(data stored in ACNUC1104 zone)

SWISSPROT: D3VHZ4_XENNA

ID   D3VHZ4_XENNA            Unreviewed;       840 AA.
AC   D3VHZ4;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   20-APR-2010, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   RecName: Full=Adenylate cyclase {ECO:0000256|RuleBase:RU000604};
DE            EC=4.6.1.1 {ECO:0000256|RuleBase:RU000604};
GN   Name=cyaA {ECO:0000313|EMBL:CBJ88483.1};
GN   OrderedLocusNames=XNC1_0406 {ECO:0000313|EMBL:CBJ88483.1};
OS   Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 /
OS   NCIB 9965 / AN6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Xenorhabdus.
OX   NCBI_TaxID=406817 {ECO:0000313|EMBL:CBJ88483.1, ECO:0000313|Proteomes:UP000008075};
RN   [1] {ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RA   Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S.,
RA   Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P.,
RA   Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S.,
RA   Suen G.;
RT   "Complete genome sequence of Xenorhabdus nematophila (strain ATCC
RT   19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6).";
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CBJ88483.1, ECO:0000313|Proteomes:UP000008075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6
RC   {ECO:0000313|Proteomes:UP000008075};
RX   PubMed=22125637; DOI=10.1371/journal.pone.0027909;
RA   Chaston J.M., Suen G., Tucker S.L., Andersen A.W., Bhasin A., Bode E.,
RA   Bode H.B., Brachmann A.O., Cowles C.E., Cowles K.N., Darby C.,
RA   de Leon L., Drace K., Du Z., Givaudan A., Herbert Tran E.E.,
RA   Jewell K.A., Knack J.J., Krasomil-Osterfeld K.C., Kukor R., Lanois A.,
RA   Latreille P., Leimgruber N.K., Lipke C.M., Liu R., Lu X.,
RA   Martens E.C., Marri P.R., Medigue C., Menard M.L., Miller N.M.,
RA   Morales-Soto N., Norton S., Ogier J.C., Orchard S.S., Park D.,
RA   Park Y., Qurollo B.A., Sugar D.R., Richards G.R., Rouy Z.,
RA   Slominski B., Slominski K., Snyder H., Tjaden B.C., van der Hoeven R.,
RA   Welch R.D., Wheeler C., Xiang B., Barbazuk B., Gaudriault S.,
RA   Goodner B., Slater S.C., Forst S., Goldman B.S., Goodrich-Blair H.;
RT   "The entomopathogenic bacterial endosymbionts xenorhabdus and
RT   photorhabdus: convergent lifestyles from divergent genomes.";
RL   PLoS ONE 6:e27909-e27909(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP = 3',5'-cyclic AMP + diphosphate;
CC         Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58165; EC=4.6.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000604};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU000604}.
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-1 family.
CC       {ECO:0000256|RuleBase:RU004184}.
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DR   EMBL; FN667742; CBJ88483.1; -; Genomic_DNA.
DR   STRING; 406817.XNC1_0406; -.
DR   EnsemblBacteria; CBJ88483; CBJ88483; XNC1_0406.
DR   KEGG; xne:XNC1_0406; -.
DR   eggNOG; ENOG4107T0K; Bacteria.
DR   eggNOG; COG3072; LUCA.
DR   HOGENOM; HOG000270910; -.
DR   KO; K05851; -.
DR   OMA; HPLLPGY; -.
DR   Proteomes; UP000008075; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000274; Adenylate_cyclase_1.
DR   InterPro; IPR024686; Adenylate_cyclase_1_CS.
DR   InterPro; IPR024685; Adenylate_cyclase_1_N.
DR   PANTHER; PTHR38760; PTHR38760; 1.
DR   Pfam; PF12633; Adenyl_cycl_N; 1.
DR   Pfam; PF01295; Adenylate_cycl; 1.
DR   PIRSF; PIRSF001444; Adenylate_cycl; 1.
DR   PROSITE; PS01092; ADENYLATE_CYCLASE_1_1; 1.
DR   PROSITE; PS01093; ADENYLATE_CYCLASE_1_2; 1.
PE   3: Inferred from homology;
DR   PRODOM; D3VHZ4.
DR   SWISS-2DPAGE; D3VHZ4.
KW   cAMP biosynthesis {ECO:0000256|RuleBase:RU000604};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008075};
KW   Lyase {ECO:0000256|RuleBase:RU000604, ECO:0000313|EMBL:CBJ88483.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008075}.
FT   DOMAIN        1    174       Adenyl_cycl_N. {ECO:0000259|Pfam:
FT                                PF12633}.
SQ   SEQUENCE   840 AA;  96181 MW;  D7EDD0CBE367E9B8 CRC64;
     MSAAFKQVYS LIPVLLHHHH PMMPGYIKNN TPHGVCFFAP DESQQFWIND LEGRLSGVLP
     YAPNGELPIT GIYSMGSTSS IGQSCSSDID IWVCHQSWLD NGEKALLEQK CTLIGQWAAS
     LGIEATFFLI DENRFRHNAS GSLNGEDCGS TQHILLLDEF YRTAVCMAGK RLLWTMVPVE
     EEAHYDEYVL SLYAQGVLTP NEWLDLGGLG QLSAEEYFGA SLWQLYKSVD SPYKAVLKSL
     LLEAYSWEYP NGKLLAMEMK QHLHDGAIVS FGLDAYSMML ERVTRYLTAT NDLTRLDLAR
     RCFYLKVCEK WSASHHDAGC TGWRRQVISQ LVNEWGWDDS KLTMLNNRNA WKIEQVREAH
     NELLDTMMQS YRNLIRFARR NHLSVSASPQ DIGVLTRKLY AAFEALPGKV TLVNPQISPD
     LSEQDLTFIY VPPGRVNRSG WYLYNHTPTI EAIIGHQPLE YNRYLNKLVS WTYFNGLLTK
     ETRIHIHNGN SPCNKHKLCD LVNDIATHFP IRLPAPTPKA LYSPCEIRHL AIIVNLEQDP
     TVEFSNRVIH FDFRNMNVFS FGESQQCLVG SIDLLYRNSW NEVRTLHFSG EQSVLEALKT
     ILGKMHRDAA PPAGVEVFCY SRHLRGLICT RIQQLVSECI ELRLSSNRQD PNRFKALRIS
     GQTWGLFFER LNVSVQKLEN AVEFYGAISN TKLHGLPVKI DTKEKHLPPV IDGFACEGII
     QFFFENIEKN QGFNIYILDE SNRVEIYSHC EGSKEELVRD ISRFYSSSHD RFTYGSSFIN
     FNLPQFYQII QKGERTHVVP FVDGTFPSDD MEANETRLNI DSCLEEACRP HDPYRSLYHY
//

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