(data stored in ACNUC1104 zone)

SWISSPROT: D3VHW6_XENNA

ID   D3VHW6_XENNA            Unreviewed;       676 AA.
AC   D3VHW6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 61.
DE   RecName: Full=ATP-dependent DNA helicase Rep {ECO:0000256|HAMAP-Rule:MF_01920};
DE            EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01920};
GN   Name=rep {ECO:0000256|HAMAP-Rule:MF_01920,
GN   ECO:0000313|EMBL:CBJ88455.1};
GN   OrderedLocusNames=XNC1_0378 {ECO:0000313|EMBL:CBJ88455.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88455.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88455.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: Rep helicase is a single-stranded DNA-dependent ATPase
CC       involved in DNA replication; it can initiate unwinding at a nick
CC       in the DNA. It binds to the single-stranded DNA and acts in a
CC       progressive fashion along the DNA in the 3' to 5' direction.
CC       {ECO:0000256|HAMAP-Rule:MF_01920}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01920,
CC         ECO:0000256|SAAS:SAAS01129065};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01920}.
CC   -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC       {ECO:0000256|HAMAP-Rule:MF_01920, ECO:0000256|SAAS:SAAS00709641}.
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DR   EMBL; FN667742; CBJ88455.1; -; Genomic_DNA.
DR   RefSeq; WP_010845331.1; NC_014228.1.
DR   STRING; 406817.XNC1_0378; -.
DR   EnsemblBacteria; CBJ88455; CBJ88455; XNC1_0378.
DR   KEGG; xne:XNC1_0378; -.
DR   eggNOG; ENOG4105C4R; Bacteria.
DR   eggNOG; COG0210; LUCA.
DR   HOGENOM; HOG000033015; -.
DR   KO; K03656; -.
DR   OMA; HCANILI; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004003; F:ATP-dependent DNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.160; -; 1.
DR   HAMAP; MF_01920; Helicase_Rep; 1.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR005752; Helicase_Rep.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR034739; UvrD/AddA_N.
DR   PANTHER; PTHR11070; PTHR11070; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR01074; rep; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3VHW6.
DR   SWISS-2DPAGE; D3VHW6.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_01920,
KW   ECO:0000256|SAAS:SAAS00146071}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_01920};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_01920,
KW   ECO:0000256|SAAS:SAAS00745286};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_01920,
KW   ECO:0000256|SAAS:SAAS00553650, ECO:0000313|EMBL:CBJ88455.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_01920,
KW   ECO:0000256|SAAS:SAAS00146062, ECO:0000313|EMBL:CBJ88455.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01920,
KW   ECO:0000256|SAAS:SAAS00145996};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075}.
FT   DOMAIN        1    280       UvrD-like helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51198}.
FT   DOMAIN      281    562       UvrD-like helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51217}.
FT   COILED      646    666       {ECO:0000256|SAM:Coils}.
FT   BINDING     278    278       ATP. {ECO:0000256|HAMAP-Rule:MF_01920}.
SQ   SEQUENCE   676 AA;  78283 MW;  2086BEB1F6CBF6A8 CRC64;
     MRLNPSQQQA VEFVTGPCLV LAGAGSGKTR VITNKIAHLI RACGYQARHI AAVTFTNKAA
     REMKERVAQT LGRKETKGLM ISTFHTLGLE IIKREYQALG MKSNFSLFDD QDQMALLKDL
     TADLLEEDKD LLQKLISSIS NWKNDLMSPE QVVRSARSAQ EHQFAECYRR YDLHLNSCNI
     LDFDDLITKP TLLLMRDENV RERWQNRIRY LLVDEYQDTN TSQYQLVKLL VGNRARFTVV
     GDDDQSIYSW RGARPQNLIL LKEDFPQLNV IKLEQNYRSS GRILKAANIL IANNPHVFEK
     KLFSELHYGD PLRVLEANNE DHEAERVIGE LIAHHFINKT EYKDYAILYR GNHQSRIFEK
     MLMQNRIPYR ISGGTSFFSR PEIKDLLSYL RVLTNPEDDS AFLRIVNTPR REIGAVTIQK
     LGEWANQRNK SLYQASFDLG LEQHLTGRGL AALHRFTHWM EEISRQVERE PLLAVRDLLR
     GMDYESWLYE TSPSPKAAEM RMKNVNQLFT WMSEMLEGDD LNEPMTLSQV VARFTLRDML
     ERGEEDDALD QVQLMTLHAS KGLEFPYVFL VGMEEGLLPH QSSIDEENIE EERRLAYVGI
     TRAQRVLFFT LSKERRQYGE LIRPEPSRFL LELPQDDLDW PRGKRVVSAE ERMKQGQSRL
     ADIKSRLGLG QKNVGK
//

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