(data stored in ACNUC1104 zone)

SWISSPROT: D3VHY4_XENNA

ID   D3VHY4_XENNA            Unreviewed;       245 AA.
AC   D3VHY4;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   16-JAN-2019, entry version 56.
DE   RecName: Full=UDP-N-acetyl-D-mannosaminuronic acid transferase {ECO:0000256|HAMAP-Rule:MF_01001, ECO:0000256|SAAS:SAAS00727171};
DE            Short=UDP-ManNAcA transferase {ECO:0000256|HAMAP-Rule:MF_01001};
DE            EC=2.4.1.180 {ECO:0000256|HAMAP-Rule:MF_01001, ECO:0000256|SAAS:SAAS00727172};
GN   Name=rffM {ECO:0000256|HAMAP-Rule:MF_01001,
GN   ECO:0000313|EMBL:CBJ88473.1};
GN   Synonyms=wecG {ECO:0000256|HAMAP-Rule:MF_01001};
GN   OrderedLocusNames=XNC1_0396 {ECO:0000313|EMBL:CBJ88473.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88473.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88473.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- FUNCTION: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid
CC       II), the second lipid-linked intermediate involved in
CC       enterobacterial common antigen (ECA) synthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_01001, ECO:0000256|SAAS:SAAS00727166}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-acetyl-alpha-D-glucosaminyl-1-diphospho-di-trans,octa-
CC         cis-undecaprenol + UDP-N-acetyl-alpha-D-mannosaminouronate =
CC         beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-1-diphospho-di-trans,octa-
CC         cis-undecaprenol + H(+) + UDP; Xref=Rhea:RHEA:28366,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61495,
CC         ChEBI:CHEBI:62959, ChEBI:CHEBI:70731; EC=2.4.1.180;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_01001,
CC         ECO:0000256|SAAS:SAAS01118203};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial
CC       common antigen biosynthesis. {ECO:0000256|HAMAP-Rule:MF_01001,
CC       ECO:0000256|SAAS:SAAS00727167}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 26 family.
CC       {ECO:0000256|HAMAP-Rule:MF_01001, ECO:0000256|SAAS:SAAS00768719}.
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DR   EMBL; FN667742; CBJ88473.1; -; Genomic_DNA.
DR   RefSeq; WP_010845314.1; NC_014228.1.
DR   STRING; 406817.XNC1_0396; -.
DR   CAZy; GT26; Glycosyltransferase Family 26.
DR   EnsemblBacteria; CBJ88473; CBJ88473; XNC1_0396.
DR   KEGG; xne:XNC1_0396; -.
DR   eggNOG; ENOG4108UHC; Bacteria.
DR   eggNOG; COG1922; LUCA.
DR   HOGENOM; HOG000075380; -.
DR   KO; K02852; -.
DR   OMA; PWRWRRM; -.
DR   UniPathway; UPA00566; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0047241; F:lipopolysaccharide N-acetylmannosaminouronosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06533; Glyco_transf_WecG_TagA; 1.
DR   HAMAP; MF_01001; WecG_RffM; 1.
DR   InterPro; IPR023085; UDP-ManNAcA_Trfase_WecG.
DR   InterPro; IPR004629; WecB_TagA_CpsF.
DR   PANTHER; PTHR34136; PTHR34136; 1.
DR   Pfam; PF03808; Glyco_tran_WecB; 1.
DR   TIGRFAMs; TIGR00696; wecG_tagA_cpsF; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3VHY4.
DR   SWISS-2DPAGE; D3VHY4.
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   Glycosyltransferase {ECO:0000256|HAMAP-Rule:MF_01001,
KW   ECO:0000256|SAAS:SAAS00768725, ECO:0000313|EMBL:CBJ88473.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075};
KW   Transferase {ECO:0000256|HAMAP-Rule:MF_01001,
KW   ECO:0000256|SAAS:SAAS00768714, ECO:0000313|EMBL:CBJ88473.1}.
SQ   SEQUENCE   245 AA;  27776 MW;  12DCF2C682A9C3D3 CRC64;
     MGLNNIPKYR IRGLNIWGFR GMSHFLDHLF QGGRVQTGTL VAINAEKVLT AEQDNALNML
     LNEAEYLYAD GISIVRAIRR KYPDADVSRI AGADLWEALM ERAGREGTPV FLVGGKPAIL
     VQTENKLRTQ WNVNIVGSQD GYFTPETRDA VFERIRASGA AIITVAMGSP KQEIFMRDCR
     KVYPDALYMG IGGTYDVFTG HIKRAPKVWQ NLGLEWLYRL LSQPSRIRRQ IKLLRFLGYY
     YSGKL
//

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