(data stored in ACNUC1104 zone)

SWISSPROT: D3VHW8_XENNA

ID   D3VHW8_XENNA            Unreviewed;       427 AA.
AC   D3VHW8;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   08-MAY-2019, entry version 62.
DE   RecName: Full=ATP-dependent RNA helicase RhlB {ECO:0000256|HAMAP-Rule:MF_00661, ECO:0000256|SAAS:SAAS01081517};
DE            EC=3.6.4.13 {ECO:0000256|HAMAP-Rule:MF_00661, ECO:0000256|SAAS:SAAS01081507};
GN   Name=rhlB {ECO:0000256|HAMAP-Rule:MF_00661,
GN   ECO:0000313|EMBL:CBJ88457.1};
GN   OrderedLocusNames=XNC1_0380 {ECO:0000313|EMBL:CBJ88457.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88457.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88457.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: DEAD-box RNA helicase involved in RNA degradation. Has
CC       RNA-dependent ATPase activity and unwinds double-stranded RNA.
CC       {ECO:0000256|HAMAP-Rule:MF_00661, ECO:0000256|SAAS:SAAS01081506}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00661,
CC         ECO:0000256|SAAS:SAAS01118058};
CC   -!- SUBUNIT: Component of the RNA degradosome, which is a multiprotein
CC       complex involved in RNA processing and mRNA degradation.
CC       {ECO:0000256|HAMAP-Rule:MF_00661, ECO:0000256|SAAS:SAAS01081515}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00661,
CC       ECO:0000256|SAAS:SAAS01081519}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. RhlB
CC       subfamily. {ECO:0000256|HAMAP-Rule:MF_00661,
CC       ECO:0000256|SAAS:SAAS01081508}.
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DR   EMBL; FN667742; CBJ88457.1; -; Genomic_DNA.
DR   RefSeq; WP_010845329.1; NC_014228.1.
DR   STRING; 406817.XNC1_0380; -.
DR   EnsemblBacteria; CBJ88457; CBJ88457; XNC1_0380.
DR   KEGG; xne:XNC1_0380; -.
DR   eggNOG; ENOG4105C1J; Bacteria.
DR   eggNOG; COG0513; LUCA.
DR   HOGENOM; HOG000268807; -.
DR   KO; K03732; -.
DR   OMA; RNPIRIL; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004004; F:ATP-dependent RNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006401; P:RNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd00079; HELICc; 1.
DR   HAMAP; MF_00661; DEAD_helicase_RhlB; 1.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR023554; RNA_helicase_ATP-dep_RhlB.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3VHW8.
DR   SWISS-2DPAGE; D3VHW8.
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00661,
KW   ECO:0000256|RuleBase:RU000492, ECO:0000256|SAAS:SAAS01081512};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00661,
KW   ECO:0000256|SAAS:SAAS01081510};
KW   Helicase {ECO:0000256|HAMAP-Rule:MF_00661,
KW   ECO:0000256|RuleBase:RU000492, ECO:0000256|SAAS:SAAS01081509,
KW   ECO:0000313|EMBL:CBJ88457.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00661,
KW   ECO:0000256|RuleBase:RU000492, ECO:0000256|SAAS:SAAS01081514,
KW   ECO:0000313|EMBL:CBJ88457.1};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00661,
KW   ECO:0000256|RuleBase:RU000492, ECO:0000256|SAAS:SAAS01081511};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075};
KW   RNA-binding {ECO:0000256|HAMAP-Rule:MF_00661,
KW   ECO:0000256|SAAS:SAAS01081518}.
FT   DOMAIN        9     37       Q_MOTIF. {ECO:0000259|PROSITE:PS51195}.
FT   DOMAIN       40    219       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      245    390       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   MOTIF         9     37       Q motif. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00552}.
SQ   SEQUENCE   427 AA;  48272 MW;  73BA42179FFC02F6 CRC64;
     MSKTHLTEKK FSDFALHPKV LGALDKKGFS NCTPIQALTL PFTVEGRDVA GQAQTGTGKT
     LAFLASTFHY LLTHPAGKER KINQPRALIM APTRELAVQI YSDAKELAEV TGLKMGLAYG
     GDGYDKQLKV LESGVDIVIG TTGRLIDYAK QGHIHLGAIQ VVVLDEADRM YDLGFIKDIR
     WLFRRIPAAT ERLNLLFSAT LSYRVRELAF EQMNNPEYVE VEPLQKTGHR IREELFYPSN
     EEKMRLLQTL LEEEWPDRCI IFANTKHRCE DIWTHLAADG HRVGLLTGDV AQKKRLRILE
     EFSLGNLDIL VATDVAARGL HIPSVTHVFN YDLPDDCEDY VHRIGRTGRA GESGHSISLA
     CEEYVLNLPS IEEYIQHQIP VSKYNSDALL KDLPVPKRRN RTRPGGHPRR INMPRRGNPT
     RNRKHPS
//

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