MetJ; 1.
DR   SUPFAM; SSF47598; SSF47598; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3VH28.
DR   SWISS-2DPAGE; D3VH28.
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00744,
KW   ECO:0000256|SAAS:SAAS00422005};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00744,
KW   ECO:0000256|SAAS:SAAS00012454};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00744,
KW   ECO:0000256|SAAS:SAAS00422008};
KW   Methionine biosynthesis {ECO:0000256|HAMAP-Rule:MF_00744,
KW   ECO:0000256|SAAS:SAAS00106923};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075};
KW   Repressor {ECO:0000256|HAMAP-Rule:MF_00744,
KW   ECO:0000256|SAAS:SAAS00422009};
KW   Transcription {ECO:0000256|HAMAP-Rule:MF_00744,
KW   ECO:0000256|SAAS:SAAS00422006};
KW   Transcription regulation {ECO:0000256|HAMAP-Rule:MF_00744,
KW   ECO:0000256|SAAS:SAAS00422010}.
SQ   SEQUENCE   105 AA;  12203 MW;  818D42A8320EDE0F CRC64;
     MAEWNGEYVS PYAEHGKKSE QVKKITVSIP LKVLKILTDE RTRRQVNNLR HATNSELLCE
     AFLHAFTGQP LPNDNDLRKE RHDEIPEAAK VMMRELGIDP DTWEY
//